About: Abstract Objective To investigate the characteristics and predictive roles of lymphocyte subsets in COVID-19 patients. Method We evaluated lymphocyte subsets and other clinical features of COVID-19 patients and analysed their potential impacts on COVID-19 outcomes. Results 1. Lymphocyte subset counts in the peripheral blood of patients with COVID-19 were significantly reduced, especially in patients with severe disease. 2. In patients with non-severe diseases, the time from symptom onset to hospital admission was positively correlated with total T cell counts. 3. Among COVID-19 patients who did not reach the composite endpoint, lymphocyte subset counts were higher than in patients who had reached the composite endpoint. 4. The Kaplan-Meier survival curves showed significant differences in COVID-19 patients, classified by the levels of total, CD8+ and CD4+ T cells at admission. Conclusion Our study shows that the total, CD8+ and CD4+ T cell counts in patients with COVID-19 were significantly reduced, especially in patients with severe disease. T lymphocyte subsets were significantly associated with a higher occurrence of composite endpoint events. These subsets may help identify patients with a high risk of composite endpoint events.   Goto Sponge  NotDistinct  Permalink

An Entity of Type : fabio:Abstract, within Data Space : covidontheweb.inria.fr associated with source document(s)

AttributesValues
type
value
  • Abstract Objective To investigate the characteristics and predictive roles of lymphocyte subsets in COVID-19 patients. Method We evaluated lymphocyte subsets and other clinical features of COVID-19 patients and analysed their potential impacts on COVID-19 outcomes. Results 1. Lymphocyte subset counts in the peripheral blood of patients with COVID-19 were significantly reduced, especially in patients with severe disease. 2. In patients with non-severe diseases, the time from symptom onset to hospital admission was positively correlated with total T cell counts. 3. Among COVID-19 patients who did not reach the composite endpoint, lymphocyte subset counts were higher than in patients who had reached the composite endpoint. 4. The Kaplan-Meier survival curves showed significant differences in COVID-19 patients, classified by the levels of total, CD8+ and CD4+ T cells at admission. Conclusion Our study shows that the total, CD8+ and CD4+ T cell counts in patients with COVID-19 were significantly reduced, especially in patients with severe disease. T lymphocyte subsets were significantly associated with a higher occurrence of composite endpoint events. These subsets may help identify patients with a high risk of composite endpoint events.
Subject
  • Zoonoses
  • Immune system
  • Lymphocytes
  • Viral respiratory tract infections
  • COVID-19
  • Lymph fluid
  • Lymphatic system
  • Lymphatic tissue
  • Occupational safety and health
part of
is abstract of
is hasSource of
Faceted Search & Find service v1.13.91 as of Mar 24 2020


Alternative Linked Data Documents: Sponger | ODE     Content Formats:       RDF       ODATA       Microdata      About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data]
OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software