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  • directly regulates
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  • Process(P1) directly regulates process(P2) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2.
  • p directly regulates q iff p is immediately causally upstream of q and p regulates q.
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  • directly regulates (processual)
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