About: SIC1

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An Entity of Type : yago:Sequence108459252, within Data Space : covidontheweb.inria.fr associated with source document(s)

Sic1, a protein, is a stoichiometric inhibitor of Cdk1-Clb (B-type cyclins) complexes in the budding yeast Saccharomyces cerevisiae. Because B-type cyclin-Cdk1 complexes are the drivers of S-phase initiation, Sic1 prevents premature S-phase entry. Multisite phosphorylation of Sic1 is thought to time Sic1 ubiquitination and destruction, and by extension, the timing of S-phase entry.

Attributes	Values
type	Thing polymer biomolecule entity matter biopolymer protein yago:Abstraction100002137 yago:Group100031264 yago:PhysicalEntity100001930 yago:Part113809207 yago:Relation100031921 chemical compound organic compound yago:WikicatSaccharomycesCerevisiaeGenes chemical substance Biomolecule chemical substance drug protein Inhibitor yago:Chemical114806838 yago:Compound114818238 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Protein114728724 yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatProteins yago:Arrangement107938773 yago:Ordering108456993 yago:Series108457976 yago:Gene105436752 yago:Sequence108459252
label	Sic1
comment	Sic1, a protein, is a stoichiometric inhibitor of Cdk1-Clb (B-type cyclins) complexes in the budding yeast Saccharomyces cerevisiae. Because B-type cyclin-Cdk1 complexes are the drivers of S-phase initiation, Sic1 prevents premature S-phase entry. Multisite phosphorylation of Sic1 is thought to time Sic1 ubiquitination and destruction, and by extension, the timing of S-phase entry.
sameAs	SIC1 SIC1 SIC1 SIC1 SIC1
name	Sic1
name	Sic1
topic	Ubiquitin ligase dbr:Clb_5,6_(Cdk1) Protein structure CDKN1B Cyclin-dependent kinase 1 dbr:Cell_division_control_protein_4 dbr:Cln3 dbr:Cdc14 dbr:Biochemical_switches_in_the_cell_cycle dbr:CDC34 Fuzzy complex dbr:Mitotic_exit dbr:Start_point_(yeast) dbr:Ultrasensitivity wikipedia-en:Sic1 dbr:Sic1#this
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described by	https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/class/yago/Compound114818238 https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/class/yago/WikicatProteins https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/class/yago/Arrangement107938773 https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/class/yago/Chemical114806838 https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/class/yago/Protein114728724 proxy:entity/http/dbpedia.org/resource/Protein https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/class/yago/Ordering108456993 https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/resource/Category:Proteins https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/class/yago/Part113809207 https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/resource/SWI/SNF https://covidontheweb.inria.fr:4443/about/id/entity/http/dbpedia.org/class/yago/OrganicCompound114727670
Subject	Proteins Cell cycle Saccharomyces cerevisiae genes
dbo:wikiPageID	19658010(xsd:integer)
dbo:wikiPageRevisionID	1003701946(xsd:integer)
dbo:wikiPageWikiLink	Adenocarcinoma SWI/SNF dbr:Metaphase C-terminus Cell cycle checkpoint Phosphorylation Transcription factor Stomach cancer Cyclin dbr:Tumor_suppressor_gene dbr:Clb_5,6_(Cdk1) Cell nucleus Chromosome segregation protein S phase Saccharomyces cerevisiae Budding Threonine

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