About: Serum Proteomic Fingerprints of Adult Patients with Severe Acute Respiratory Syndrome

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Serum Proteomic Fingerprints of Adult Patients with Severe Acute Respiratory Syndrome
Creator	Lee, Nelson Sung, Joseph Chan, K Chim, Stephen Chiu, Rossa Lo, Y Ngai, Sai Pang, Ronald Poon, Terence Tong, Yu-Kwan Wong, Ronald
Source	Medline; PMC
abstract	Background: Severe acute respiratory syndrome (SARS) is an emerging infectious disease caused by a new coronavirus strain, SARS-CoV. Specific proteomic patterns might be present in serum in response to the infection and could be useful for early detection of the disease. Methods: Using surface-enhanced laser desorption/ionization (SELDI) ProteinChip technology, we profiled and compared serum proteins of 39 patients with early-stage SARS infection and 39 non-SARS patients who were suspected cases during the SARS outbreak period. Proteomic patterns associated with SARS were identified by bioinformatic and biostatistical analyses. Features of interest were then purified and identified by tandem mass spectrometry. Results: Twenty proteomic features were significantly different between the 2 groups. Fifteen were increased in the SARS group, and 5 were decreased. Their concentrations were correlated with 2 or more clinical and/or biochemical variables. Two were correlated with the SARS-CoV viral load. Hierarchical clustering analysis showed that a majority of the SARS patients (95%) had similar serum proteomic profiles and identified 2 subgroups with poor prognosis. ROC curve analysis identified individual features as potential biomarkers for SARS diagnosis (areas under ROC curves, 0.733–0.995). ROC curve areas were largest for an N-terminal fragment of complement C3c α chain (m/z 28 119) and an internal fragment of fibrinogen α-E chain (m/z 5908). Immunoglobulin κ light chain (m/z 24 505) positively correlated with viral load. Conclusions: Specific proteomic fingerprints in the sera of adult SARS patients could be used to identify SARS cases early during onset with high specificity and sensitivity.
has issue date	2006-03-01(xsd:dateTime)
bibo:doi	10.1373/clinchem.2005.061689
bibo:pmid	16423906
has license	no-cc
sha1sum (hex)	29db5c5ee576aa04ff7807287ee91b2ca42a5cff
schema:url	https://doi.org/10.1373/clinchem.2005.061689
resource representing a document's title	Serum Proteomic Fingerprints of Adult Patients with Severe Acute Respiratory Syndrome
has PubMed Central identifier	PMC7108167
has PubMed identifier	16423906
schema:publication	Clin Chem
resource representing a document's body	covid:29db5c5ee576aa04ff7807287ee91b2ca42a5cff#body_text
is schema:about of	named entity 'SERUM' named entity 'ASSOCIATED WITH' named entity 'METHODS' named entity 'SUBGROUPS' named entity '2 OR MORE' named entity 'COMPLEMENT C3C' named entity 'BIOMARKERS' named entity 'SIMILAR' named entity 'POOR PROGNOSIS' named entity 'THEIR' named entity 'PATTERNS' named entity 'ROC CURVE' named entity 'DECREASED' named entity 'SARS-COV' named entity 'INCREASED' named entity 'FRAGMENT OF' named entity 'RESULTS' named entity 'LARGEST' named entity 'POTENTIAL' named entity 'PURIFIED' named entity 'identified' named entity 'analysis' named entity 'profiled' named entity 'SARS DIAGNOSIS' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' covid:arg/29db5c5ee576aa04ff7807287ee91b2ca42a5cff named entity 'LASER DESORPTION' named entity 'FIBRINOGEN' named entity 'ENHANCED' named entity 'ADULT' named entity 'FINGERPRINTS' named entity 'PATIENTS' named entity 'PERIOD' named entity 'INFECTION' named entity 'SERUM PROTEINS' named entity 'OUTBREAK' named entity 'HIERARCHICAL CLUSTERING' named entity 'NON-' named entity 'INTERNAL' named entity 'CLUSTERING ANALYSIS' named entity 'SARS' named entity 'CHAIN' named entity 'IDENTIFIED BY' named entity 'DIFFERENT' named entity 'BIOINFORMATIC' named entity 'PATIENTS' named entity '0.995' named entity 'FIFTEEN' named entity 'SURFACE' named entity 'MAJORITY' named entity 'FEATURES' named entity 'N-TERMINAL FRAGMENT' named entity 'USING' named entity 'ANALYSIS' named entity 'VARIABLES' named entity 'TWENTY' named entity 'PROTEOMIC' named entity 'GROUP' named entity 'PROTEINCHIP' named entity '5908' named entity 'BIOCHEMICAL' named entity 'A3 CHAIN' named entity 'PROTEOMIC' named entity 'GROUPS' named entity 'CLINICAL' named entity 'ROC' named entity 'TANDEM MASS SPECTROMETRY' named entity 'IDENTIFIED' named entity 'OF INTEREST' named entity 'SERUM' named entity 'CONCENTRATIONS'

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