. . . . . . . . . . . "891521"^^ . . . . . . . . . . . . . . . . . . . "\u0397 \u03B1\u03C4\u03B5\u03BB\u03AE\u03C2 \u03BF\u03C3\u03C4\u03B5\u03BF\u03B3\u03AD\u03BD\u03B5\u03C3\u03B7 (Osteogenesis imperfecta, OI) \u03AE \u03BF\u03C3\u03C4\u03B5\u03BF\u03C8\u03B1\u03B8\u03CD\u03C1\u03C9\u03C3\u03B7 \u03B5\u03AF\u03BD\u03B1\u03B9 \u03BC\u03B9\u03B1 \u03B3\u03B5\u03BD\u03B5\u03C4\u03B9\u03BA\u03AE \u03B4\u03B9\u03B1\u03C4\u03B1\u03C1\u03B1\u03C7\u03AE \u03C0\u03BF\u03C5 \u03C7\u03B1\u03C1\u03B1\u03BA\u03C4\u03B7\u03C1\u03AF\u03B6\u03B5\u03C4\u03B1\u03B9 \u03B1\u03C0\u03CC \u03C4\u03B1 \u03BF\u03C3\u03C4\u03AC \u03C0\u03BF\u03C5 \u03C3\u03C0\u03AC\u03B6\u03BF\u03C5\u03BD \u03B5\u03CD\u03BA\u03BF\u03BB\u03B1, \u03C3\u03C5\u03C7\u03BD\u03AC \u03B1\u03C0\u03CC \u03B5\u03BB\u03AC\u03C7\u03B9\u03C3\u03C4\u03B7 \u03AE \u03BA\u03B1\u03BC\u03AF\u03B1 \u03C0\u03C1\u03BF\u03C6\u03B1\u03BD\u03AE \u03B1\u03B9\u03C4\u03AF\u03B1. \u03A5\u03C0\u03AC\u03C1\u03C7\u03BF\u03C5\u03BD \u03C4\u03BF\u03C5\u03BB\u03AC\u03C7\u03B9\u03C3\u03C4\u03BF\u03BD \u03C4\u03AD\u03C3\u03C3\u03B5\u03C1\u03B9\u03C2 \u03B1\u03BD\u03B1\u03B3\u03BD\u03C9\u03C1\u03B9\u03C3\u03BC\u03AD\u03BD\u03B5\u03C2 \u03BC\u03BF\u03C1\u03C6\u03AD\u03C2 \u03C4\u03B7\u03C2 \u03B4\u03B9\u03B1\u03C4\u03B1\u03C1\u03B1\u03C7\u03AE\u03C2, \u03C0\u03BF\u03C5 \u03C0\u03B1\u03C1\u03BF\u03C5\u03C3\u03B9\u03AC\u03B6\u03BF\u03C5\u03BD \u03BC\u03B5\u03B3\u03AC\u03BB\u03B7 \u03B4\u03B9\u03B1\u03BA\u03CD\u03BC\u03B1\u03BD\u03C3\u03B7 \u03C3\u03C4\u03B7\u03BD \u03C3\u03BF\u03B2\u03B1\u03C1\u03CC\u03C4\u03B7\u03C4\u03B1 \u03C4\u03B7\u03C2 \u03B1\u03C3\u03B8\u03AD\u03BD\u03B5\u03B9\u03B1\u03C2 \u03B1\u03C0\u03CC \u03AC\u03C4\u03BF\u03BC\u03BF \u03C3\u03B5 \u03AC\u03C4\u03BF\u03BC\u03BF. \u03A0\u03B1\u03C1\u03B1\u03B4\u03B5\u03AF\u03B3\u03BC\u03B1\u03C4\u03BF\u03C2 \u03C7\u03AC\u03C1\u03B9\u03BD, \u03AD\u03BD\u03B1 \u03AC\u03C4\u03BF\u03BC\u03BF \u03BC\u03B5 \u03B1\u03C4\u03B5\u03BB\u03AE \u03BF\u03C3\u03C4\u03B5\u03BF\u03B3\u03AD\u03BD\u03B5\u03C3\u03B7 \u03BC\u03C0\u03BF\u03C1\u03B5\u03AF \u03BD\u03B1 \u03AD\u03C7\u03B5\u03B9 \u03BC\u03CC\u03BD\u03BF \u03BC\u03B5\u03C1\u03B9\u03BA\u03AC \u03AE \u03BA\u03B1\u03B9 \u03B5\u03BA\u03B1\u03C4\u03BF\u03BD\u03C4\u03AC\u03B4\u03B5\u03C2 \u03BA\u03B1\u03C4\u03AC\u03B3\u03BC\u03B1\u03C4\u03B1 \u03C3\u03C4\u03B7 \u03B4\u03B9\u03AC\u03C1\u03BA\u03B5\u03B9\u03B1 \u03C4\u03B7\u03C2 \u03B6\u03C9\u03AE\u03C2 \u03C4\u03BF\u03C5. \u0395\u03BD\u03CE \u03BF \u03B1\u03C1\u03B9\u03B8\u03BC\u03CC\u03C2 \u03B1\u03BD\u03B8\u03C1\u03CE\u03C0\u03C9\u03BD \u03C0\u03BF\u03C5 \u03B5\u03C0\u03B7\u03C1\u03B5\u03AC\u03B6\u03BF\u03BD\u03C4\u03B1\u03B9 \u03BC\u03B5 \u03B1\u03C4\u03B5\u03BB\u03AE \u03BF\u03C3\u03C4\u03B5\u03BF\u03B3\u03AD\u03BD\u03B5\u03C3\u03B7 \u03C3\u03C4\u03B9\u03C2 \u0397\u03BD\u03C9\u03BC\u03AD\u03BD\u03B5\u03C2 \u03A0\u03BF\u03BB\u03B9\u03C4\u03B5\u03AF\u03B5\u03C2 \u03B5\u03AF\u03BD\u03B1\u03B9 \u03AC\u03B3\u03BD\u03C9\u03C3\u03C4\u03BF\u03C2, \u03B7 \u03BA\u03B1\u03BB\u03CD\u03C4\u03B5\u03C1\u03B7 \u03B5\u03BA\u03C4\u03AF\u03BC\u03B7\u03C3\u03B7 \u03C0\u03C1\u03BF\u03C4\u03B5\u03AF\u03BD\u03B5\u03B9 \u03C4\u03BF\u03C5\u03BB\u03AC\u03C7\u03B9\u03C3\u03C4\u03BF\u03BD 20.000 \u03BA\u03B1\u03B9 \u03B5\u03BD\u03B4\u03B5\u03C7\u03BF\u03BC\u03AD\u03BD\u03C9\u03C2 \u03C4\u03CC\u03C3\u03BF \u03C0\u03BF\u03BB\u03BB\u03AC \u03CC\u03C0\u03C9\u03C2 50.000 \u03AC\u03C4\u03BF\u03BC\u03B1."@el . . . "Osteogenesis imperfecta (Abk\u00FCrzung OI; altgriechisch \u1F40\u03C3\u03C4\u03AD\u03BF\u03BD ost\u00E9on, deutsch \u201AKnochen\u2018, \u03B3\u03AD\u03BD\u03B5\u03C3\u03B9\u03C2 g\u00E9nesis, deutsch \u201AEntstehung\u2018 und lateinisch imperfecta \u201Aunvollkommen\u2018) wird umgangssprachlich auch als Glasknochenkrankheit bezeichnet, da die Knochen leicht zerbrechlich sind und im R\u00F6ntgenbild eine glasige Struktur aufweisen. Die OI ist eine seltene Erbkrankheit, f\u00FCr die \u00FCberwiegend autosomal-dominante, seltener auch autosomal-rezessive Erbg\u00E4nge beschrieben sind. Hauptmerkmal der OI ist das ver\u00E4nderte Kollagen vom Typ I, was zu einer abnorm hohen Knochenbr\u00FCchigkeit mit unterschiedlichen Krankheitsbildern f\u00FChrt. Unter Betroffenen wird der Begriff \u201EGlasknochenkrankheit\u201C tendenziell abgelehnt, da die OI f\u00FCr sie eher eine Behinderung als eine Erkrankung darstellt. Man spricht in diesem Zusammenhang von \u201EGlasknochen haben\u201C."@de . . . . "Willem Vrolik's specimen of an infant with osteogenesis imperfecta.jpg"@en . . . . . "383"^^ . . . . . . . . . . "Wrodzona \u0142amliwo\u015B\u0107 ko\u015Bci (samoistna \u0142amliwo\u015B\u0107 ko\u015Bci, kostnienie niezupe\u0142ne, \u0142ac. osteogenesis imperfecta, ang. osteogenesis imperfecta, OI) \u2013 grupa chor\u00F3b uwarunkowanych genetycznie, polegaj\u0105cych na zaburzeniach w prawid\u0142owej budowie kolagenu (g\u0142\u00F3wnego sk\u0142adnika tkanki \u0142\u0105cznej). Choroby te objawiaj\u0105 si\u0119 nadmiern\u0105 krucho\u015Bci\u0105 ko\u015Bci."@pl . . . . . . . . . . . "X-ray of osteogenesis imperfecta type 5 in newborn - right leg.jpg"@en . . . . . . . . . . . . . . . . "Osteogenesis imperfecta is highly variable, affecting all those above."@en . . . . . . "Bones that break easily, blue tinge to the sclera , short height, joint hypermobility, hearing loss"@en . . "001573" . "L\u2019ost\u00E9ogen\u00E8se imparfaite, appel\u00E9e aussi \u00AB maladie des os de verre \u00BB, est un groupe de maladies caract\u00E9ris\u00E9es par une fragilit\u00E9 osseuse excessive, due \u00E0 un d\u00E9faut cong\u00E9nital d\u2019\u00E9laboration des fibres collag\u00E8nes du tissu conjonctif qui forme la trame de l\u2019os. Tous les types se caract\u00E9risent par une extr\u00EAme fragilit\u00E9 des os, signe le plus typique de la maladie. Cependant, tous les tissus contenant du collag\u00E8ne sont aussi touch\u00E9s (os, peau, tendon). La plupart du temps cette maladie est due \u00E0 une mutation g\u00E9n\u00E9tique spontan\u00E9e de novo mais elle peut aussi \u00EAtre familiale et transmise par seulement l\u2019un des deux parents (transmission autosomique dominante)."@fr . . . . . . . . . . . "Based on symptoms, DNA testing"@en . "Wrodzona \u0142amliwo\u015B\u0107 ko\u015Bci"@pl . . . "666"^^ . . . . . . "Wrodzona \u0142amliwo\u015B\u0107 ko\u015Bci (samoistna \u0142amliwo\u015B\u0107 ko\u015Bci, kostnienie niezupe\u0142ne, \u0142ac. osteogenesis imperfecta, ang. osteogenesis imperfecta, OI) \u2013 grupa chor\u00F3b uwarunkowanych genetycznie, polegaj\u0105cych na zaburzeniach w prawid\u0142owej budowie kolagenu (g\u0142\u00F3wnego sk\u0142adnika tkanki \u0142\u0105cznej). Choroby te objawiaj\u0105 si\u0119 nadmiern\u0105 krucho\u015Bci\u0105 ko\u015Bci."