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      "http://www.w3.org/2000/01/rdf-schema#comment": "Lebofloxazinoa hirugarren belaunaldiko kinolonen familiako antibiotikoa da. Ofloxazinoaren enantiomero aktibo bat da, potentziaren ia bikoitza duena, toxikotasunarekin edo gabe. Beste kinolona batzuk bezala, DNA paketatzeaz arduratzen den entzima inhibitzen du. Bakterio gram-negatiboen aurka egiten du, familia horretako antibiotiko gehienek bezala, bai eta bakterio gram-positiboen aurka ere. Beraz, espektro zabaleko antibiotiko a da.", 
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      "http://dbpedia.org/ontology/abstract": "Η λεβοφλοξασίνη, που πωλείται με την επωνυμία Levaquin μεταξύ άλλων, είναι αντιβιοτικό φάρμακο. Χρησιμοποιείται για τη θεραπεία ενός αριθμού βακτηριακών λοιμώξεων όπως οξεία βακτηριακή ιγμορίτιδα, πνευμονία, λοίμωξη από H. pylori (σε συνδυασμό με άλλα φάρμακα), λοιμώξεις του ουροποιητικού συστήματος, και ορισμένοι τύποι γαστρεντερίτιδας. Μαζί με άλλα αντιβιοτικά μπορεί να χρησιμοποιηθεί για τη θεραπεία της φυματίωσης, της μηνιγγίτιδας ή της φλεγμονώδους νόσου της πυέλου. Η χρήση συνιστάται γενικά μόνο όταν δεν είναι διαθέσιμες άλλες επιλογές. Διατίθεται από το στόμα, ενδοφλεβίως και σε μορφή οφθαλμικής σταγόνας. Συχνές ανεπιθύμητες ενέργειες περιλαμβάνουν ναυτία, διάρροια και προβλήματα ύπνου. Σοβαρές ανεπιθύμητες ενέργειες μπορεί να περιλαμβάνουν ρήξη τένοντα, , επιληπτικές κρίσεις, ψύχωση και ενδεχομένως μόνιμη . Η βλάβη του τένοντα μπορεί να εμφανιστεί μήνες μετά την ολοκλήρωση της θεραπείας. Οι άνθρωποι μπορεί επίσης να υποστούν πιο εύκολα ηλιακό έγκαυμα. Σε άτομα με σοβαρή μυασθένεια, η μυϊκή αδυναμία και τα προβλήματα αναπνοής μπορεί να επιδεινωθούν. Αν και δεν συνιστάται η χρήση κατά τη διάρκεια της εγκυμοσύνης, ο κίνδυνος φαίνεται να είναι χαμηλός. Η χρήση άλλων φαρμάκων σε αυτήν την τάξη φαίνεται να είναι ασφαλής κατά το θηλασμό. Ωστόσο, η ασφάλεια της λεβοφλοξασίνης είναι ασαφής. Η λεβοφλοξασίνη είναι αντιβιοτικό ευρέος φάσματος της κατηγορίας φαρμάκων φθοροκινολόνης. Συνήθως οδηγεί σε θάνατο των βακτηρίων. Είναι το αριστερό ισομερές της φαρμακευτικής αγωγής της οφλοξασίνης. Η λεβοφλοξασίνη κατοχυρώθηκε με δίπλωμα ευρεσιτεχνίας το 1985 και εγκρίθηκε για ιατρική χρήση στις Ηνωμένες Πολιτείες το 1996. Συμπεριλαμβάνεται στον κατάλογο βασικών φαρμάκων του Παγκόσμιου Οργανισμού Υγείας. Διατίθεται ως γενόσημο φάρμακο. Το 2017, ήταν το 165ο πιο συχνά συνταγογραφούμενο φάρμακο στις Ηνωμένες Πολιτείες, με περισσότερες από 3 εκατομμύρια συνταγές.", 
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      "http://www.w3.org/2000/01/rdf-schema#comment": "Levofloxacin ist ein antibiotisch wirksamer Arzneistoff. Chemisch handelt es sich um ein Fluorchinolon der dritten Generation. Levofloxacin kam 1993 in Japan und 1998 in Deutschland auf den Markt, in den USA wurde es 1996 durch die FDA zugelassen. Die FDA informierte 2008 und 2013 über neu beobachtete schwere Nebenwirkungen bei systemisch angewendeten Fluorchinolon und ordnete entsprechende Maßnahmen an. 2015 hat sie nach ärztlichen Meldeberichten das Nutzen-Risiko-Verhältnis von Cipro-, Levo-, Moxi- und Ofloxacin neu bewertet und 2016 die Anwendung deutlich eingeschränkt. Auch in EU-Ländern wurden mehrmals Warnhinweise und Anwendungsbeschränkungen für Fluorchinolone verfügt. Die Europäische Arzneimittelagentur hat die schwerwiegenden, potentiell dauerhaften und Lebensqualität beeinträchti", 
