About: Problems in physiological experimental animal models investigated with factorial design

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Problems in physiological experimental animal models investigated with factorial design
Creator	Br^nstad, Aurora Eide, Dag Gjerde, Eli-Anne Reed, Rolf
Source	Elsevier; Medline; PMC
abstract	Abstract In the present study we investigated four variables using factorial design to decide if any of these could explain the variations in the control measurements of interstitial fluid pressure (P if) in rat trachea that were experienced. This approach requires only a fraction of the animals normally needed when studying each factor separately. P if in tracheal tissue was measured with the servocontrolled counterpressure system using sharpened micropipettes. The measurements were performed over a period of 60min and are presented as mean for every 15min period. The factors investigated in the study were: three strains of female rats (Strain) two brands of diets (Food); two breeder companies (Source); and finally two batches of the same set of animals to repeat the experiment twice (Week), using a total of 48 animals. There was a highly significant effect within Strain the first week (p=0.007), but this response was not observed the second week. The interaction between Strain×Week was significant (p=0.007) while the main effects Strain or Week alone were not significant. The response pattern for Strain and Food was inconsistent for the two experimental weeks studied. These experiments made it possible for us to simultaneously test several factors and exclude these factors as the reason for the observed changes in our experiments since the experiments did not allow the conclusion that one or several of these factors could explain the variation in P if.
has issue date	2004-04-30(xsd:dateTime)
bibo:doi	10.1016/j.jeas.2004.01.002
bibo:pmid	32288297
has license	els-covid
sha1sum (hex)	fe6f4b67c2bc40f3b14baa25a0bf9e64f05d1ee2
schema:url	https://doi.org/10.1016/j.jeas.2004.01.002
resource representing a document's title	Problems in physiological experimental animal models investigated with factorial design
has PubMed Central identifier	PMC7134602
has PubMed identifier	32288297
schema:publication	Journal of Experimental Animal Science
resource representing a document's body	covid:fe6f4b67c2bc40f3b14baa25a0bf9e64f05d1ee2#body_text
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