About: Moving beyond the mousetrap: current and emerging humanized mouse and rat models for investigating prevention and cure strategies against HIV infection and associated pathologies

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About: Moving beyond the mousetrap: current and emerging humanized mouse and rat models for investigating prevention and cure strategies against HIV infection and associated pathologies Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Moving beyond the mousetrap: current and emerging humanized mouse and rat models for investigating prevention and cure strategies against HIV infection and associated pathologies
Creator	Ho, Sara Agarwal, Yash Beatty, Cole Bility, Moses Biradar, Shivkumar Castronova, Isabella Melody, Kevin
Source	PMC
abstract	The development of safe and effective combination antiretroviral therapies for human immunodeficiency virus (HIV) infection over the past several decades has significantly reduced HIV-associated morbidity and mortality. Additionally, antiretroviral drugs have provided an effective means of protection against HIV transmission. Despite these advances, significant limitations exist; namely, the inability to eliminate HIV reservoirs, the inability to reverse lymphoid tissues damage, and the lack of an effective vaccine for preventing HIV transmission. Evaluation of the safety and efficacy of therapeutics and vaccines for eliminating HIV reservoirs and preventing HIV transmission requires robust in vivo models. Since HIV is a human-specific pathogen, that targets hematopoietic lineage cells and lymphoid tissues, in vivo animal models for HIV-host interactions require incorporation of human hematopoietic lineage cells and lymphoid tissues. In this review, we will discuss the construction of mouse models with human lymphoid tissues and/or hematopoietic lineage cells, termed, human immune system (HIS)-humanized mice. These HIS-humanized mouse models can support the development of functional human innate and adaptive immune cells, along with primary (thymus) and secondary (spleen) lymphoid tissues. We will discuss applications of HIS-humanized mouse models in evaluating the safety and efficacy of therapeutics against HIV reservoirs and associated immunopathology, and delineate the human immune response elicited by candidate HIV vaccines. In addition to focusing on how these HIS-humanized mouse models have already furthered our understanding of HIV and contributed to HIV therapeutics development, we discuss how emerging HIS-humanized rat models could address the limitations of HIS-mouse models.
has issue date	2020-04-10(xsd:dateTime)
bibo:doi	10.1186/s12977-020-00515-3
bibo:pmid	32276640
has license	cc-by
sha1sum (hex)	6b2c4588c2f596b011b8a6227a92be89014094fc
schema:url	https://doi.org/10.1186/s12977-020-00515-3
resource representing a document's title	Moving beyond the mousetrap: current and emerging humanized mouse and rat models for investigating prevention and cure strategies against HIV infection and associated pathologies
has PubMed Central identifier	PMC7149862
has PubMed identifier	32276640
schema:publication	Retrovirology
resource representing a document's body	covid:6b2c4588c2f596b011b8a6227a92be89014094fc#body_text
is schema:about of	named entity 'immunopathology' named entity 'efficacy' named entity 'cells' named entity 'termed' named entity 'HIV' named entity 'mouse' named entity 'HIV' named entity 'preventing' named entity 'morbidity' named entity 'HIV' named entity 'evaluating' named entity 'human' named entity 'reservoirs' named entity 'investigating' named entity 'HUMAN IMMUNODEFICIENCY VIRUS' named entity 'REVIEW' named entity 'UNDERSTANDING' named entity 'MODELS' named entity 'FOCUSING' named entity 'PREVENTING' named entity 'DRUGS' named entity 'HUMAN' named entity 'INTERACTIONS' named entity 'PAST' named entity 'combination' named entity 'development' named entity 'therapeutics' named entity 'addition' named entity 'vivo' named entity 'models' named entity 'focusing' named entity 'primary' named entity 'functional' named entity 'effective' named entity 'infection' named entity 'incorporation' named entity 'human' named entity 'antiretroviral drugs' named entity 'safety' named entity 'antiretroviral' named entity 'therapeutics' named entity 'prevention' named entity 'vaccines' named entity 'HIV' named entity 'HIV' named entity 'humanized mouse' named entity 'morbidity' named entity 'lymphoid tissues' named entity 'HIV transmission' named entity 'HIV vaccines' named entity 'mouse models' named entity 'infection' named entity 'human immune system' named entity 'antiretroviral' named entity 'thymus' named entity 'HIV' named entity 'human immune system' named entity 'rat models' named entity 'humanized mouse' named entity 'autologous' named entity 'HSCs' named entity 'non-human primate' named entity 'humanized mice' named entity 'mouse models' named entity 'mouse model' named entity 'pathogen' named entity 'thymus' named entity 'HIV' named entity 'HIV infection' named entity 'macrophages' named entity 'neonatal' named entity 'graft-versus-host' named entity 'PBL' named entity 'autologous' named entity 'Bone marrow'

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