About: COVID-19 patients upregulate toll-like receptor 4-mediated inflammatory signaling that mimics bacterial sepsis

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About: COVID-19 patients upregulate toll-like receptor 4-mediated inflammatory signaling that mimics bacterial sepsis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	COVID-19 patients upregulate toll-like receptor 4-mediated inflammatory signaling that mimics bacterial sepsis
Creator	Kim, Yeon-Sook Jo, Eun-Kyeong Cheon, Shinhyea Kim, Young Sohn, Kyung Kim, Hyeon Kim, In Jeong, Hyeongseok Lee, Jooyeon Lee, Sung-Gwon Park, Chungoo Silwal, Prashanta
Source	BioRxiv
abstract	Observational studies of the ongoing coronavirus disease 2019 (COVID-19) outbreak suggest that a cytokine storm is involved in the pathogenesis of severe illness. However, the molecular mechanisms underlying the altered pathological inflammation in COVID-19 are largely unknown. We report here that toll-like receptor (TLR) 4-mediated inflammatory signaling molecules are upregulated in peripheral blood mononuclear cells (PBMCs) from COVID-19 patients, compared with healthy controls. Among the most highly increased inflammatory mediators in severe/critically ill patients, S100A9, an alarmin and TLR4 ligand, was found as a noteworthy biomarker, because it inversely correlated with the serum albumin levels. These data support a link between TLR4 signaling and pathological inflammation during COVID-19 and contribute to develop therapeutic approaches through targeting TLR4-mediated inflammation.
has issue date	2020-07-17(xsd:dateTime)
bibo:doi	10.1101/2020.07.17.207878
has license	biorxiv
sha1sum (hex)	ffbddfa5ea17d89045392354611cac8905bc1194
schema:url	https://doi.org/10.1101/2020.07.17.207878
resource representing a document's title	COVID-19 patients upregulate toll-like receptor 4-mediated inflammatory signaling that mimics bacterial sepsis
schema:publication	bioRxiv
resource representing a document's body	covid:ffbddfa5ea17d89045392354611cac8905bc1194#body_text
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