About: Glycogen synthase kinase (GSK)-3 and the double-strand RNA-dependent kinase, PKR: When two kinases for the common good turn bad()

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About: Glycogen synthase kinase (GSK)-3 and the double-strand RNA-dependent kinase, PKR: When two kinases for the common good turn bad() Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Glycogen synthase kinase (GSK)-3 and the double-strand RNA-dependent kinase, PKR: When two kinases for the common good turn bad()
Creator	Bavelloni, Alberto Blalock, William Faenza, Irene Piazzi, Manuela
source	Elsevier; Medline; PMC
abstract	Glycogen synthase kinase (GSK)-3α/β and the double-stranded RNA-dependent kinase PKR are two sentinel kinases that carry-out multiple similar yet distinct functions in both the cytosol and the nucleus. While these kinases belong to separate signal transduction cascades, they demonstrate an uncanny propensity to regulate many of the same proteins either through direct phosphorylation or by altering transcription/translation, including: c-MYC, NF-κB, p53 and TAU, as well as each another. A significant number of studies centered on the GSK3 kinases have led to the identification of the GSK3 interactome and a number of substrates, which link GSK3 activity to metabolic control, translation, RNA splicing, ribosome biogenesis, cellular division, DNA repair and stress/inflammatory signaling. Interestingly, many of these same pathways and processes are controlled by PKR, but unlike the GSK3 kinases, a clear picture of proteins interacting with PKR and a complete listing of its substrates is still missing. In this review, we take a detailed look at what is known about the PKR and GSK3 kinases, how these kinases interact to influence common cellular processes (innate immunity, alternative splicing, translation, glucose metabolism) and how aberrant activation of these kinases leads to diseases such as Alzheimer's disease (AD), diabetes mellitus (DM) and cancer.
has issue date	2020-06-05(xsd:dateTime)
bibo:doi	10.1016/j.bbamcr.2020.118769
bibo:pmid	32512016
has license	no-cc
sha1sum (hex)	fe627e8022097b69a48140e799516064b4390c57
schema:url	https://doi.org/10.1016/j.bbamcr.2020.118769
resource representing a document's title	Glycogen synthase kinase (GSK)-3 and the double-strand RNA-dependent kinase, PKR: When two kinases for the common good turn bad()
has PubMed Central identifier	PMC7273171
has PubMed identifier	32512016
schema:publication	Biochim Biophys Acta Mol Cell Res
resource representing a document's body	covid:fe627e8022097b69a48140e799516064b4390c57#body_text
is schema:about of	named entity 'GSK' named entity 'kinases' named entity 'double-strand' named entity 'common good' named entity 'DYRK2' named entity 'apoptosis' named entity 'isoforms' named entity 'energy expenditure' named entity 'kinase' named entity 'p53' named entity 'translation initiation' named entity 'eIF4E' named entity 'TAU' named entity 'ADAR1' named entity 'adenosine deaminase' named entity 'viruses' named entity 'c-MYC' named entity 'GSK3β' named entity 'MYC' named entity 'GSK3' named entity 'C/EBPα' named entity 'proteosome' named entity 'C/EBPα' named entity 'lipids' named entity 'start codon' named entity 'mRNA splicing' named entity 'cell cycle arrest' named entity 'AKT' named entity 'GSK' named entity 'insulin' named entity 'renal cancer' named entity 'precursor proteins' named entity 'signal transducer and activator of transcription' named entity 'alternatively spliced' named entity 'ADAR' named entity 'transcription factors' named entity 'gene' named entity 'p65' named entity 'kinase' named entity 'wild-type' named entity 'translation initiation' named entity 'GSK3β' named entity 'eIF4E' named entity 'GSK3β' named entity 'Creutzfeldt-Jakob disease' named entity 'GSK3β' named entity 'miRNA' named entity 'innate immune' named entity 'inflammatory response' named entity 'binding domains' named entity 'kinase' named entity 'HIV' named entity 'S18' named entity 'upstream open reading frames' named entity 'enzyme' named entity 'RNAase' named entity 'cell proliferation' named entity 'transactivation domain' named entity 'AKT' named entity 'GCN2' named entity 'phosphorylation' named entity 'eIF2B' named entity 'ROS' named entity 'phosphorylation' named entity 'DHX9' named entity 'protein kinase domain' named entity 'MYC' named entity 'transcription factors' named entity 'caspase-9' named entity 'cell cycle' named entity 'isoform' named entity 'nucleus' named entity 'osteoclastogenesis' named entity 'SCF' named entity 'reactive oxygen species' named entity 'TNFα' named entity 'guanine' named entity 'GSK3'

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