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      "http://dbpedia.org/property/wikiPageUsesTemplate": { "__deferred": { "uri": "http://dbpedia.org/resource/Template:Drugbankcite" } }, 
      "http://dbpedia.org/ontology/abstract": "レボフロキサシン (Levofloxacin, LVFX) は、ニューキノロン系の合成抗菌薬(抗生物質ではない) 。日本の第一三共によって発明され、先発薬品名はクラビット。 様々な細菌感染症に適応があり、急性細菌性副鼻腔炎、肺炎、尿路感染症、慢性前立腺炎、ある種の胃腸炎に使用される。また他の抗生物質と併用し、結核、髄膜炎、骨盤腹膜炎の治療にも使用される。投与ルートは、経口、静注、点眼剤で利用可能。 1996年にアメリカ合衆国で医療承認された。名前の由来は「英語: CRAVE(熱望する、切望する)IT」から CRAVIT とし、待ち望まれた薬剤であることを表現した。現在はWHO必須医薬品モデル・リストに収録され、後発医薬品も利用可能である。", 
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      "http://dbpedia.org/ontology/abstract": "Левофлоксаци́н — лекарственное средство, антибактериальный препарат, входящий в группу фторхинолонов ІІІ поколения. Он используется для лечения ряда бактериальных инфекций, включая острый бактериальный синусит, пневмонию, H. pylori (в сочетании с другими лекарствами), инфекции мочевыводящих путей, хронический простатит и некоторые типы гастроэнтерита. Наряду с другими антибиотиками его можно использовать для лечения туберкулеза, менингита или воспалительных заболеваний органов малого таза. Обычно рекомендуется использовать только тогда, когда другие параметры недоступны. Он доступен для приема внутрь, внутривенно и в форме глазных капель. Общие побочные эффекты включают тошноту, диарею и проблемы со сном. Серьезные побочные эффекты могут включать разрыв сухожилия, воспаление сухожилий, судороги, психоз и потенциально необратимое повреждение периферических нервов. Повреждение сухожилий может появиться через несколько месяцев после завершения лечения. Люди также могут легко получить солнечный ожог. У людей с миастенией могут усиливаться мышечная слабость и проблемы с дыханием. Хотя использование во время беременности не рекомендуется, риск представляется низким. Использование других препаратов этого класса во время грудного вскармливания представляется безопасным; Однако безопасность левофлоксацина неясна. Представляет собой L-энантиомер офлоксацина с антибактериальной активностью вдвое большей, чем у офлоксацина, являющегося рацемической смесью L- и D- энантиомеров.", 
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      "http://www.w3.org/2000/01/rdf-schema#comment": "Lévofloxacine est la dénomination commune internationale d'un antibiotique de la famille des fluoroquinolones, commercialisé en Europe par Sanofi-Aventis avec le nom de marque Tavanic. Cet antibiotique est employé pour traiter les sinusites bactériennes aiguës, les pneumonies aiguës, les infections urinaires, les (en) et certains types de gastro-entérites. En association avec d'autres antibiotiques, la lévofloxacine peut être utilisée pour le traitement de la tuberculose, la méningite et de maladie inflammatoire pelvienne. Ce médicament est administré par voie orale, voie intraveineuse et sous forme de gouttes oculaires.", 