@pl . . . . "\u6210\u9AA8\u4E0D\u5168\u75C7"@zh . "Four X-rays of a 24-year-old American man, who had had more than one hundred bone fractures in his lifetime, and received a childhood clinical diagnosis of [[#Type IV"@en . . . . "Osteogenesis imperfecta (OI, n\u011Bkdy naz\u00FDv\u00E1no nemoc k\u0159ehk\u00FDch kost\u00ED) je genetick\u00E1 kostn\u00ED porucha. Lid\u00E9 s OI se rod\u00ED s defektn\u00ED pojivovou tk\u00E1n\u00ED, nebo bez schopnosti ji vytvo\u0159it, obvykle kv\u016Fli nedostatku kolagenu typu I."@cs . . . . . . . . . . . "1"^^ . . . . . . . . "250"^^ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Osteogenesis imperfecta (OI) of brozebottenziekte is een zeldzame, aangeboren en erfelijke bindweefselaandoening, die met name gekenmerkt is door zeer broze botten. Door een genmutatie is de hoeveelheid en/of de samenstelling van het collageen type 1 (meestal) afwijkend."@nl . . . . . . "Osteogenesis imperfecta (IPA: /\u02CC\u0252stio\u028A\u02C8d\u0292\u025Bn\u0259s\u026As \u02CC\u026Amp\u025C\u02D0r\u02C8f\u025Bkt\u0259/; OI), colloquially known as brittle bone disease, is a group of genetic disorders that all result in bones that break easily. The range of symptoms\u2014on the skeleton as well as on the body's other organs\u2014may be mild to severe. Symptoms found in various types of OI include whites of the eye (sclerae) that are blue instead, short stature, loose joints, hearing loss, breathing problems and problems with the teeth (dentinogenesis imperfecta). Potentially life-threatening complications, all of which become more common in more severe OI, include: tearing (dissection) of the major arteries, such as the aorta; pulmonary valve insufficiency secondary to distortion of the ribcage; and basilar invagination."@en . . . . . . . . . . . . . . ""@en . . "Right femur"@en . . . . . . . . . . . . . . . . . . . . . . . . . . . . "L'osteog\u00E8nesi imperfecta (tamb\u00E9 anomenada malaltia dels ossos de vidre) \u00E9s un trastorn cong\u00E8nit, \u00E9s a dir, present en n\u00E9ixer, que es caracteritza per una fragilitat d'os excessiva, com a conseq\u00FC\u00E8ncia d'una defici\u00E8ncia cong\u00E8nita en l'elaboraci\u00F3 d'una prote\u00EFna, el col\u00B7lagen tipus I. Els qui porten el defecte tenen menys col\u00B7lagen del normal o \u00E9s d'una menor qualitat i com \u00E9s una prote\u00EFna important en l'estructura dels ossos, causa una fragilitat i debilitat poc usual dels ossos. El diagn\u00F2stic \u00E9s radiol\u00F2gic, fins i tot abans del part."@ca . . . . . . . "Right forearm"@en . . . . . . . . . . . . . . . . . . . . . . "666" . . . . . . . . . . . . . . . . . "\u9AA8\u5F62\u6210\u4E0D\u5168\u75C7"@ja . . "Nicolas de Malebranche is thought to be the first person to attempt to describe the clinical features of OI."@en . . . . "Jean Georges Chr\u00E9tien Fr\u00E9d\u00E9ric Martin Lobstein .jpg"@en . . . . . . . . . . . . . . . . . . "Osteog\u00E9nese imperfeita (portugu\u00EAs europeu) ou Osteog\u00EAnese imperfeita (portugu\u00EAs brasileiro), osteogenesis imperfecta ou doen\u00E7a de Ekman-Lobstein (do latim, osteo- osso; -genesis forma\u00E7\u00E3o; imperfecta, imperfeita) ou Ossos de vidro \u00E9 um grupo de doen\u00E7as gen\u00E9ticas raras caracterizadas por ossos e dentes fr\u00E1geis. A severidade da doen\u00E7a depende dos genes afetados. Existem 9 tipos identificados dessa doen\u00E7a. As formas severa e moderada da doen\u00E7a podem ser diagnosticadas logo no nascimento, ou mesmo antes do nascimento, e s\u00E3o encontradas em cerca de 5 por 100.000 rec\u00E9m-nascidos. Os pacientes com esta enfermidade nascem com um problema (muta\u00E7\u00E3o ou aus\u00EAncia de uma das enzimas necess\u00E1rias) na forma\u00E7\u00E3o de col\u00E1geno tipo 1. Esse col\u00E1geno \u00E9 um importante componente da estrutura dos ossos. Muitas crian\u00E7as com osteog\u00EAnese imperfeita nascem com fraturas, sofrem deformidades e n\u00E3o sobrevivem a idade adulta. Aquelas que sobrevivem, sofrem diversas fraturas, t\u00EAm baixa estatura, problemas respirat\u00F3rios, auditivos e odontol\u00F3gicos. As fraturas podem ocorrer mesmo sem causa aparente. Por\u00E9m a capacidade cognitiva, sensitiva e emocional \u00E9 normal."@pt . . . "Osteogenesis_imperfecta_X-ray__of_right_arm.png"@en . . . . . . . . . . "Galar d\u00FAchasach creatlaigh ina dtarla\u00EDonn foirmi\u00FA easnamhach na gcn\u00E1mh is na bhf\u00EDoch\u00E1in taca\u00EDochta ionas go mb\u00EDonn an creatlach an-bhriosc sobhriste. M\u00E1 bh\u00EDonn an neamhord an-dian, is f\u00E9idir go bhfulaingeoidh na\u00EDon\u00E1n an iliomad brist\u00ED diana cn\u00E1imhe is go bhfaighidh b\u00E1s ina leanbh. Muna mb\u00EDonn s\u00E9 r\u00F3dhian, is f\u00E9idir go mairfidh s\u00E9 go mbeidh s\u00E9 f\u00E1sta ach go bhfulaingeoidh briseadh cn\u00E1imhe \u00F3 am go ch\u00E9ile, sna g\u00E9aga \u00EDochtaracha go h\u00E1irithe. Uaireanta, tarla\u00EDonn crand\u00FA is dath\u00FA gorm ar scl\u00E9ara\u00ED na s\u00FAl do na p\u00E1ist\u00ED seo."@ga . . "10"^^ . "L'osteogenesi imperfetta \u00E8 una malattia genetica a trasmissione autosomica dominante per anomalie nella sintesi del collagene tipo I per mutazione dei geni Col1A1 e 2. Crea problemi a carico dello scheletro, delle articolazioni, degli occhi, delle orecchie, della cute e dei denti. I fenotipi pi\u00F9 gravi o letali sono la conseguenza di difetti genetici, che determinano molecole anomale di collagene che non riescono a formare la tripla elica."@it . . . "La osteog\u00E9nesis imperfecta u osteogenia imperfecta (tambi\u00E9n llamada enfermedad de los huesos de cristal) es un trastorno cong\u00E9nito, es decir, presente al nacer, que se caracteriza por una fragilidad de hueso excesiva, como consecuencia de una deficiencia cong\u00E9nita en la elaboraci\u00F3n de una prote\u00EDna, el col\u00E1geno tipo I. Quienes portan el defecto tienen menos col\u00E1geno de lo normal o es de una menor calidad y como es una prote\u00EDna importante en la estructura de los huesos, causa una fragilidad y debilidad poco usual de los huesos.\u200B El diagn\u00F3stico es radiol\u00F3gico, incluso antes del parto.