About: Pathogen inactivation and removal procedures used in the production of intravenous immunoglobulins

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pathogen inactivation and removal procedures used in the production of intravenous immunoglobulins
Creator	Boschetti, Nicola Kempf, Christoph Stucki, Martin
Source	Elsevier; Medline; PMC
abstract	Abstract Patients with immunodeficiencies or some types of autoimmune diseases rely on a safe therapy with intravenous immunoglobulins (IVIGs) manufactured from human plasma, the only available source for this therapeutic. Since plasma is predisposed to contamination by a variety of blood-borne pathogens, ascertaining and ensuring the pathogen safety of plasma-derived therapeutics is a priority among manufacturers. State-of-the-art manufacturing processes provide a high safety standard by incorporating virus elimination procedures into the manufacturing process. Based on their mechanism these procedures are grouped into three classes: partitioning, inactivation, and virusfiltration.
has issue date	2007-03-31(xsd:dateTime)
bibo:doi	10.1016/j.biologicals.2006.01.002
bibo:pmid	16581263
has license	els-covid
sha1sum (hex)	e6a90fe14fd8cbe84ebf7a1d52342c5ae6490d9b
schema:url	https://doi.org/10.1016/j.biologicals.2006.01.002
resource representing a document's title	Pathogen inactivation and removal procedures used in the production of intravenous immunoglobulins
has PubMed Central identifier	PMC7129354
has PubMed identifier	16581263
schema:publication	Biologicals
resource representing a document's body	covid:e6a90fe14fd8cbe84ebf7a1d52342c5ae6490d9b#body_text
is schema:about of	named entity 'Since' named entity 'predisposed' named entity 'contamination' named entity 'Patients' named entity 'PATHOGEN' named entity 'THERAPEUTICS' named entity 'TYPES' named entity 'PARTITIONING' named entity 'PRIORITY' named entity 'MANUFACTURING PROCESSES' named entity 'REMOVAL PROCEDURES' named entity 'CONTAMINATION' named entity 'CLASSES' named entity 'GROUPED' named entity 'MANUFACTURED' named entity 'INACTIVATION' named entity 'SAFE' named entity 'SOURCE' named entity 'PREDISPOSED' named entity 'SAFETY STANDARD' named entity 'THESE' named entity 'HIGH' named entity 'AUTOIMMUNE DISEASES' named entity 'PROCEDURES' named entity 'MANUFACTURING PROCESS' named entity 'VARIETY' named entity 'BASED' named entity 'THERAPY' named entity 'IMMUNODEFICIENCIES' named entity 'USED' named entity 'PRODUCTION' named entity 'INACTIVATION' named entity 'THERAPEUTIC' named entity 'PATHOGEN' named entity 'ART' named entity 'BLOOD-BORNE PATHOGENS' named entity 'THEIR' named entity 'AVAILABLE' named entity 'SAFETY' named entity 'PROVIDE' named entity 'MECHANISM' named entity 'DERIVED' named entity 'PLASMA' named entity 'INTRAVENOUS IMMUNOGLOBULINS' named entity 'HUMAN PLASMA' named entity 'IS A' named entity 'INTRAVENOUS IMMUNOGLOBULINS' named entity 'PATIENTS' named entity 'safety standard' named entity 'therapy' named entity 'incorporating' named entity 'therapeutic' named entity 'therapeutics' named entity 'plasma' named entity 'processes' named entity 'intravenous immunoglobulins' named entity 'plasma' named entity 'autoimmune diseases' named entity 'TSE' named entity 'brain function' named entity 'IVIG' named entity 'antibodies' named entity 'hepatitis C virus' named entity 'polio virus' named entity 'immunomodulatory' named entity 'HAV' named entity 'IVIG' named entity 'detergents' named entity 'Human pathogens' named entity 'Parvovirus B19' named entity 'infection' named entity 'plasma' named entity 'pepsin' named entity 'viruses' named entity 'infectivity' named entity 'albumin' named entity 'sorbitol' named entity 'viruses' named entity 'insoluble'

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