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Diacylglycerol kinase (DGK or DAGK) is a family of enzymes that catalyzes the conversion of diacylglycerol (DAG) to phosphatidic acid (PA), utilizing ATP as a source of the phosphate. In non-stimulated cells, DGK activity is low, allowing DAG to be used for glycerophospholipid biosynthesis, but on receptor activation of the phosphoinositide pathway, DGK activity increases, driving the conversion of DAG to PA. As both lipids are thought to function as bioactive lipid signaling molecules with distinct cellular targets, DGK therefore occupies an important position, effectively serving as a switch by terminating the signalling of one lipid while simultaneously activating signalling by another.

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type
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  • Diacylglycerol kinase
  • Diacilglicerol cinasa
  • Diacylglycérol kinase
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  • La diacylglycérol kinase (DAGK ou DGK) est une famille de transférases qui catalysent la conversion de diglycérides (diacylglycérols, ou DAG) en acides phosphatidiques (PA) en utilisant l'ATP comme source de phosphate. Dans les cellules non activées par la voie métabolique de l'inositol phosphate, cette enzyme est faiblement active, de sorte que les diglycérides peuvent être utilisés pour former des phosphoglycérides, tandis qu'elle est sensiblement plus active dans les cellules activées, ce qui conduit à la formation d'acides phosphatidiques au lieu de phosphoglycérides.
  • Diacylglycerol kinase (DGK or DAGK) is a family of enzymes that catalyzes the conversion of diacylglycerol (DAG) to phosphatidic acid (PA), utilizing ATP as a source of the phosphate. In non-stimulated cells, DGK activity is low, allowing DAG to be used for glycerophospholipid biosynthesis, but on receptor activation of the phosphoinositide pathway, DGK activity increases, driving the conversion of DAG to PA. As both lipids are thought to function as bioactive lipid signaling molecules with distinct cellular targets, DGK therefore occupies an important position, effectively serving as a switch by terminating the signalling of one lipid while simultaneously activating signalling by another.
  • La diacilglicerol cinasa (DGK) (número EC 2.7.1.107) es una familia de enzimas que cataliza la conversión de diacilglicerol (DAG) a ácido fosfatídico (PA) utilizando ATP como fuente de fosfato.​ 1,2-diacilglicerol + ATP 1,2-diacilglicerol-3-fosfato + ADP
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  • Diacylglycerol kinase
name
  • Diacylglycerol kinase
  • Diacylglycerol kinase accessory domain
  • Diacylglycerol kinase catalytic domain
  • Prokaryotic diacylglycerol kinase
topic
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  • External Image
described by
dbp:pfamClan
  • CL0240
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