\u200B\u200B"@es . . . . . . . . . "XrayOITypeV-Kid.jpg"@en . . . . . . . . . . . . "vertical"@en . "The tip of a modern Fassier\u2013Duval telescoping intramedullary rod, manufactured by Pega Medical for use in osteogenesis imperfecta."@en . . . "ped"@en . . . . "151306"^^ . . . "Vrolik, W..jpg"@en . . . . . . . . . . . . . . . . "Osteogenesis imperfecta (ostogenezo malperfekta) (OM kaj alinome OI, la sindromo de Lobstein kaj malforta osto malsano) estas malsano de osto denaska. \u011Ci karakterizi\u011Das pro ostoj malfortaj kiuj facile rompi\u011Das. Homoj kun OM naski\u011Das kun kuniga histo mankohava, a\u016D sen la kapablo produkti \u011Din, kutime ka\u016Dztaas de deficito de kolageno de tipo I. Ok tipoj de OM povas distingi\u011Di. La plimulto de kazoj estas kauzata per mutacioj en la kaj genoj."@eo . "Osteogenesis imperfecta (OI), atau dikenal juga dengan sebutan penyakit tulang rapuh, merupakan kelompok kelainan genetik yang secara khusus memengaruhi kondisi tulang manusia. Penyakit ini dapat menyebabkan tulang sangat mudah patah, dan tingkat keparahan bisa dalam stadium rendah dengan risiko rendah hingga stadium tinggi dengan risiko paling berat. Gejala lain yang bisa terjadi ialah adanya semburat biru pada bagian putih mata, tinggi badan yang pendek, , mengalami , terjadi masalah pada pernapasan, dan juga dapat menimbulkan masalah dengan gigi. Gejala komplikasi juga bisa terjadi yakni dan juga diseksi aorta. Mekanisme yang mendasari penyakit ini umumnya adalah masalah jaringan ikat karena kurangnya , dan ini menimpa lebih dari 90% kasus disebabkan oleh terjadinya mutasi pada gen atau pada . Penyakit ini juga bisa disebabkan melalui genetik atau kelainan bawaan yang umumnya diwarisi melalui orang tua dengan cara atau melalui mutasi baru. Ada delapan tipe penyakit OI ini, mulai dari tipe I menjadi yang paling parah dan tipe II yang paling parah. Untuk meniagnosa kasus penyakit ini dapat merujuk pada gejala yang terjadi dan untuk memastikannya dapat dilakukan kolagen atau pengujian DNA. Hingga saat ini belum ada yang dapat menyembuhkan penyakit ini. Cara utama yang perlu dilakukan supaya terhindar dari penyakit patah tulang ialah menjaga pola hidup yang sehat dengan melakukan olahraga rutin dan tidak merokok. Sementara untuk penanganan bagi penderita OI, perawatan dapat dilakukan dengan terapi patah tulang, pengobatan nyeri sendi, , penggunaan kawat gigi atau kursi roda dan bisa masuk pada tahap operasi. Pengobatan menggunakan operasi dengan memasang batang logam melalui tulang panjang untuk memperkuat tulang rapuh. Pengobatan juga bisa dengan mengonsumsi obat-obatan tipe . Patah tulang OI diidap oleh 1 dari 15,000 orang. Tingkat keparahan penyakit tergantung pada jenis penyakit. Istilah \"osteogenesis imperfecta\" mulai diakai pada tahun 1895 yang diartikan sebagai pembentukan tulang yang tidak sempurna."@in . . . . . . . . "Osteogenesis imperfecta (OI) \u00E4r en genetisk sjukdom som beror p\u00E5 en mutation i genen f\u00F6r kollagen. Sjukdomen \u00E4r \u00E4rftlig och inneb\u00E4r framf\u00F6rallt olika grader av bensk\u00F6rhet. De som drabbas av de sv\u00E5rare formerna d\u00F6r i sp\u00E4dbarnsstadiet medan de lindrigast drabbade lever ett helt normalt liv, med n\u00E5got fler benbrott \u00E4n andra. Det inneb\u00E4r att inom sjukdomen finns allt fr\u00E5n sv\u00E5rt handikappade till fullt arbetsf\u00F6ra personer. De flesta besv\u00E4ras dock av n\u00E5gon form av v\u00E4rk oavsett form av sjukdomen. Idag delar man in sjukdomen i fyra grupper: typ I, typ II, typ III och typ IV. Den vanligaste typen \u00E4r typ I, som st\u00E5r f\u00F6r cirka 70 % av sjukdomsfallen."@sv . . . . . . . . . "Osteogenesis imperfecta"@nl . . "\u0397 \u03B1\u03C4\u03B5\u03BB\u03AE\u03C2 \u03BF\u03C3\u03C4\u03B5\u03BF\u03B3\u03AD\u03BD\u03B5\u03C3\u03B7 (Osteogenesis imperfecta, OI) \u03AE \u03BF\u03C3\u03C4\u03B5\u03BF\u03C8\u03B1\u03B8\u03CD\u03C1\u03C9\u03C3\u03B7 \u03B5\u03AF\u03BD\u03B1\u03B9 \u03BC\u03B9\u03B1 \u03B3\u03B5\u03BD\u03B5\u03C4\u03B9\u03BA\u03AE \u03B4\u03B9\u03B1\u03C4\u03B1\u03C1\u03B1\u03C7\u03AE \u03C0\u03BF\u03C5 \u03C7\u03B1\u03C1\u03B1\u03BA\u03C4\u03B7\u03C1\u03AF\u03B6\u03B5\u03C4\u03B1\u03B9 \u03B1\u03C0\u03CC \u03C4\u03B1 \u03BF\u03C3\u03C4\u03AC \u03C0\u03BF\u03C5 \u03C3\u03C0\u03AC\u03B6\u03BF\u03C5\u03BD \u03B5\u03CD\u03BA\u03BF\u03BB\u03B1, \u03C3\u03C5\u03C7\u03BD\u03AC \u03B1\u03C0\u03CC \u03B5\u03BB\u03AC\u03C7\u03B9\u03C3\u03C4\u03B7 \u03AE \u03BA\u03B1\u03BC\u03AF\u03B1 \u03C0\u03C1\u03BF\u03C6\u03B1\u03BD\u03AE \u03B1\u03B9\u03C4\u03AF\u03B1. \u03A5\u03C0\u03AC\u03C1\u03C7\u03BF\u03C5\u03BD \u03C4\u03BF\u03C5\u03BB\u03AC\u03C7\u03B9\u03C3\u03C4\u03BF\u03BD \u03C4\u03AD\u03C3\u03C3\u03B5\u03C1\u03B9\u03C2 \u03B1\u03BD\u03B1\u03B3\u03BD\u03C9\u03C1\u03B9\u03C3\u03BC\u03AD\u03BD\u03B5\u03C2 \u03BC\u03BF\u03C1\u03C6\u03AD\u03C2 \u03C4\u03B7\u03C2 \u03B4\u03B9\u03B1\u03C4\u03B1\u03C1\u03B1\u03C7\u03AE\u03C2, \u03C0\u03BF\u03C5 \u03C0\u03B1\u03C1\u03BF\u03C5\u03C3\u03B9\u03AC\u03B6\u03BF\u03C5\u03BD \u03BC\u03B5\u03B3\u03AC\u03BB\u03B7 \u03B4\u03B9\u03B1\u03BA\u03CD\u03BC\u03B1\u03BD\u03C3\u03B7 \u03C3\u03C4\u03B7\u03BD \u03C3\u03BF\u03B2\u03B1\u03C1\u03CC\u03C4\u03B7\u03C4\u03B1 \u03C4\u03B7\u03C2 \u03B1\u03C3\u03B8\u03AD\u03BD\u03B5\u03B9\u03B1\u03C2 \u03B1\u03C0\u03CC \u03AC\u03C4\u03BF\u03BC\u03BF \u03C3\u03B5 \u03AC\u03C4\u03BF\u03BC\u03BF. \u03A0\u03B1\u03C1\u03B1\u03B4\u03B5\u03AF\u03B3\u03BC\u03B1\u03C4\u03BF\u03C2 \u03C7\u03AC\u03C1\u03B9\u03BD, \u03AD\u03BD\u03B1 \u03AC\u03C4\u03BF\u03BC\u03BF \u03BC\u03B5 \u03B1\u03C4\u03B5\u03BB\u03AE \u03BF\u03C3\u03C4\u03B5\u03BF\u03B3\u03AD\u03BD\u03B5\u03C3\u03B7 \u03BC\u03C0\u03BF\u03C1\u03B5\u03AF \u03BD\u03B1 \u03AD\u03C7\u03B5\u03B9 \u03BC\u03CC\u03BD\u03BF \u03BC\u03B5\u03C1\u03B9\u03BA\u03AC \u03AE \u03BA\u03B1\u03B9 \u03B5\u03BA\u03B1\u03C4\u03BF\u03BD\u03C4\u03AC\u03B4\u03B5\u03C2 \u03BA\u03B1\u03C4\u03AC\u03B3\u03BC\u03B1\u03C4\u03B1 \u03C3\u03C4\u03B7 \u03B4\u03B9\u03AC\u03C1\u03BA\u03B5\u03B9\u03B1 \u03C4\u03B7\u03C2 \u03B6\u03C9\u03AE\u03C2 \u03C4\u03BF\u03C5."@el . . . "Osteogenesis imperfecta"@en . . . . . . "Brittle bone disease, Lobstein syndrome, fragilitas ossium, Vrolik disease, osteopsathyrosis idiopathica"@en . . . "Osteogenesis imperfecta"@eo . . . "Osteogenesis imperfecta"@de . . . . . . . . . . . . . . . . . . . . . . . . . "Osteogenesi inperfektu"@eu . . "Brittle bone disease, Lobstein syndrome,fragilitas ossium, Vrolik disease,osteopsathyrosis idiopathica"@en . . . . . . . . . . "L'osteogenesi imperfetta \u00E8 una malattia genetica a trasmissione autosomica dominante per anomalie nella sintesi del collagene tipo I per mutazione dei geni Col1A1 e 2. Crea problemi a carico dello scheletro, delle articolazioni, degli occhi, delle orecchie, della cute e dei denti. I fenotipi pi\u00F9 gravi o letali sono la conseguenza di difetti genetici, che determinano molecole anomale di collagene che non riescono a formare la tripla elica."