An endothelin receptor antagonist (ERA) is a drug that blocks endothelin receptors. Three main kinds of ERAs exist:
* selective ETA receptor antagonists (sitaxentan, ambrisentan, atrasentan, BQ-123, zibotentan, ), which affect endothelin A receptors.
* dual antagonists (bosentan, macitentan, tezosentan), which affect both endothelin A and B receptors.
* selective ETB receptor antagonists (BQ-788 and A192621) which affect endothelin B receptors are used in research but have not yet reached the clinical trial stage.
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| - Endothelin receptor antagonist
- Antagonis reseptor endotel
- Antagonisti del recettore per le endoteline
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| - Gli antagonisti del recettore delle endoteline (abbreviati ERA, dall'inglese endothelin receptor antagonist) sono una classe di farmaci che bloccano il recettore delle endoteline.
- An endothelin receptor antagonist (ERA) is a drug that blocks endothelin receptors. Three main kinds of ERAs exist:
* selective ETA receptor antagonists (sitaxentan, ambrisentan, atrasentan, BQ-123, zibotentan, ), which affect endothelin A receptors.
* dual antagonists (bosentan, macitentan, tezosentan), which affect both endothelin A and B receptors.
* selective ETB receptor antagonists (BQ-788 and A192621) which affect endothelin B receptors are used in research but have not yet reached the clinical trial stage.
- Antagonis reseptor endotel (juga disebut endothelin receptor antagonist atau disingkat ERA) adalah golongan obat yang memblokir . ERA merupakan jenis obat yang digunakan untuk mengobati orang dengan hipertensi paru. Jenis obat dalam golongan ini adalah ambrisentan, bosentan, dan macitentan.
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| http://purl.org/li...ics/gold/hypernym
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| dbo:abstract
| - Gli antagonisti del recettore delle endoteline (abbreviati ERA, dall'inglese endothelin receptor antagonist) sono una classe di farmaci che bloccano il recettore delle endoteline.
- Antagonis reseptor endotel (juga disebut endothelin receptor antagonist atau disingkat ERA) adalah golongan obat yang memblokir . ERA merupakan jenis obat yang digunakan untuk mengobati orang dengan hipertensi paru. Jenis obat dalam golongan ini adalah ambrisentan, bosentan, dan macitentan.
- An endothelin receptor antagonist (ERA) is a drug that blocks endothelin receptors. Three main kinds of ERAs exist:
* selective ETA receptor antagonists (sitaxentan, ambrisentan, atrasentan, BQ-123, zibotentan, ), which affect endothelin A receptors.
* dual antagonists (bosentan, macitentan, tezosentan), which affect both endothelin A and B receptors.
* selective ETB receptor antagonists (BQ-788 and A192621) which affect endothelin B receptors are used in research but have not yet reached the clinical trial stage. Sitaxentan, ambrisentan and bosentan are mainly used for the treatment of pulmonary arterial hypertension, while atrasentan is an experimental anti-cancer drug.
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