About: The characteristics and predictive role of lymphocyte subsets in COVID-19 patients

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The characteristics and predictive role of lymphocyte subsets in COVID-19 patients
Creator	Chen, Li Yang, Ming Li, Lei Li, Xiang Jiang, Lin Li, Zhang Zhang, Wenjing Hospital, Jinyintan Jin, Ting Liu, Jihai Wang, Hongxiang Wuhan, China\| Zhou, Fangfang
Source	Elsevier; Medline; PMC
abstract	Abstract Objective To investigate the characteristics and predictive roles of lymphocyte subsets in COVID-19 patients. Method We evaluated lymphocyte subsets and other clinical features of COVID-19 patients and analysed their potential impacts on COVID-19 outcomes. Results 1. Lymphocyte subset counts in the peripheral blood of patients with COVID-19 were significantly reduced, especially in patients with severe disease. 2. In patients with non-severe diseases, the time from symptom onset to hospital admission was positively correlated with total T cell counts. 3. Among COVID-19 patients who did not reach the composite endpoint, lymphocyte subset counts were higher than in patients who had reached the composite endpoint. 4. The Kaplan-Meier survival curves showed significant differences in COVID-19 patients, classified by the levels of total, CD8+ and CD4+ T cells at admission. Conclusion Our study shows that the total, CD8+ and CD4+ T cell counts in patients with COVID-19 were significantly reduced, especially in patients with severe disease. T lymphocyte subsets were significantly associated with a higher occurrence of composite endpoint events. These subsets may help identify patients with a high risk of composite endpoint events.
has issue date	2020-08-03(xsd:dateTime)
bibo:doi	10.1016/j.ijid.2020.06.079
bibo:pmid	32758688
has license	els-covid
sha1sum (hex)	27354d67b83f0afc481f819699fe7282deb404fe
schema:url	https://doi.org/10.1016/j.ijid.2020.06.079
resource representing a document's title	The characteristics and predictive role of lymphocyte subsets in COVID-19 patients
has PubMed Central identifier	PMC7398035
has PubMed identifier	32758688
schema:publication	Int J Infect Dis
resource representing a document's body	covid:27354d67b83f0afc481f819699fe7282deb404fe#body_text
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