@it . . . . "Osteogenesis imperfecta (OI) of brozebottenziekte is een zeldzame, aangeboren en erfelijke bindweefselaandoening, die met name gekenmerkt is door zeer broze botten. Door een genmutatie is de hoeveelheid en/of de samenstelling van het collageen type 1 (meestal) afwijkend."@nl . . . . . . . . . . . . . . . . . . . . "1573"^^ . . . . . . . . "\uACE8\uD615\uC131\uBD80\uC804\uC99D(\u9AA8\u5F62\u6210\u4E0D\u5168\u75C7, osteogenesis imperfecta, OI)\uC740 \uBF08\uC5D0 \uC8FC\uB85C \uC601\uD5A5\uC744 \uBBF8\uCE58\uB294 \uC720\uC804\uBCD1\uC758 \uADF8\uB8F9\uC774\uB2E4. \uBD88\uC644\uC804 \uACE8\uD615\uC131\uC99D(\u4E0D\u5B8C\u5168\u9AA8\u5F62\u6210\u75C7), \uACE8\uBD88\uC644\uC804\uD615\uC131\uC99D(\u9AA8\u4E0D\u5B8C\u5168\u5F62\u6210\u75C7)\uC774\uB77C\uACE0\uB3C4 \uD55C\uB2E4. \uACE8\uC808\uC744 \uC27D\uAC8C \uC77C\uC73C\uD0A8\uB2E4. \uC2EC\uAC01\uB3C4\uB294 \uC628\uD654\uD55C \uC815\uB3C4\uC5D0\uC11C \uADF9\uC2EC\uD55C \uC815\uB3C4\uC5D0\uAE4C\uC9C0 \uC774\uB978\uB2E4. \uC99D\uC0C1\uC5D0\uB294 \uB208\uC758 \uD30C\uB780 \uACF5\uB9C9, \uC791\uC740 \uD0A4, \uAD00\uC808 \uACFC\uAC00\uB3D9\uC131, \uCCAD\uAC01 \uC7A5\uC560, \uD638\uD761 \uBB38\uC81C, \uCE58\uC544 \uBB38\uC81C\uB97C \uD3EC\uD568\uD560 \uC218 \uC788\uB2E4."@ko . . . . . . . . . . . . . . . . . . . . . . "\u041D\u0435\u0441\u043E\u0432\u0435\u0440\u0448\u0435\u0301\u043D\u043D\u044B\u0439 \u043E\u0441\u0442\u0435\u043E\u0433\u0435\u043D\u0435\u0301\u0437 (\u041D\u041E) (\u043B\u0430\u0442. osteogenesis imperfecta; \u0438\u043D\u0430\u0447\u0435 \u00AB\u043D\u0435\u0441\u043E\u0432\u0435\u0440\u0448\u0435\u043D\u043D\u043E\u0435 \u043A\u043E\u0441\u0442\u0435\u043E\u0431\u0440\u0430\u0437\u043E\u0432\u0430\u043D\u0438\u0435\u00BB, \u0431\u043E\u043B\u0435\u0437\u043D\u044C \u00AB\u0445\u0440\u0443\u0441\u0442\u0430\u043B\u044C\u043D\u043E\u0433\u043E \u0447\u0435\u043B\u043E\u0432\u0435\u043A\u0430\u00BB, \u0431\u043E\u043B\u0435\u0437\u043D\u044C \u041B\u043E\u0431\u0448\u0442\u0435\u0439\u043D\u0430 \u2014 \u0412\u0440\u043E\u043B\u0438\u043A\u0430) \u2014 \u0433\u0440\u0443\u043F\u043F\u0430 \u0433\u0435\u043D\u0435\u0442\u0438\u0447\u0435\u0441\u043A\u0438\u0445 \u043D\u0430\u0440\u0443\u0448\u0435\u043D\u0438\u0439. \u041E\u0434\u043D\u043E \u0438\u0437 \u0437\u0430\u0431\u043E\u043B\u0435\u0432\u0430\u043D\u0438\u0439, \u0445\u0430\u0440\u0430\u043A\u0442\u0435\u0440\u0438\u0437\u0443\u044E\u0449\u0435\u0435\u0441\u044F \u043F\u043E\u0432\u044B\u0448\u0435\u043D\u043D\u043E\u0439 \u043B\u043E\u043C\u043A\u043E\u0441\u0442\u044C\u044E \u043A\u043E\u0441\u0442\u0435\u0439. \u0411\u043E\u043B\u044C\u043D\u044B\u0435 \u043B\u0438\u0431\u043E \u0438\u043C\u0435\u044E\u0442 \u043D\u0435\u0434\u043E\u0441\u0442\u0430\u0442\u043E\u0447\u043D\u043E\u0435 \u043A\u043E\u043B\u0438\u0447\u0435\u0441\u0442\u0432\u043E \u043A\u043E\u043B\u043B\u0430\u0433\u0435\u043D\u0430, \u043B\u0438\u0431\u043E \u0435\u0433\u043E \u043A\u0430\u0447\u0435\u0441\u0442\u0432\u043E \u043D\u0435 \u0441\u043E\u043E\u0442\u0432\u0435\u0442\u0441\u0442\u0432\u0443\u0435\u0442 \u043D\u043E\u0440\u043C\u0435. \u0422\u0430\u043A \u043A\u0430\u043A \u043A\u043E\u043B\u043B\u0430\u0433\u0435\u043D \u2014 \u0432\u0430\u0436\u043D\u044B\u0439 \u0431\u0435\u043B\u043E\u043A \u0432 \u0441\u0442\u0440\u0443\u043A\u0442\u0443\u0440\u0435 \u043A\u043E\u0441\u0442\u0438, \u044D\u0442\u043E \u0437\u0430\u0431\u043E\u043B\u0435\u0432\u0430\u043D\u0438\u0435 \u0432\u043B\u0435\u0447\u0451\u0442 \u0437\u0430 \u0441\u043E\u0431\u043E\u0439 \u0441\u043B\u0430\u0431\u044B\u0435 \u0438\u043B\u0438 \u043B\u043E\u043C\u043A\u0438\u0435 \u043A\u043E\u0441\u0442\u0438. \u0411\u0443\u0434\u0443\u0447\u0438 \u0433\u0435\u043D\u0435\u0442\u0438\u0447\u0435\u0441\u043A\u0438\u043C \u043D\u0430\u0440\u0443\u0448\u0435\u043D\u0438\u0435\u043C, \u041D\u041E \u044F\u0432\u043B\u044F\u0435\u0442\u0441\u044F \u0430\u0443\u0442\u043E\u0441\u043E\u043C\u043D\u043E-\u0434\u043E\u043C\u0438\u043D\u0430\u043D\u0442\u043D\u044B\u043C \u0434\u0435\u0444\u0435\u043A\u0442\u043E\u043C, \u0432 \u0431\u043E\u043B\u044C\u0448\u0438\u043D\u0441\u0442\u0432\u0435 \u043F\u0435\u0440\u0435\u0434\u0430\u043D\u043D\u044B\u043C \u043F\u043E \u043D\u0430\u0441\u043B\u0435\u0434\u0441\u0442\u0432\u0443 \u043E\u0442 \u0440\u043E\u0434\u0438\u0442\u0435\u043B\u0435\u0439, \u043E\u0434\u043D\u0430\u043A\u043E, \u0432\u043E\u0437\u043C\u043E\u0436\u043D\u0430 \u0438 \u0438\u043D\u0434\u0438\u0432\u0438\u0434\u0443\u0430\u043B\u044C\u043D\u0430\u044F \u0441\u043F\u043E\u043D\u0442\u0430\u043D\u043D\u0430\u044F \u043C\u0443\u0442\u0430\u0446\u0438\u044F."@ru . . . . . "Healthy lifestyle , metal rods through the long bones"@en . . . . . . . . . . . "1674"^^ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Osteogenesis_imperfecta_X-ray__of_spine,_chest,_and_pelvis.png"@en . . . . . . . . . "756.51"^^ . . "Q78.0"@en . . . . "AtticusShafferHWOFMay2012.jpg"@en . . . ""@en . "Osteog\u00E9nese imperfeita"@pt . "\u041D\u0435\u0441\u043E\u0432\u0435\u0440\u0448\u0435\u0301\u043D\u043D\u044B\u0439 \u043E\u0441\u0442\u0435\u043E\u0433\u0435\u043D\u0435\u0301\u0437 (\u041D\u041E) (\u043B\u0430\u0442. osteogenesis imperfecta; \u0438\u043D\u0430\u0447\u0435 \u00AB\u043D\u0435\u0441\u043E\u0432\u0435\u0440\u0448\u0435\u043D\u043D\u043E\u0435 \u043A\u043E\u0441\u0442\u0435\u043E\u0431\u0440\u0430\u0437\u043E\u0432\u0430\u043D\u0438\u0435\u00BB, \u0431\u043E\u043B\u0435\u0437\u043D\u044C \u00AB\u0445\u0440\u0443\u0441\u0442\u0430\u043B\u044C\u043D\u043E\u0433\u043E \u0447\u0435\u043B\u043E\u0432\u0435\u043A\u0430\u00BB, \u0431\u043E\u043B\u0435\u0437\u043D\u044C \u041B\u043E\u0431\u0448\u0442\u0435\u0439\u043D\u0430 \u2014 \u0412\u0440\u043E\u043B\u0438\u043A\u0430) \u2014 \u0433\u0440\u0443\u043F\u043F\u0430 \u0433\u0435\u043D\u0435\u0442\u0438\u0447\u0435\u0441\u043A\u0438\u0445 \u043D\u0430\u0440\u0443\u0448\u0435\u043D\u0438\u0439. \u041E\u0434\u043D\u043E \u0438\u0437 \u0437\u0430\u0431\u043E\u043B\u0435\u0432\u0430\u043D\u0438\u0439, \u0445\u0430\u0440\u0430\u043A\u0442\u0435\u0440\u0438\u0437\u0443\u044E\u0449\u0435\u0435\u0441\u044F \u043F\u043E\u0432\u044B\u0448\u0435\u043D\u043D\u043E\u0439 \u043B\u043E\u043C\u043A\u043E\u0441\u0442\u044C\u044E \u043A\u043E\u0441\u0442\u0435\u0439. \u0411\u043E\u043B\u044C\u043D\u044B\u0435 \u043B\u0438\u0431\u043E \u0438\u043C\u0435\u044E\u0442 \u043D\u0435\u0434\u043E\u0441\u0442\u0430\u0442\u043E\u0447\u043D\u043E\u0435 \u043A\u043E\u043B\u0438\u0447\u0435\u0441\u0442\u0432\u043E \u043A\u043E\u043B\u043B\u0430\u0433\u0435\u043D\u0430, \u043B\u0438\u0431\u043E \u0435\u0433\u043E \u043A\u0430\u0447\u0435\u0441\u0442\u0432\u043E \u043D\u0435 \u0441\u043E\u043E\u0442\u0432\u0435\u0442\u0441\u0442\u0432\u0443\u0435\u0442 \u043D\u043E\u0440\u043C\u0435. \u0422\u0430\u043A \u043A\u0430\u043A \u043A\u043E\u043B\u043B\u0430\u0433\u0435\u043D \u2014 \u0432\u0430\u0436\u043D\u044B\u0439 \u0431\u0435\u043B\u043E\u043A \u0432 \u0441\u0442\u0440\u0443\u043A\u0442\u0443\u0440\u0435 \u043A\u043E\u0441\u0442\u0438, \u044D\u0442\u043E \u0437\u0430\u0431\u043E\u043B\u0435\u0432\u0430\u043D\u0438\u0435 \u0432\u043B\u0435\u0447\u0451\u0442 \u0437\u0430 \u0441\u043E\u0431\u043E\u0439 \u0441\u043B\u0430\u0431\u044B\u0435 \u0438\u043B\u0438 \u043B\u043E\u043C\u043A\u0438\u0435 \u043A\u043E\u0441\u0442\u0438."@ru . . . . . . . "L'osteog\u00E8nesi imperfecta (tamb\u00E9 anomenada malaltia dels ossos de vidre) \u00E9s un trastorn cong\u00E8nit, \u00E9s a dir, present en n\u00E9ixer, que es caracteritza per una fragilitat d'os excessiva, com a conseq\u00FC\u00E8ncia d'una defici\u00E8ncia cong\u00E8nita en l'elaboraci\u00F3 d'una prote\u00EFna, el col\u00B7lagen tipus I. Els qui porten el defecte tenen menys col\u00B7lagen del normal o \u00E9s d'una menor qualitat i com \u00E9s una prote\u00EFna important en l'estructura dels ossos, causa una fragilitat i debilitat poc usual dels ossos. El diagn\u00F2stic \u00E9s radiol\u00F2gic, fins i tot abans del part."@ca . . "Osteogenesis imperfecta (IPA: /\u02CC\u0252stio\u028A\u02C8d\u0292\u025Bn\u0259s\u026As \u02CC\u026Amp\u025C\u02D0r\u02C8f\u025Bkt\u0259/; OI), colloquially known as brittle bone disease, is a group of genetic disorders that all result in bones that break easily. The range of symptoms\u2014on the skeleton as well as on the body's other organs\u2014may be mild to severe. Symptoms found in various types of OI include whites of the eye (sclerae) that are blue instead, short stature, loose joints, hearing loss, breathing problems and problems with the teeth (dentinogenesis imperfecta). Potentially life-threatening complications, all of which become more common in more severe OI, include: tearing (dissection) of the major arteries, such as the aorta; pulmonary valve insufficiency secondary to distortion of the ribcage; and basilar invagination. The underlying mechanism is usually a problem with connective tissue due to a lack of, or poorly formed, type I collagen. In more than 90% of cases, OI occurs due to mutations in the COL1A1 or COL1A2 genes. These mutations may be inherited from a person's parents in an autosomal dominant manner but may also occur spontaneously (de novo). There are four clinically defined types: type I, the least severe; type IV, moderately severe; type III, severe and progressively deforming; and type II, perinatally lethal. As of September 2021, 19 different genes are known to cause the 21 documented genetically defined types of OI, many of which are extremely rare and have only been documented in a few individuals. Diagnosis is often based on symptoms and may be confirmed by collagen biopsy or DNA sequencing. Although there is no cure, most cases of OI do not have a major effect on life expectancy, death during childhood from it is rare, and many adults with OI can achieve a significant degree of autonomy despite disability. Maintaining a healthy lifestyle by exercising, eating a balanced diet sufficient in vitamin D and calcium, and avoiding smoking can help prevent fractures. Genetic counseling may be sought by those with OI to prevent their children from inheriting the disorder from them. Treatment may include acute care of broken bones, pain medication, physical therapy, mobility aids such as leg braces and wheelchairs, vitamin D supplementation, and, especially in childhood, rodding surgery. Rodding is an implantation of metal intramedullary rods along the long bones (such as the femur) in an attempt to strengthen them. Medical research also supports the use of medications of the bisphosphonate class, such as pamidronate, to increase bone density. Bisphosphonates are especially effective in children, however it is unclear if they either increase quality of life or decrease the rate of fracture incidence. OI affects only about one in 15,000 to 20,000 people, making it a rare genetic disease. Outcomes depend on the genetic cause of the disorder (its type). Type I (the least severe) is the most common, with other types comprising a minority of cases. Moderate-to-severe OI primarily affects mobility; if rodding surgery is performed during childhood, some of those with more severe types of OI may gain the ability to walk. The condition has been described since ancient history. The Latinate term osteogenesis imperfecta was coined by Dutch anatomist Willem Vrolik in 1849; translated literally, it means \"imperfect bone formation\"."@en . "The right femur and tibia of a 10-year-old girl immediately after her rodding surgery, which involved implantation of the same type of telescoping intramedullary rod photograhed at left. Note the bone fragmentation, an important step in the procedure, clearly visible on the X-ray of the femur."@en . . . . 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"right"@en . . . . . . . "\uACE8\uD615\uC131\uBD80\uC804\uC99D(\u9AA8\u5F62\u6210\u4E0D\u5168\u75C7, osteogenesis imperfecta, OI)\uC740 \uBF08\uC5D0 \uC8FC\uB85C \uC601\uD5A5\uC744 \uBBF8\uCE58\uB294 \uC720\uC804\uBCD1\uC758 \uADF8\uB8F9\uC774\uB2E4. \uBD88\uC644\uC804 \uACE8\uD615\uC131\uC99D(\u4E0D\u5B8C\u5168\u9AA8\u5F62\u6210\u75C7), \uACE8\uBD88\uC644\uC804\uD615\uC131\uC99D(\u9AA8\u4E0D\u5B8C\u5168\u5F62\u6210\u75C7)\uC774\uB77C\uACE0\uB3C4 \uD55C\uB2E4. \uACE8\uC808\uC744 \uC27D\uAC8C \uC77C\uC73C\uD0A8\uB2E4. \uC2EC\uAC01\uB3C4\uB294 \uC628\uD654\uD55C \uC815\uB3C4\uC5D0\uC11C \uADF9\uC2EC\uD55C \uC815\uB3C4\uC5D0\uAE4C\uC9C0 \uC774\uB978\uB2E4. \uC99D\uC0C1\uC5D0\uB294 \uB208\uC758 \uD30C\uB780 \uACF5\uB9C9, \uC791\uC740 \uD0A4, \uAD00\uC808 \uACFC\uAC00\uB3D9\uC131, \uCCAD\uAC01 \uC7A5\uC560, \uD638\uD761 \uBB38\uC81C, \uCE58\uC544 \uBB38\uC81C\uB97C \uD3EC\uD568\uD560 \uC218 \uC788\uB2E4."