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      "http://www.w3.org/2000/01/rdf-schema#comment": "레보플록사신(levofloxacin, 판매 상표명: Levaquin 등)은 항생물질의 하나이다. 부비강염, 폐렴, 요로감염증, , 일부 종류의 장염 등 수많은 병균 감염을 치료하기 위해 사용된다. 다른 항생물질들과 마찬가지로 결핵, 수막염, 골반염 치료에 사용할 수 있다. 구강, 정맥 주사, 안약 형태의 제품으로 구매할 수 있다. 일반적인 부작용으로는 구역질, 설사, 수면 장애가 포함된다. 심각한 부작용으로는 , 건염, 뇌전증 발작, 정신증, 잠재적으로 영구적인 말초신경손상이 포함될 수 있다. 치료가 끝난 이후 수개월 간 건손상이 발생할 수 있다. 사람들은 또한 을 입을 수 있다. 중증 근무력증 환자의 경우 근육 약화와 호흡 문제가 악화될 수 있다. 임신 중 복용은 위험성이 낮아 보이지만 권장되지는 않는다. 이 계열의 다른 약물의 복용은 모유 수유 중에 안전한 것으로 간주되지만, 레보플록사신의 안전은 불명확하다. 레보플록사신은 계 이다. 보통 살균 효과가 있다. 약물 의 이다.", 
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      "http://dbpedia.org/ontology/abstract": "Levofloxacin (varunamn: Tavanic, Oftaquix) är ett antibiotikum tillhörande klassen fluorokinoloner. Det används vid infektioner i bihålor, urinvägar (inklusive njurar och urinblåsa), prostata, hud- och mjukdelar samt vid lunginflammation hos personer med kronisk bronkit.Levofloxacin kan också användas för att förebygga infektion med mjältbrandsbakterier (anthrax) då man exponerats för detta, eller för att behandla en existerande mjältbrandsinfektion.", 
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      "http://dbpedia.org/ontology/abstract": "Lewofloksacyna (łac. levofloxacinum) – wielofunkcyjny organiczny związek chemiczny, chemioterapeutyk z grupy chinolonów, enancjomer S ofloksacyny, stosowany w leczeniu zakażeń bakteryjnych, profilaktyki po zabiegu leczenia operacyjnego zaćmy oraz . Zaleca się aby podczas leczenia lewofloksacyną oraz 2 dni po jego zakończeniu unikać kąpieli słonecznych oraz solarium.", 
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      "http://www.w3.org/2000/01/rdf-schema#comment": "Levofloxacine is een antibioticum uit de groep van fluorchinolonen. Het wordt verkocht onder verschillende merknamen, zoals Levaquin en Tavanic. Levofloxacine is een synthetisch antibacterieel middel dat wordt gebruikt voor het behandelen van ernstige en levensbedreigende bacteriële infecties. Het is een zogenaamd reservemiddel, dat enkel wordt gebruikt als meer reguliere middelen onvoldoende blijken te werken. De voorloper van levofloxacine, ofloxacine, was een racemaat. Onderzoek leidde tot de ontdekking van de meer actieve L-vorm, waarna levofloxacine werd ontwikkeld.", 
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      "http://dbpedia.org/ontology/abstract": "레보플록사신(levofloxacin, 판매 상표명: Levaquin 등)은 항생물질의 하나이다. 부비강염, 폐렴, 요로감염증, , 일부 종류의 장염 등 수많은 병균 감염을 치료하기 위해 사용된다. 다른 항생물질들과 마찬가지로 결핵, 수막염, 골반염 치료에 사용할 수 있다. 구강, 정맥 주사, 안약 형태의 제품으로 구매할 수 있다. 일반적인 부작용으로는 구역질, 설사, 수면 장애가 포함된다. 심각한 부작용으로는 , 건염, 뇌전증 발작, 정신증, 잠재적으로 영구적인 말초신경손상이 포함될 수 있다. 치료가 끝난 이후 수개월 간 건손상이 발생할 수 있다. 사람들은 또한 을 입을 수 있다. 중증 근무력증 환자의 경우 근육 약화와 호흡 문제가 악화될 수 있다. 임신 중 복용은 위험성이 낮아 보이지만 권장되지는 않는다. 이 계열의 다른 약물의 복용은 모유 수유 중에 안전한 것으로 간주되지만, 레보플록사신의 안전은 불명확하다. 레보플록사신은 계 이다. 보통 살균 효과가 있다. 약물 의 이다. 레보플록사신은 1985년 특허를 받았으며 1996년 미국에서 의학용으로 승인되었다. 의료제도에 필수적인 가장 효과적이고 안전한 의약품 목록인 WHO 필수 의약품 목록에 등재되어 있다. 제네릭 의약품으로 구매가 가능하다. 개발도상국의 도매가는 치료 주 단위로 대략 US$0.44–0.95이다. 미국의 주 단위 치료 비용은 대략 $50–100이다. 2016년 미국에서 300만 건 이상의 처방과 함께 161번째로 많이 처방을 받은 약물이었다.", 
      "http://dbpedia.org/property/excretion": "Kidney, mostly unchanged", 
