About: The effect of positive end-expiratory pressure on cardiac output and oxygen delivery during cardiopulmonary resuscitation

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About: The effect of positive end-expiratory pressure on cardiac output and oxygen delivery during cardiopulmonary resuscitation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The effect of positive end-expiratory pressure on cardiac output and oxygen delivery during cardiopulmonary resuscitation
Creator	Hossain, Jobayer Burr, Katlyn Hesek, Anne Keith, James Levenbrown, Yosef Shaffer, Thomas
Source	PMC
abstract	BACKGROUND: Positive end-expiratory pressure (PEEP) is used to optimize oxygenation by preventing alveolar collapse. However, PEEP can potentially decrease cardiac output through cardiopulmonary interactions. The effect of PEEP on cardiac output during cardiopulmonary resuscitation (CPR) is not known. METHODS: This was a preclinical randomized, controlled, animal study conducted in an animal research facility on 25 Landrace-Yorkshire pigs. After inducing cardiac arrest, CPR was performed with LUCAS 3. During CPR, pigs were ventilated at a PEEP of 0, 5, 10, 15, 20 cmH(2)O (randomly determined via lottery) for 9 min. Cardiac output, obtained via ultrasound dilution, and PaO(2) were measured, and oxygen delivery calculated for each PEEP. RESULTS: A mixed-effects repeated-measures analysis of variance was used to compare the baseline value adjusted mean cardiac output, PaO(2), and oxygen delivery between PEEP groups. Least significant difference test was used to conduct pairwise comparisons between PEEP groups. To determine optimum PEEP, Gaussian mixture model was applied to the adjusted means of cardiac output and oxygen delivery. Increasing PEEP to 10 and higher resulted in significant declines in cardiac output. A PEEP of 15 and higher resulted in significant declines in oxygen delivery. As PEEP was increased from 0 to 20, PaO(2) increased significantly. Gaussian mixture model identified the 0–5 PEEP group as providing optimal cardiac output and oxygen delivery, with PEEP of 5 providing the highest oxygen delivery. CONCLUSIONS: A PEEP of 0–5 resulted in the optimal oxygen delivery and cardiac output during CPR, with PEEP of 5 resulting in higher oxygen delivery, and a slightly lower, statistically insignificant cardiac output than PEEP of 0.
has issue date	2020-07-25(xsd:dateTime)
bibo:doi	10.1186/s40635-020-00330-2
has license	cc-by
sha1sum (hex)	8fe4ff1ed3d6017f4c892b7e2248489dec378e1d
schema:url	https://doi.org/10.1186/s40635-020-00330-2
resource representing a document's title	The effect of positive end-expiratory pressure on cardiac output and oxygen delivery during cardiopulmonary resuscitation
has PubMed Central identifier	PMC7382317
schema:publication	Intensive Care Med Exp
resource representing a document's body	covid:8fe4ff1ed3d6017f4c892b7e2248489dec378e1d#body_text
is schema:about of	named entity 'higher' named entity 'oxygen' named entity 'CPR' named entity 'cardiac output' named entity 'conduct' named entity 'declines' named entity 'Least' named entity 'CPR' named entity 'oxygen' named entity 'ANIMAL STUDY' named entity 'CONDUCT' named entity 'OBTAINED' named entity 'OPTIMIZE' named entity 'ADJUSTED' named entity 'PIGS' named entity 'ANIMAL RESEARCH' named entity 'PEEP' named entity 'RESEARCH FACILITY' named entity 'INSIGNIFICANT' named entity 'HIGHEST' named entity 'YORKSHIRE' named entity 'CARDIOPULMONARY RESUSCITATION' named entity 'CARDIOPULMONARY' named entity 'HIGHER' named entity 'EFFECT' named entity 'GROUP' named entity 'NOT KNOWN' covid:arg/8fe4ff1ed3d6017f4c892b7e2248489dec378e1d named entity 'cardiac output' named entity 'higher' named entity 'blood pressure' named entity 'end-tidal carbon dioxide' named entity 'flow of blood' named entity 'PEEP' named entity 'cardiac arrest' named entity 'PEEP' named entity 'ultrasound' named entity 'CPR' named entity 'cardiac output' named entity 'respiratory rate' named entity 'Ithaca, New York' named entity 'propofol' named entity 'PEEP' named entity 'lungs' named entity 'PEEP' named entity 'chest compression' named entity 'PEEP' named entity 'Cary, NC' named entity 'cardiac output' named entity 'PEEP' named entity 'LUCAS' named entity 'peripheral vascular resistance' named entity 'pneumonia' named entity 'systolic pressure' named entity 'CPR' named entity 'systemic pressure' named entity 'positive pressure' named entity 'cardiac arrest' named entity 'CPR' named entity 'Arterial blood gas' named entity 'lungs' named entity 'venous return' named entity 'Gaussian mixture model' named entity 'physiology' named entity 'tidal volume' named entity 'analysis of variance' named entity 'afterload' named entity 'CPR' named entity 'intramuscular injections' named entity 'cardiac output' named entity 'pig' named entity 'cardiac output' named entity 'cardiac output' named entity 'PEEP' named entity 'CPR' named entity 'preload' named entity 'heart rate' named entity 'CPR'

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