About: Nisoxetine

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An Entity of Type : yago:Quintessence114847103, within Data Space : covidontheweb.inria.fr associated with source document(s)

Nisoxetine, originally synthesized in the Lilly research laboratories during the early 1970s, is a potent and selective inhibitor for the reuptake of norepinephrine (noradrenaline) into synapses. It currently has no clinical applications in humans, although it was originally researched as an antidepressant. Nisoxetine is now widely used in scientific research as a standard selective norepinephrine reuptake inhibitor. It has been used to research obesity and energy balance, and exerts some local analgesia effects.

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label	Nisoxetine Nisoxetin 니속세틴
comment	Nisoxetin (LY-94939) ist ein Selektiver Noradrenalin-Wiederaufnahmehemmer (NARI). Ursprünglich wurde es als Antidepressivum entwickelt, kam aber nicht über die Entwicklungsstufe hinaus. Es gilt allerdings in der wissenschaftlichen Forschung als „Standard-NARI“ und wird als solches häufig verwendet. Es wird als Racemat eingesetzt. 니속세틴(Nisoxetine, LY-94939)은 노르에피네프린의 재흡수를 억제하는 약이다. 이성질체와 함께 라세믹 혼합물이다. 최근에는 니속세틴을 사람에게 투여하지 않으나, NRI 원래 우울증 치료제로서 연구와 현재 NRL 선별 기준으로서의 과학 연구에 널리 사용된다. Nisoxetine, originally synthesized in the Lilly research laboratories during the early 1970s, is a potent and selective inhibitor for the reuptake of norepinephrine (noradrenaline) into synapses. It currently has no clinical applications in humans, although it was originally researched as an antidepressant. Nisoxetine is now widely used in scientific research as a standard selective norepinephrine reuptake inhibitor. It has been used to research obesity and energy balance, and exerts some local analgesia effects.
differentFrom	dbr:Ansoxetine
sameAs	Nisoxetine Nisoxetine Nisoxetine Nisoxetine Nisoxetine Nisoxetine Nisoxetine Nisoxetine Nisoxetine
topic	dbr:Pharmacology_of_antidepressants dbr:Serotonin–norepinephrine–dopamine_reuptake_inhibitor Monoamine transporter dbr:PPPA_(drug) dbr:Synephrine dbr:N-Methyl-PPPA dbr:RTI-113 dbr:RTI-177 dbr:RTI-31 dbr:RTI-51 dbr:Monoamine_reuptake_inhibitor dbr:Norepinephrine_reuptake_inhibitor dbr:C17H21NO2 dbr:David_T._Wong dbr:List_of_adrenergic_drugs dbr:List_of_drugs:_Ni dbr:PCP_site_2 wikipedia-en:Nisoxetine dbr:Nisoxetine#this
depiction
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dbp:kegg	D05173
dbp:legalStatus	Never marketed
Subject	dbc:Catechol_ethers Amines Antidepressants Norepinephrine reuptake inhibitors
dbo:wikiPageID	16454909(xsd:integer)
dbo:wikiPageRevisionID	1107676221(xsd:integer)
dbo:wikiPageWikiLink	Diphenhydramine Anticholinergic dbr:Pro-opiomelanocortin Dissociation constant In vitro Obesity Serotonin Synapse Isomer Isotopic labeling Hypothalamus Racemic mixture Blood test Lidocaine Norepinephrine Catecholamine Neuropeptide Y Fluoxetine Local anesthetic dbr:Eli_Lilly_and_Company Selective serotonin reuptake inhibitor

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