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dbr:Odorant-binding_protein
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Odorant-binding protein Odorant binding protein
rdfs:comment
Le Odorant binding proteins (OBP) o proteine leganti gli odori sono piccole proteine solubili abbondanti nel secreto del muco nasale di molte specie animali e sono presenti in alta concentrazione (circa 10 mM) anche nella linfa sensillare dei chemosensoriali degli insetti. Queste proteine sono state inizialmente identificate in base alla loro capacità di legarsi con moderata affinità con degli odoranti radioattivi. Inizialmente le Odorant binding proteins sono state descritte come trasportatori (carriers) delle molecole olfattive attraverso la mucosa nasale che ricopre l'epitelio olfattivo. Le molecole olfattive sono infatti generalmente di natura idrofobica e la mucosa nasale è uno strato acquoso che ricopre l'epitelio olfattivo. Negli ultimi due decenni vi è stata una intensa ricerca su Odorant-binding proteins (OBPs) are small (10 to 30 kDa) soluble proteins secreted by auxiliary cells surrounding olfactory receptor neurons, including the nasal mucus of many vertebrate species and in the sensillar lymph of chemosensory sensilla of insects. OBPs are characterized by a specific protein domain that comprises six α-helices joined by three disulfide bonds. Although the function of the OBPs as a whole is not well established, it is believed that they act as odorant transporters, delivering the odorant molecules to olfactory receptors in the cell membrane of sensory neurons.
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Le Odorant binding proteins (OBP) o proteine leganti gli odori sono piccole proteine solubili abbondanti nel secreto del muco nasale di molte specie animali e sono presenti in alta concentrazione (circa 10 mM) anche nella linfa sensillare dei chemosensoriali degli insetti. Queste proteine sono state inizialmente identificate in base alla loro capacità di legarsi con moderata affinità con degli odoranti radioattivi. Inizialmente le Odorant binding proteins sono state descritte come trasportatori (carriers) delle molecole olfattive attraverso la mucosa nasale che ricopre l'epitelio olfattivo. Le molecole olfattive sono infatti generalmente di natura idrofobica e la mucosa nasale è uno strato acquoso che ricopre l'epitelio olfattivo. Negli ultimi due decenni vi è stata una intensa ricerca sulla funzione presunta di queste proteine, tuttavia, il ruolo fisiologico preciso di queste proteine ancora rimane sconosciuto. Odorant-binding proteins (OBPs) are small (10 to 30 kDa) soluble proteins secreted by auxiliary cells surrounding olfactory receptor neurons, including the nasal mucus of many vertebrate species and in the sensillar lymph of chemosensory sensilla of insects. OBPs are characterized by a specific protein domain that comprises six α-helices joined by three disulfide bonds. Although the function of the OBPs as a whole is not well established, it is believed that they act as odorant transporters, delivering the odorant molecules to olfactory receptors in the cell membrane of sensory neurons. The olfactory receptors of terrestrial animals exist in an aqueous environment, yet detect odorants that are primarily hydrophobic. The aqueous solubility of hydrophobic odorants is greatly enhanced via odorant-binding proteins, which exist in the extracellular fluid surrounding the odorant receptors. This family is composed of pheromone binding proteins (PBP), which are male-specific and associate with pheromone-sensitive neurons and general-odorant-binding proteins (GOBP). These proteins were initially identified on the basis of their ability to bind with moderate-affinity radioactively labeled odorants.
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