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        "http://dbpedia.org/ontology/abstract" : [ "Immunomodulatory imide drugs (IMiDs) are a class of immunomodulatory drugs (drugs that adjust immune responses) containing an imide group. The IMiD class includes thalidomide and its analogues (lenalidomide, pomalidomide, and . These drugs may also be referred to as 'Cereblon modulators'. Cereblon (CRBN) is the protein targeted by this class of drugs. The name \"IMiD\" alludes to both \"IMD\" for \"immunomodulatory drug\" and the forms imide, imido-, imid-, and imid. The development of analogs of thalidomide was precipitated by the discovery of the anti-angiogenic and anti-inflammatory properties of the drug yielding a new way of fighting cancer as well as some inflammatory diseases after it had been banned in 1961. The problems with thalidomide included; teratogenic side effects, high incidence of other adverse reactions, poor solubility in water and poor absorption from the intestines. In 1998 thalidomide was approved by the U.S. Food and Drug Administration (FDA) for use in newly diagnosed multiple myeloma (MM) under strict regulations. This has led to the development of a number of analogs with fewer side effects and increased potency which include lenalidomide and pomalidomide, which are currently marketed and manufactured by Celgene.",
          "الأدوية الإيميدية المعدلة للمناعة (بالإنجليزية: Immunomodulatory imide drugs)، رمزها «آي إم آي دي»، فئة من معدلات المناعة (أدوية تعدل الاستجابة المناعية) تحوي مجموعة إيميد. تشمل هذه الفئة الثاليدوميد ونظائره (الليناليدوميد والبوماليدوميد والإيبيردوميد). قد يُطلق على هذه العوامل «معدلات السيريبلون»، وهو بروتين تستهدفه هذه الأدوية. يشير الرمز «آي إم آي دي» إلى كل من «دواء معدل مناعي» و«الصيغة الإيميدية». تسارع تطوير نظائر الثاليدوميد بعد اكتشاف خصائصه الدوائية المثبطة للتكون الوعائي والمضادة للالتهاب، وهذا كشف طريقةً جديدةً لمكافحة السرطان وبعض الأمراض الالتهابية بعد حظر استخدامه عام 1961. ترافق استخدام الثاليدوميد مع عدد من الاضطرابات الصحية مثل التأثيرات الجانبية الماسخة وارتفاع معدل وقوع التفاعلات العكسية الأخرى وضعف الانحلال في الماء وسوء الامتصاص من الأمعاء. في عام 1998، وافقت إدارة الغذاء والدواء الأمريكية على استخدام الدواء في علاج الورم النخاعي المتعدد المشخص حديثًا تحت قواعد صارمة. قاد هذا إلى تطوير عدد من النظائر التي تترافق مع آثار جانبية أقل وفعالية أعلى شملت الليناليدوميد والبوماليدوميد اللذين دخلا الأسواق حاليًا من تصنيع شركة سلجين." ] ,
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