About: Early respiratory viral infections in infants with cystic fibrosis

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About: Early respiratory viral infections in infants with cystic fibrosis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Early respiratory viral infections in infants with cystic fibrosis
Creator	Ferkol, Thomas Gebregziabher, Netsanet Ranganathan, Sarath Stick, Stephen Storch, Gregory Davis, Stephanie Slaven, James Deschamp, Ashley Hall, Graham Hatch, Joseph
topic	covid:fde8ec984e9fab26dbb6c3f55318ca2f695b298f#this
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: Viral infections contribute to morbidity in cystic fibrosis (CF), but the impact of respiratory viruses on the development of airway disease is poorly understood. METHODS: Infants with CF identified by newborn screening were enrolled prior to 4 months of age to participate in a prospective observational study at 4 centers. Clinical data were collected at clinic visits and weekly phone calls. Multiplex PCR assays were performed on nasopharyngeal swabs to detect respiratory viruses during routine visits and when symptomatic. Participants underwent bronchoscopy with bronchoalveolar lavage (BAL) and a subset underwent pulmonary function testing. We present findings through 8.5 months of life. RESULTS: Seventy infants were enrolled, mean age 3.1 ± 0.8 months. Rhinovirus was the most prevalent virus (66%), followed by parainfluenza (19%), and coronavirus (16%). Participants had a median of 1.5 viral positive swabs (range 0–10). Past viral infection was associated with elevated neutrophil concentrations and bacterial isolates in BAL fluid, including recovery of classic CF bacterial pathogens. When antibiotics were prescribed for respiratory-related indications, viruses were identified in 52% of those instances. CONCLUSIONS: Early viral infections were associated with greater neutrophilic inflammation and bacterial pathogens. Early viral infections appear to contribute to initiation of lower airway inflammation in infants with CF. Antibiotics were commonly prescribed in the setting of a viral infection. Future investigations examining longitudinal relationships between viral infections, airway microbiome, and antibiotic use will allow us to elucidate the interplay between these factors in young children with CF.
has issue date	2019-02-27(xsd:dateTime)
bibo:doi	10.1016/j.jcf.2019.02.004
bibo:pmid	30826285
has license	no-cc
sha1sum (hex)	fde8ec984e9fab26dbb6c3f55318ca2f695b298f
schema:url	https://doi.org/10.1016/j.jcf.2019.02.004
resource representing a document's title	Early respiratory viral infections in infants with cystic fibrosis
has PubMed Central identifier	PMC6711838
has PubMed identifier	30826285
schema:publication	J Cyst Fibros
resource representing a document's body	covid:fde8ec984e9fab26dbb6c3f55318ca2f695b298f#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/fde8ec984e9fab26dbb6c3f55318ca2f695b298f
is schema:about of	named entity 'Past' named entity 'infants' named entity 'disease' named entity 'swabs' named entity 'development' named entity 'prevalent' named entity 'CYSTIC FIBROSIS' named entity 'AGE' named entity 'FOLLOWED BY' named entity 'CORONAVIRUS' named entity 'POORLY' named entity 'RESPIRATORY VIRUSES' named entity 'COLLECTED' named entity 'UNDERSTOOD' named entity 'CLINIC' named entity 'ASSOCIATED WITH' named entity 'ALLOW' named entity 'INFANTS' covid:arg/fde8ec984e9fab26dbb6c3f55318ca2f695b298f named entity 'INFANTS' named entity 'ROUTINE' named entity 'FLUID' named entity 'LIFE' named entity 'ENROLLED' named entity 'EARLY' named entity 'FINDINGS' named entity 'MORBIDITY' named entity 'IDENTIFIED' named entity 'CYSTIC FIBROSIS' named entity 'SWABS' named entity '10%' named entity 'BRONCHOSCOPY WITH BRONCHOALVEOLAR LAVAGE' named entity 'PARTICIPANTS' named entity 'RESPIRATORY' named entity 'PRESCRIBED' named entity 'MEDIAN' named entity 'POSITIVE' named entity '1.5' named entity 'PRIOR TO' named entity 'BAL' named entity 'BACKGROUND' named entity 'RELATED' named entity 'ISOLATES' named entity 'THESE' named entity 'INCLUDING' named entity 'VIRAL INFECTIONS' named entity 'EARLY' named entity 'APPEAR' named entity 'NEUTROPHILIC INFLAMMATION' named entity 'INITIATION' named entity 'FUTURE' named entity 'SYMPTOMATIC' named entity 'PROSPECTIVE OBSERVATIONAL STUDY' named entity 'PERFORMED' named entity 'RELATIONSHIPS' named entity 'INVESTIGATIONS' named entity '8.5' named entity 'CLASSIC' named entity 'PREVALENT' named entity 'EXAMINING' named entity 'NEWBORN SCREENING' named entity 'TO DETECT' named entity 'VIRAL INFECTION' named entity 'AIRWAY INFLAMMATION' named entity 'ANTIBIOTICS' named entity 'RESULTS' named entity 'SEVENTY' named entity '3.1' named entity 'PHONE CALLS' named entity 'YOUNG CHILDREN'

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