About: Isotype-specific antibody responses to bovine herpesvirus 1 in sera and mucosal secretions of calves after experimental reinfection and after reactivation

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About: Isotype-specific antibody responses to bovine herpesvirus 1 in sera and mucosal secretions of calves after experimental reinfection and after reactivation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Isotype-specific antibody responses to bovine herpesvirus 1 in sera and mucosal secretions of calves after experimental reinfection and after reactivation
Creator	Madic', J Magdalena2, J Quak, J Van Oirschot, J-T
Source	Elsevier; Medline; PMC
abstract	Abstract Isotype-specific antibody responses to bovine herpesvirus 1 (BHV1) were measured in sera, nasal, ocular and genital secretions of calves that were reinfected with BHV1 and 6 weeks later treated with corticosteroids to reactivate putative latent virus. After reinfection and after reactivation, no BHV1-specific IgM antibody response was detected. The serum IgA response was only transiently detectable after reinfection and again appeared rapidly after reactivation in most calves. Most calves showed an increase in nasal and ocular IgA titres after reinfection and reactivation; some calves also had IgA antibodies in genital secretions. A salient finding was that after reinfection and reactivation more calves showed a serum IgA response than virus shedding or an increase in serum IgG1 or IgG2 titres. This suggests that the serum IgA response would be the most sensitive indicator to detect BHV1 reinfection and reactivation. No correlation was found between nasal IgA titre at the time of reinfection or corticosteroid treatment and the period of virus shedding, suggesting that nasal IgA does not play a major role in protection against reinfection with BHV1.
has issue date	1995-07-31(xsd:dateTime)
bibo:doi	10.1016/0165-2427(94)05379-7
bibo:pmid	8533302
has license	els-covid
sha1sum (hex)	feabae1996bb1c5ea202cf1e25fc955b31f3a921
schema:url	https://doi.org/10.1016/0165-2427%2894%2905379-7
resource representing a document's title	Isotype-specific antibody responses to bovine herpesvirus 1 in sera and mucosal secretions of calves after experimental reinfection and after reactivation
has PubMed Central identifier	PMC7119823
has PubMed identifier	8533302
schema:publication	Veterinary Immunology and Immunopathology
resource representing a document's body	covid:feabae1996bb1c5ea202cf1e25fc955b31f3a921#body_text
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