About: Scalable and Resilient SARS-CoV2 testing in an Academic Centre

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Scalable and Resilient SARS-CoV2 testing in an Academic Centre
Creator	Olsen, J Aitken, J Barrell, S Cherepanov, Cubitt, Dm, Snell Gandhi, S Goldman, J Goldstone, R Greco, M Howell, Kassiotis, G Ma, Turner Macrae, Nicod, J O'reilly N, Or, Song Pa, Walker Pollitt, M Pr, Grant Ratcliffe, P Reis E Sousa, Rosenthal, R Swanton, Wk, Wong Wt, Lu
topic	covid:95028e5c4d6620f082caf248e824f2428a2d5247#this
source	MedRxiv
abstract	The emergence of the novel coronavirus SARS-CoV-2 has led to a pandemic infecting more than two million people worldwide in less than four months, posing a major threat to healthcare systems. This is compounded by the shortage of available tests causing numerous healthcare workers to unnecessarily self-isolate. We provide a roadmap instructing how a research institute can be repurposed in the midst of this crisis, in collaboration with partner hospitals and an established diagnostic laboratory, harnessing existing expertise in virus handling, robotics, PCR, and data science to derive a rapid, high throughput diagnostic testing pipeline for detecting SARS-CoV-2 in patients with suspected COVID-19. The pipeline is used to detect SARS-CoV-2 from combined nose-throat swabs and endotracheal secretions/ bronchoalveolar lavage fluid. Notably, it relies on a series of in-house buffers for virus inactivation and the extraction of viral RNA, thereby reducing the dependency on commercial suppliers at times of global shortage. We use a commercial RT-PCR assay, from BGI, and results are reported with a bespoke online web application that integrates with the healthcare digital system. This strategy facilitates the remote reporting of thousands of samples a day with a turnaround time of under 24 hours, universally applicable to laboratories worldwide.
has issue date	2020-04-24(xsd:dateTime)
bibo:doi	10.1101/2020.04.19.20071373
has license	medrxiv
sha1sum (hex)	95028e5c4d6620f082caf248e824f2428a2d5247
schema:url	https://doi.org/10.1101/2020.04.19.20071373
resource representing a document's title	Scalable and Resilient SARS-CoV2 testing in an Academic Centre
resource representing a document's body	covid:95028e5c4d6620f082caf248e824f2428a2d5247#body_text
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