@ko . . . . . . . . . . "Osteogenesis imperfecta (ostogenezo malperfekta) (OM kaj alinome OI, la sindromo de Lobstein kaj malforta osto malsano) estas malsano de osto denaska. \u011Ci karakterizi\u011Das pro ostoj malfortaj kiuj facile rompi\u011Das. Homoj kun OM naski\u011Das kun kuniga histo mankohava, a\u016D sen la kapablo produkti \u011Din, kutime ka\u016Dztaas de deficito de kolageno de tipo I. Ok tipoj de OM povas distingi\u011Di. La plimulto de kazoj estas kauzata per mutacioj en la kaj genoj. OM diagnozi\u011Das per la simptomoj kaj povas esti konfirmata per kaj testado de kolageno. Ne ekzistas resanigo. Tamen, kuracado povas fortigi la ostojn, preventi la ostrompon kaj konservi la moveblecon. La incideco de OM estas unu de dudek mil naski\u011Doj."@eo . . . 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\u0645\u0645\u0627\u0631\u0633\u0647 \u0627\u0644\u062D\u064A\u0627\u0629 \u0627\u0644\u0637\u0628\u064A\u0639\u064A\u0629. \u0648\u0641\u064A \u0645\u0631\u062D\u0644\u0629 \u0627\u0644\u0645\u0631\u0627\u0647\u0642\u0629 \u062A\u0643\u0648\u0646 \u0627\u0644\u0639\u0638\u0627\u0645 \u0628\u0634\u0643\u0644 \u0639\u0627\u0645 \u0623\u0643\u062B\u0631 \u0639\u0631\u0636\u0629 \u0644\u0644\u0643\u0633\u0631. \u0627\u0644\u0623\u0634\u062E\u0627\u0635 \u0627\u0644\u0645\u0635\u0627\u0628\u0648\u0646 \u0628\u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u0623\u0648\u0644 (I) \u062A\u0643\u0648\u0646 \u0646\u0635\u0641 \u0643\u0645\u064A\u0629 \u0627\u0644\u0643\u0648\u0644\u0627\u062C\u064A\u0646 \u0648\u0628\u0646\u064A\u062A\u0647\u0627 \u0641\u064A \u0623\u062C\u0633\u0627\u062F\u0647\u0645 \u0637\u0628\u064A\u0639\u064A\u0629. \u0623\u0645\u0627 \u0627\u0644\u0623\u0634\u062E\u0627\u0635 \u0627\u0644\u0645\u0635\u0627\u0628\u0648\u0646 \u0628\u0627\u0644\u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0623\u062E\u0631\u0649 (II,III,IV) \u0641\u064A\u0643\u0648\u0646 \u0627\u0644\u0643\u0648\u0644\u0627\u062C\u064A\u0646 \u0641\u064A \u0623\u062C\u0633\u0627\u062F\u0647\u0645 \u063A\u064A\u0631 \u0633\u0644\u064A\u0645 \u0645\u0646 \u062D\u064A\u062B \u0627\u0644\u0643\u0645\u064A\u0629 \u0648\u0627\u0644\u0628\u0646\u064A\u0629."@ar . . . . . . . . . "\u9AA8\u5F62\u6210\u4E0D\u5168\u75C7\uFF08\u3053\u3064\u3051\u3044\u305B\u3044\u3075\u305C\u3093\u3057\u3087\u3046\u3001OI: Osteogenesis Imperfecta\uFF09\u306F\u3001\u6613\u9AA8\u6298\u6027\u30FB\u9032\u884C\u6027\u306E\u9AA8\u5909\u5F62\u306A\u3069\u306E\u9AA8\u8106\u5F31\u6027\u3092\u793A\u3059\u75C5\u72B6\u306B\u52A0\u3048\u3001\u69D8\u3005\u306A\u7A0B\u5EA6\u306E\u7D50\u5408\u7D44\u7E54\u306E\u75C5\u72B6\u3092\u793A\u3059\u5148\u5929\u6027\u306E\u75BE\u60A3\u3067\u3042\u308B\u3002\u5C0F\u5150\u6162\u6027\u7279\u5B9A\u75BE\u60A3\u306B\u6307\u5B9A\u3055\u308C\u3066\u3044\u308B\u3002"@ja . . . . . . . . . . . "Dr-Peter-Radtke-Schauspieler-in-Kafkas-Bericht-fuer-eine-Akademie-Copyright-Foto-Monica-Boirar-aka-Monica-Beurer.jpg"@en . . "\u041D\u0435\u0441\u043E\u0432\u0435\u0440\u0448\u0435\u043D\u043D\u044B\u0439 \u043E\u0441\u0442\u0435\u043E\u0433\u0435\u043D\u0435\u0437"@ru . . . . . "Tip of a Fassier\u2013Duval intramedullary rod manufactured by Pega Medical.png"@en . . . "y"@en . . . . . . . . "1674"@en . "Galar d\u00FAchasach creatlaigh ina dtarla\u00EDonn foirmi\u00FA easnamhach na gcn\u00E1mh is na bhf\u00EDoch\u00E1in taca\u00EDochta ionas go mb\u00EDonn an creatlach an-bhriosc sobhriste. M\u00E1 bh\u00EDonn an neamhord an-dian, is f\u00E9idir go bhfulaingeoidh na\u00EDon\u00E1n an iliomad brist\u00ED diana cn\u00E1imhe is go bhfaighidh b\u00E1s ina leanbh. Muna mb\u00EDonn s\u00E9 r\u00F3dhian, is f\u00E9idir go mairfidh s\u00E9 go mbeidh s\u00E9 f\u00E1sta ach go bhfulaingeoidh briseadh cn\u00E1imhe \u00F3 am go ch\u00E9ile, sna g\u00E9aga \u00EDochtaracha go h\u00E1irithe. Uaireanta, tarla\u00EDonn crand\u00FA is dath\u00FA gorm ar scl\u00E9ara\u00ED na s\u00FAl do na p\u00E1ist\u00ED seo."@ga . . . . . . . . . . . . . . "Dr. Willem Vrolik coined the term \"osteogenesis imperfecta\" in 1849."@en . "\u0391\u03C4\u03B5\u03BB\u03AE\u03C2 \u03BF\u03C3\u03C4\u03B5\u03BF\u03B3\u03AD\u03BD\u03B5\u03C3\u03B7"@el . . . . "Osteogenesis imperfecta"@in . . . . . . . . . . . . . . . . "La osteog\u00E9nesis imperfecta u osteogenia imperfecta (tambi\u00E9n llamada enfermedad de los huesos de cristal) es un trastorno cong\u00E9nito, es decir, presente al nacer, que se caracteriza por una fragilidad de hueso excesiva, como consecuencia de una deficiencia cong\u00E9nita en la elaboraci\u00F3n de una prote\u00EDna, el col\u00E1geno tipo I. Quienes portan el defecto tienen menos col\u00E1geno de lo normal o es de una menor calidad y como es una prote\u00EDna importante en la estructura de los huesos, causa una fragilidad y debilidad poco usual de los huesos.\u200B El diagn\u00F3stico es radiol\u00F3gico, incluso antes del parto.\u200B\u200B"@es . . . . "horizontal"@en . . . . . . . . . . . . . "Birth"@en . . . . . . . . . "\u9AA8\u5F62\u6210\u4E0D\u5168\u75C7\uFF08\u3053\u3064\u3051\u3044\u305B\u3044\u3075\u305C\u3093\u3057\u3087\u3046\u3001OI: Osteogenesis Imperfecta\uFF09\u306F\u3001\u6613\u9AA8\u6298\u6027\u30FB\u9032\u884C\u6027\u306E\u9AA8\u5909\u5F62\u306A\u3069\u306E\u9AA8\u8106\u5F31\u6027\u3092\u793A\u3059\u75C5\u72B6\u306B\u52A0\u3048\u3001\u69D8\u3005\u306A\u7A0B\u5EA6\u306E\u7D50\u5408\u7D44\u7E54\u306E\u75C5\u72B6\u3092\u793A\u3059\u5148\u5929\u6027\u306E\u75BE\u60A3\u3067\u3042\u308B\u3002\u5C0F\u5150\u6162\u6027\u7279\u5B9A\u75BE\u60A3\u306B\u6307\u5B9A\u3055\u308C\u3066\u3044\u308B\u3002"@ja . . . . . . . . . . . . . . . . "Ost\u00E9ogen\u00E8se imparfaite"@fr . . . "\u6210\u9AA8\u4E0D\u5168\u75C7\uFF08osteogenesis imperfecta\uFF09\uFF0C\u7C21\u7A31OI\uFF0C\u53C8\u7A31\u8106\u9AA8\u75C7\uFF0C\u662F\u4E00\u7A2E\u4E3B\u8981\u5F71\u97FF\u9AA8\u9ABC\u7684\u907A\u50B3\u6027\u75BE\u75C5\u3002\u5B83\u5C0E\u81F4\u9AA8\u9ABC\u5BB9\u6613\u9AA8\u6298\u3002\u56B4\u91CD\u7A0B\u5EA6\u53EF\u80FD\u5F9E\u8F15\u5FAE\u81F3\u56B4\u91CD\u3002\u5176\u4ED6\u75C7\u72C0\u53EF\u80FD\u5305\u62EC\u85CD\u978F\u819C\uFF0C\u8EAB\u6750\u77ED\u5C0F\uFF0C\uFF0C\u807D\u529B\u53D7\u640D\uFF0C\u547C\u5438\u554F\u984C\u548C\u7259\u9F52\u554F\u984C\u3002\u82E5\u662F\u56B4\u91CD\u7684\u6210\u9AA8\u4E0D\u5168\u75C7\uFF0C\u53EF\u80FD\u8F15\u5FAE\u7684\u78B0\u649E\u5C31\u6703\u9020\u6210\u56B4\u91CD\u7684\u9AA8\u6298\uFF0C\u56E0\u6B64\u9019\u985E\u7684\u75C5\u60A3\u88AB\u7A31\u70BA\u300C\u73BB\u7483\u5A03\u5A03\u300D\u6216\u300C\u73BB\u7483\u9AA8\u300D\u3002 \u6839\u672C\u7684\u6A5F\u8F49\u901A\u5E38\u6E90\u81EA\u7D50\u7DE0\u7D44\u7E54\uFF0D\u7F3A\u4E4F\u3002\u5728\u8D85\u904E90\uFF05\u7684\u75C5\u4F8B\u4E2D\u662F\u7531\u65BC\u6216\u57FA\u56E0\u7684\u7A81\u8B8A\u3002\u9019\u4E9B\u907A\u50B3\u554F\u984C\u901A\u5E38\u4EE5\u9AD4\u67D3\u8272\u9AD4\u986F\u6027\u907A\u50B3\u7684\u65B9\u5F0F\u6216\u7D93\u7531\u65B0\u7684\u7A81\u8B8A\u767C\u751F\u3002\u81F3\u5C11\u6709\u516B\u7A2E\u985E\u578B\uFF0C\u5176\u4E2DI\u578B\u6700\u4E0D\u56B4\u91CD\uFF0CII\u578B\u6700\u56B4\u91CD\u3002\u901A\u5E38\u7D93\u7531\u5176\u75C7\u72C0\u78BA\u8A3A\uFF0C\u4E26\u53EF\u901A\u904E\u81A0\u539F\u86CB\u767D\u6AA2\u6E2C\u6216DNA\u6AA2\u6E2C\u78BA\u8A8D\u3002 \u6210\u9AA8\u4E0D\u5168\u75C7\u76EE\u524D\u6C92\u6709\u6CBB\u7652\u65B9\u6CD5\u3002\u85C9\u7531\u904B\u52D5\u4F86\u7DAD\u6301\u5065\u5EB7\u7684\u751F\u6D3B\u5F62\u614B\u53CA\u907F\u514D\u5438\u83F8\u6709\u52A9\u65BC\u9810\u9632\u9AA8\u6298\u3002\u6CBB\u7642\u53EF\u80FD\u5305\u62EC\u9AA8\u6298\u7167\u8B77\uFF0C\u6B62\u75DB\u85E5\uFF0C\u7269\u7406\u6CBB\u7642\uFF0C\u652F\u67B6\u6216\u8F2A\u6905\u4EE5\u53CA\u624B\u8853\u3002\u4E00\u7A2E\u5C07\u91D1\u5C6C\u68D2\u7A7F\u904E\u9577\u9AA8\u7684\u624B\u8853\u53EF\u80FD\u53EF\u4EE5\u5F37\u5316\u9577\u9AA8\u3002\u76EE\u524D\u8A66\u9A57\u6027\u7684\u8B49\u64DA\u652F\u6301\u4F7F\u7528\u985E\u85E5\u7269\u3002 \u5927\u7D0415,000\u4EBA\u4E2D\u6703\u51FA\u73FE\u4E00\u4F8B\u6210\u9AA8\u4E0D\u5168\u75C7\u7684\u75C5\u4F8B\u3002\u7D50\u679C\u53D6\u6C7A\u65BC\u75BE\u75C5\u7684\u985E\u578B\uFF0C\u5927\u591A\u6578\u4EBA\u9810\u5F8C\u4E0D\u932F\u3002\u81EA\u53E4\u4EE5\u4F86\u5C31\u63CF\u8FF0\u4E86\u9019\u7A2E\u60C5\u6CC1\uFF0C\u8853\u8A9E\u300C\u6210\u9AA8\u4E0D\u5168\u75C7\u300D\u65BC1895\u5E74\u958B\u59CB\u4F7F\u7528\uFF0C\u610F\u5473\u8457\u7D50\u69CB\u767C\u80B2\u4E0D\u5B8C\u5168\u7684\u9AA8\u9ABC\u3002\u3002"@zh . . . . . "1112043666"^^ . . . . . . . . . . . . . . "\u062A\u0643\u0648\u0646 \u0627\u0644\u0639\u0638\u0645 \u0627\u0644\u0646\u0627\u0642\u0635"@ar . . . . . . . . . . . . . . "Osteogenesis_imperfecta_X-ray__of_right_femur.png"@en . . . . . . . . . "Spine, chest, and pelvis"@en . . . . . . . . . . . . . . . "9342" . . . . . . . . . "X-rays of three people with OI type V: a newborn, a child, and an adult. Evident are somewhat deformed long bones with widened metaphyses."@en . . "Osteog\u00E9nese imperfeita (portugu\u00EAs europeu) ou Osteog\u00EAnese imperfeita (portugu\u00EAs brasileiro), osteogenesis imperfecta ou doen\u00E7a de Ekman-Lobstein (do latim, osteo- osso; -genesis forma\u00E7\u00E3o; imperfecta, imperfeita) ou Ossos de vidro \u00E9 um grupo de doen\u00E7as gen\u00E9ticas raras caracterizadas por ossos e dentes fr\u00E1geis. A severidade da doen\u00E7a depende dos genes afetados. Existem 9 tipos identificados dessa doen\u00E7a. As formas severa e moderada da doen\u00E7a podem ser diagnosticadas logo no nascimento, ou mesmo antes do nascimento, e s\u00E3o encontradas em cerca de 5 por 100.000 rec\u00E9m-nascidos."@pt . . "Osteogenesis imperfecta"@sv . . . . . "\uACE8\uD615\uC131\uBD80\uC804\uC99D"@ko . . . "Osteogenesis imperfecta"@cs . "Osteogenesis imperfecta (OI), atau dikenal juga dengan sebutan penyakit tulang rapuh, merupakan kelompok kelainan genetik yang secara khusus memengaruhi kondisi tulang manusia. Penyakit ini dapat menyebabkan tulang sangat mudah patah, dan tingkat keparahan bisa dalam stadium rendah dengan risiko rendah hingga stadium tinggi dengan risiko paling berat. Gejala lain yang bisa terjadi ialah adanya semburat biru pada bagian putih mata, tinggi badan yang pendek, , mengalami , terjadi masalah pada pernapasan, dan juga dapat menimbulkan masalah dengan gigi. Gejala komplikasi juga bisa terjadi yakni dan juga diseksi aorta."@in . . . "L\u2019ost\u00E9ogen\u00E8se imparfaite, appel\u00E9e aussi \u00AB maladie des os de verre \u00BB, est un groupe de maladies caract\u00E9ris\u00E9es par une fragilit\u00E9 osseuse excessive, due \u00E0 un d\u00E9faut cong\u00E9nital d\u2019\u00E9laboration des fibres collag\u00E8nes du tissu conjonctif qui forme la trame de l\u2019os. Tous les types se caract\u00E9risent par une extr\u00EAme fragilit\u00E9 des os, signe le plus typique de la maladie. Cependant, tous les tissus contenant du collag\u00E8ne sont aussi touch\u00E9s (os, peau, tendon). La plupart du temps cette maladie est due \u00E0 une mutation g\u00E9n\u00E9tique spontan\u00E9e de novo mais elle peut aussi \u00EAtre familiale et transmise par seulement l\u2019un des deux parents (transmission autosomique dominante). Il existe 6 types d\u2019ost\u00E9ogen\u00E8se imparfaite. Cause de la fragilit\u00E9 des os, le collag\u00E8ne, qui compose 25 % de la matrice osseuse (le reste est compos\u00E9 surtout de calcium et de phosphore), est soit synth\u00E9tis\u00E9 en moindre quantit\u00E9 (type 1) ou bien il s'agit d'un collag\u00E8ne anormal qui est synth\u00E9tis\u00E9 (les autres types). Le tissu osseux devient alors plus fragile. La matrice osseuse est synth\u00E9tis\u00E9e par des cellules appel\u00E9es \u00AB ost\u00E9oblastes \u00BB. Le collag\u00E8ne est aussi pr\u00E9sent dans la peau, les ligaments, la scl\u00E9rotique de l\u2019\u0153il (blanc de l\u2019\u0153il) et la dentine ce qui donne des manifestations cliniques tr\u00E8s vari\u00E9es. Ces manifestations peuvent aller d\u2019une simple coloration bleue de la scl\u00E9rotique jusqu\u2019\u00E0 une forme l\u00E9tale \u00E0 la naissance en passant par des formes s\u00E9v\u00E8res entrainant un handicap profond chez la personne atteinte. La cons\u00E9quence la plus connue de l'ost\u00E9ogen\u00E8se imparfaite est la survenue de fractures multiples sans traumatisme majeur. Chez certaines personnes (type III, IVB) les dents deviennent translucides et fragiles. Des troubles de l\u2019audition (otospongiose) sont aussi possibles. Et la plupart du temps, la personne atteinte est de tr\u00E8s petite taille. Une vie constamment \u00E9maill\u00E9e d\u2019hospitalisations et de r\u00E9\u00E9ducation."@fr . "Osteogenesis imperfecta (OI, n\u011Bkdy naz\u00FDv\u00E1no nemoc k\u0159ehk\u00FDch kost\u00ED) je genetick\u00E1 kostn\u00ED porucha. Lid\u00E9 s OI se rod\u00ED s defektn\u00ED pojivovou tk\u00E1n\u00ED, nebo bez schopnosti ji vytvo\u0159it, obvykle kv\u016Fli nedostatku kolagenu typu I."