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      "http://dbpedia.org/ontology/abstract": "Levofloxacin, sold under the brand name Levaquin among others, is an antibiotic medication. It is used to treat a number of bacterial infections including acute bacterial sinusitis, pneumonia, H. pylori (in combination with other medications), urinary tract infections, chronic prostatitis, and some types of gastroenteritis. Along with other antibiotics it may be used to treat tuberculosis, meningitis, or pelvic inflammatory disease. Use is generally recommended only when other options are not available. It is available by mouth, intravenously, and in eye drop form. Common side effects include nausea, diarrhea, and trouble sleeping. Serious side effects may include tendon rupture, tendon inflammation, seizures, psychosis, and potentially permanent peripheral nerve damage. Tendon damage may appear months after treatment is completed. People may also sunburn more easily. In people with myasthenia gravis, muscle weakness and breathing problems may worsen. While use during pregnancy is not recommended, risk appears to be low. The use of other medications in this class appear to be safe while breastfeeding; however, the safety of levofloxacin is unclear. Levofloxacin is a broad-spectrum antibiotic of the fluoroquinolone drug class. It usually results in death of the bacteria. It is the left-handed isomer of the medication ofloxacin. Levofloxacin was patented in 1985 and approved for medical use in the United States in 1996. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication. In 2020, it was the 240th most commonly prescribed medication in the United States, with more than 1 million prescriptions.", 
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      "http://dbpedia.org/ontology/abstract": "Levofloxacin ist ein antibiotisch wirksamer Arzneistoff. Chemisch handelt es sich um ein Fluorchinolon der dritten Generation. Levofloxacin kam 1993 in Japan und 1998 in Deutschland auf den Markt, in den USA wurde es 1996 durch die FDA zugelassen. Die FDA informierte 2008 und 2013 über neu beobachtete schwere Nebenwirkungen bei systemisch angewendeten Fluorchinolon und ordnete entsprechende Maßnahmen an. 2015 hat sie nach ärztlichen Meldeberichten das Nutzen-Risiko-Verhältnis von Cipro-, Levo-, Moxi- und Ofloxacin neu bewertet und 2016 die Anwendung deutlich eingeschränkt. Auch in EU-Ländern wurden mehrmals Warnhinweise und Anwendungsbeschränkungen für Fluorchinolone verfügt. Die Europäische Arzneimittelagentur hat die schwerwiegenden, potentiell dauerhaften und Lebensqualität beeinträchtigenden Nebenwirkungen zuletzt 2018 neu bewertet und Anwendungseinschränkungen empfohlen. Das Bundesinstitut für Arzneimittel und Medizinprodukte hat daraufhin am 8. April 2019 in einem umfassenden Bescheid die Indikationen für Fluorchinolone weiter eingeschränkt und eine weitere Aktualisierung der Gebrauchs- und Fachinformationen angeordnet um auf möglicherweise irreversible Nebenwirkungen hinzuweisen. Ärzte wurden über einen Rote-Hand-Brief am 8. April 2019 informiert, Fluorchinolone bei einfachen Infektionen nicht mehr einzusetzen.", 
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