About: Lineages, Sub-Lineages and Variants of Enterovirus 68 in Recent Outbreaks

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Lineages, Sub-Lineages and Variants of Enterovirus 68 in Recent Outbreaks
Creator	Tong, Aarons, Emma Bible, Jon Cheuk, Y Halligan, Eugene Lauinger, Ina Macmahon, Eithne
Source	Medline; PMC
abstract	Enterovirus 68 (EV68) was first isolated in 1962. Very few cases of EV68 infection were described over the ensuing 40 years. However, in the past few years, an increase in severe respiratory tract infections associated with EV68 has been reported. We identified two clusters of EV68 infection in South London, UK, one each in the autumn/winters of 2009 and 2010. Sequence comparison showed significant homology of the UK strains with those from other countries including the Netherlands, Japan and the Philippines, which reported EV68 outbreaks between 2008 and 2010. Phylogenetic analysis of all available VP1 sequences indicated the presence of two modern EV68 lineages. The 2010 UK strains belonged to lineage 2. Lineage 1 could be further divided into two sub-lineages: some Japanese and Dutch strains collected between 2004 and 2010 form a distinct sub-lineages (sub-lineage 1.1), whereas other strains from the UK, Japan, Netherlands and Philippines collected between 2008 and 2010 represent sub-lineage 1.2. The UK 2009 strains together with several Dutch and Japanese strains from 2009/2010 represents one variant (1.2.1), whereas those from the Philippines a second variant (1.2.2). Based on specific deletions and substitutions, we suggest rules for the assignment of lineages and sub-lineages. Molecular epidemiological analysis indicates rapid recent evolution of EV68 and this may explain the recent findings of a global resurgence of EV68. Continuous global monitoring of the clinical and molecular epidemiology of EV68 is recommended.
has issue date	2012-04-20(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0036005
bibo:pmid	22536453
has license	cc-by
sha1sum (hex)	ff6c239b90248fc655555af1ebe9f856791afb9d
schema:url	https://doi.org/10.1371/journal.pone.0036005
resource representing a document's title	Lineages, Sub-Lineages and Variants of Enterovirus 68 in Recent Outbreaks
has PubMed Central identifier	PMC3335014
has PubMed identifier	22536453
schema:publication	PLoS One
resource representing a document's body	covid:ff6c239b90248fc655555af1ebe9f856791afb9d#body_text
is schema:about of	named entity 'lineage 2' named entity '2010' named entity '2010' named entity 'Philippines' named entity 'CLUSTERS' named entity 'GLOBAL' named entity 'RESURGENCE' named entity 'SIGNIFICANT' named entity 'SUGGEST' named entity '1.1' named entity 'DISTINCT' named entity 'NETHERLANDS' named entity '1962' named entity 'EVOLUTION' named entity 'COULD BE' named entity 'AVAILABLE' named entity 'MONITORING' named entity 'collected' named entity '2010' named entity 'Phylogenetic analysis' named entity '2012' named entity '2009' named entity 'PLoS ONE' named entity 'VP1' named entity 'deletions' named entity 'molecular epidemiology' named entity 'Dutch' named entity 'Bible' named entity 'Dutch' named entity 'Enterovirus 68' named entity 'respiratory tract infections' named entity 'South London' named entity 'Enterovirus 68' named entity 'Qiagen' named entity 'respiratory tract infections' named entity 'protein' named entity 'enteroviruses' named entity '2, 7' named entity 'Invitrogen' named entity 'retrospective study' named entity 'EV68' named entity 'EV68' named entity 'enterovirus' named entity 'Netherlands' named entity 'respiratory tract' named entity 'recombination' named entity 'enterovirus' named entity 'homology' named entity 'Nucleotide' named entity 'enterovirus' named entity 'host immunity' named entity 'Finland' named entity 'GenBank' named entity '85%' named entity 'reporting bias' named entity 'EV68' named entity 'Rhinovirus' named entity 'molecular evolution' named entity 'nucleotide sequence' named entity 'Amino acid' named entity 'EV68' named entity 'phylogenetic analysis' named entity 'antigenic' named entity 'EV68' named entity 'Phylogenetic trees' named entity 'EV68' named entity 'EV68' named entity 'EV68' named entity 'enteroviruses' named entity 'sequence data' named entity 'recombination' named entity 'RNA virus' named entity 'Applied Biosystems' named entity 'enterovirus' named entity 'EV68'

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