About: Human H-ferritin presenting RBM of spike glycoprotein as potential vaccine of SARS-CoV-2

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About: Human H-ferritin presenting RBM of spike glycoprotein as potential vaccine of SARS-CoV-2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Human H-ferritin presenting RBM of spike glycoprotein as potential vaccine of SARS-CoV-2
Creator	Liu, Yan Wang, Chuang Ding, Hui Cheng, Jianwei Ding, Fengjiao Ke, Tianyi Lao, Fang Ouyang, Fangxing Wang, Xiaofei Xi, Lun Yan, Xichong Yao, Dehui Zhang, Rongkun Zhang, Zeyi
Source	BioRxiv
abstract	The outbreak of COVID-19 has so far inflicted millions of people all around the world and will have a long lasting effect on every aspect of everyone’s life. Yet there is no effective approved treatment for the disease. In an effort of utilizing human ferritin as nanoplatform for drug delivery, we engineered a fusion protein by presenting receptor-binding motif (RBM) of SARS-CoV-2 virus spike glycoprotein on the N-terminus of ferritin subunits. The designed fusion protein with a cage-like structure, similar to that of corona virus, is a potential anti-SARS-CoV-2 vaccine. We hereby show the construction, preparation, and characterization of the fusion protein RBM-HFtn. Our initial affinity study confirmed its biological activity towards ACE2 receptor which suggests its mode of action against SARS-CoV-2 could be either through vaccine therapy or blocking the cellular entry of virus as antagonist of ACE2 receptor.
has issue date	2020-06-08(xsd:dateTime)
bibo:doi	10.1101/2020.05.25.115618
has license	biorxiv
sha1sum (hex)	ff4e9c2e98b87f2a1c4837824b29079774cba73d
schema:url	https://doi.org/10.1101/2020.05.25.115618
resource representing a document's title	Human H-ferritin presenting RBM of spike glycoprotein as potential vaccine of SARS-CoV-2
schema:publication	bioRxiv
resource representing a document's body	covid:ff4e9c2e98b87f2a1c4837824b29079774cba73d#body_text
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