@cs . "Osteogenesis_imperfecta_X-ray__of_left_forearm.png"@en . . . . . . . . . . . . "Blue sclerae, as in the eyes of the girl above, are a classic non-pathognomonic sign of OI."@en . . "XrayOITypeV-Audult.jpg"@en . "Nicolas Malebranche.jpg"@en . . . . . . . . . . . "Osteogenesis imperfecta (Abk\u00FCrzung OI; altgriechisch \u1F40\u03C3\u03C4\u03AD\u03BF\u03BD ost\u00E9on, deutsch \u201AKnochen\u2018, \u03B3\u03AD\u03BD\u03B5\u03C3\u03B9\u03C2 g\u00E9nesis, deutsch \u201AEntstehung\u2018 und lateinisch imperfecta \u201Aunvollkommen\u2018) wird umgangssprachlich auch als Glasknochenkrankheit bezeichnet, da die Knochen leicht zerbrechlich sind und im R\u00F6ntgenbild eine glasige Struktur aufweisen. Die OI ist eine seltene Erbkrankheit, f\u00FCr die \u00FCberwiegend autosomal-dominante, seltener auch autosomal-rezessive Erbg\u00E4nge beschrieben sind. Hauptmerkmal der OI ist das ver\u00E4nderte Kollagen vom Typ I, was zu einer abnorm hohen Knochenbr\u00FCchigkeit mit unterschiedlichen Krankheitsbildern f\u00FChrt."@de . "Theresia Haidlmayr.jpg"@en . . . . . . . "Q78.0" . . . . . . . "Medikuntzan, osteogenesi inperfektua edo kristalezko hezurren gaitza, I motako kolagenoaren jaiotzetiko gutxiegitasunak eragindako asaldura kongenitoa da. Hezurren gehiegizko hauskortasunagatik ezaugarritzen da eta arazo hau pairatzen dutenek, behar baino kolageno gutxiago edo kalitate gutxiko kolagenoa izan ohi dute. Gurasoengandik heredatu edo mutazio berri baten ondorioz sor daiteke. Oso erraz bereizten da erradiologikoki, hain zuzen ere, jaio baino lehen bereizi ahal da."@eu . . . . . . . . . . . . . "Osteog\u00E9nesis imperfecta"@es . . . . . . . "Osteogenesi imperfetta"@it . . . . "First appearance in print of \u00ABosteogenesis imperfecta\u00BB .jpg"@en . "\u6210\u9AA8\u4E0D\u5168\u75C7\uFF08osteogenesis imperfecta\uFF09\uFF0C\u7C21\u7A31OI\uFF0C\u53C8\u7A31\u8106\u9AA8\u75C7\uFF0C\u662F\u4E00\u7A2E\u4E3B\u8981\u5F71\u97FF\u9AA8\u9ABC\u7684\u907A\u50B3\u6027\u75BE\u75C5\u3002\u5B83\u5C0E\u81F4\u9AA8\u9ABC\u5BB9\u6613\u9AA8\u6298\u3002\u56B4\u91CD\u7A0B\u5EA6\u53EF\u80FD\u5F9E\u8F15\u5FAE\u81F3\u56B4\u91CD\u3002\u5176\u4ED6\u75C7\u72C0\u53EF\u80FD\u5305\u62EC\u85CD\u978F\u819C\uFF0C\u8EAB\u6750\u77ED\u5C0F\uFF0C\uFF0C\u807D\u529B\u53D7\u640D\uFF0C\u547C\u5438\u554F\u984C\u548C\u7259\u9F52\u554F\u984C\u3002\u82E5\u662F\u56B4\u91CD\u7684\u6210\u9AA8\u4E0D\u5168\u75C7\uFF0C\u53EF\u80FD\u8F15\u5FAE\u7684\u78B0\u649E\u5C31\u6703\u9020\u6210\u56B4\u91CD\u7684\u9AA8\u6298\uFF0C\u56E0\u6B64\u9019\u985E\u7684\u75C5\u60A3\u88AB\u7A31\u70BA\u300C\u73BB\u7483\u5A03\u5A03\u300D\u6216\u300C\u73BB\u7483\u9AA8\u300D\u3002 \u6839\u672C\u7684\u6A5F\u8F49\u901A\u5E38\u6E90\u81EA\u7D50\u7DE0\u7D44\u7E54\uFF0D\u7F3A\u4E4F\u3002\u5728\u8D85\u904E90\uFF05\u7684\u75C5\u4F8B\u4E2D\u662F\u7531\u65BC\u6216\u57FA\u56E0\u7684\u7A81\u8B8A\u3002\u9019\u4E9B\u907A\u50B3\u554F\u984C\u901A\u5E38\u4EE5\u9AD4\u67D3\u8272\u9AD4\u986F\u6027\u907A\u50B3\u7684\u65B9\u5F0F\u6216\u7D93\u7531\u65B0\u7684\u7A81\u8B8A\u767C\u751F\u3002\u81F3\u5C11\u6709\u516B\u7A2E\u985E\u578B\uFF0C\u5176\u4E2DI\u578B\u6700\u4E0D\u56B4\u91CD\uFF0CII\u578B\u6700\u56B4\u91CD\u3002\u901A\u5E38\u7D93\u7531\u5176\u75C7\u72C0\u78BA\u8A3A\uFF0C\u4E26\u53EF\u901A\u904E\u81A0\u539F\u86CB\u767D\u6AA2\u6E2C\u6216DNA\u6AA2\u6E2C\u78BA\u8A8D\u3002 \u6210\u9AA8\u4E0D\u5168\u75C7\u76EE\u524D\u6C92\u6709\u6CBB\u7652\u65B9\u6CD5\u3002\u85C9\u7531\u904B\u52D5\u4F86\u7DAD\u6301\u5065\u5EB7\u7684\u751F\u6D3B\u5F62\u614B\u53CA\u907F\u514D\u5438\u83F8\u6709\u52A9\u65BC\u9810\u9632\u9AA8\u6298\u3002\u6CBB\u7642\u53EF\u80FD\u5305\u62EC\u9AA8\u6298\u7167\u8B77\uFF0C\u6B62\u75DB\u85E5\uFF0C\u7269\u7406\u6CBB\u7642\uFF0C\u652F\u67B6\u6216\u8F2A\u6905\u4EE5\u53CA\u624B\u8853\u3002\u4E00\u7A2E\u5C07\u91D1\u5C6C\u68D2\u7A7F\u904E\u9577\u9AA8\u7684\u624B\u8853\u53EF\u80FD\u53EF\u4EE5\u5F37\u5316\u9577\u9AA8\u3002\u76EE\u524D\u8A66\u9A57\u6027\u7684\u8B49\u64DA\u652F\u6301\u4F7F\u7528\u985E\u85E5\u7269\u3002 \u5927\u7D0415,000\u4EBA\u4E2D\u6703\u51FA\u73FE\u4E00\u4F8B\u6210\u9AA8\u4E0D\u5168\u75C7\u7684\u75C5\u4F8B\u3002\u7D50\u679C\u53D6\u6C7A\u65BC\u75BE\u75C5\u7684\u985E\u578B\uFF0C\u5927\u591A\u6578\u4EBA\u9810\u5F8C\u4E0D\u932F\u3002\u81EA\u53E4\u4EE5\u4F86\u5C31\u63CF\u8FF0\u4E86\u9019\u7A2E\u60C5\u6CC1\uFF0C\u8853\u8A9E\u300C\u6210\u9AA8\u4E0D\u5168\u75C7\u300D\u65BC1895\u5E74\u958B\u59CB\u4F7F\u7528\uFF0C\u610F\u5473\u8457\u7D50\u69CB\u767C\u80B2\u4E0D\u5B8C\u5168\u7684\u9AA8\u9ABC\u3002\u3002"@zh . . . . . . . . . . "Left forearm"@en . . . . . . . "Siondr\u00F3m cn\u00E1mh briosc"@ga . "ped"@en . . . . "Two postoperative radiographs of a patient who underwent rodding surgery for osteogenesis imperfecta.png"@en . "Long term"@en . . . . . "Osteogenesis imperfecta"@en . . "Osteogenesis imperfecta (OI) \u00E4r en genetisk sjukdom som beror p\u00E5 en mutation i genen f\u00F6r kollagen. Sjukdomen \u00E4r \u00E4rftlig och inneb\u00E4r framf\u00F6rallt olika grader av bensk\u00F6rhet. De som drabbas av de sv\u00E5rare formerna d\u00F6r i sp\u00E4dbarnsstadiet medan de lindrigast drabbade lever ett helt normalt liv, med n\u00E5got fler benbrott \u00E4n andra. Det inneb\u00E4r att inom sjukdomen finns allt fr\u00E5n sv\u00E5rt handikappade till fullt arbetsf\u00F6ra personer. De flesta besv\u00E4ras dock av n\u00E5gon form av v\u00E4rk oavsett form av sjukdomen."@sv . "400"^^ . "Medikuntzan, osteogenesi inperfektua edo kristalezko hezurren gaitza, I motako kolagenoaren jaiotzetiko gutxiegitasunak eragindako asaldura kongenitoa da. Hezurren gehiegizko hauskortasunagatik ezaugarritzen da eta arazo hau pairatzen dutenek, behar baino kolageno gutxiago edo kalitate gutxiko kolagenoa izan ohi dute. Gurasoengandik heredatu edo mutazio berri baten ondorioz sor daiteke. Oso erraz bereizten da erradiologikoki, hain zuzen ere, jaio baino lehen bereizi ahal da. Gaixotasun hau gaixotasun arraro bat da. Munduko %0,008 bakarrik jasaten du (0,5 milioi pertsona gutxi gorabehera, Espainian 2.700 pertsona inguru)."@eu . . "756.51" . . . . . . . . . . . "Genetic"@en . . . . . . "Excerpts from [[#"@en . . . . . "9342"^^ . . . . . "500"^^ . . . . "Jordanne Whiley Rio2016 cr.jpg"@en . . . . "Where Vrolik would describe what is now type II OI, in 1833 Dr. Jean Lobstein was the first to describe what is now called type I OI."@en . . . . . . . . . . . "Osteog\u00E8nesi imperfecta"@ca . . . . "1"^^ . "2"^^ . "3"^^ . . . "300"^^ . . . . . . . "Depends on the type"@en . . . . . . . . . . . . . "313"^^ . . . .