About: Epidemic and molecular evolution of human bocavirus in hospitalized children with acute respiratory tract infection

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About: Epidemic and molecular evolution of human bocavirus in hospitalized children with acute respiratory tract infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Epidemic and molecular evolution of human bocavirus in hospitalized children with acute respiratory tract infection
Creator	Cao, W.-C Liu, W Zhao, J Zhang, X.-A Zhang, Y.-Y Huang, D.-D Liu, E.-M Lu, Q.-B Wang, H.-Y Wo, Y
Source	Medline; PMC
abstract	Human bocavirus (HBoV) is a novel parvovirus, often associated with respiratory tract diseases in children. This study explored the epidemiological characteristics and molecular evolution of HBoV-1 in southeastern China. Nasopharyngeal aspirates were collected from children admitted to hospital with acute respiratory tract infections. HBoV-1 was detected using real-time reverse transcription polymerase chain reaction and further characterized by complete genome sequences analysis. Among the 3,022 recruited children, 386 (12.77 %) were HBoV-1-positive and 300 (77.72 %) had co-detection with other respiratory viruses. Seasonal prevalence peaked in summer. HBoV-1 presence was significantly associated with asthma attack [odds ratio = 1.74; 95 % confidence interval: 1.30, 2.31; p < 0.001]. Similar results were obtained when either single detection or co-detection of HBoV-1 was considered, demonstrating the minor impact of co-detection on the clinical characteristics or epidemic pattern. Phylogenetic analysis based on the complete genome sequences showed that all the HBoV-1 sequences clustered together and no branch was formed that was supported by bootstrap value ≥750. The overall evolutionary rate of the complete genome of HBoV-1 was estimated at 1.08 × 10(−4) nucleotide substitutions per site per year (s/s/y) [95 % highest probability density: (0.40–1.86) × 10(−4) s/s/y]. Selective pressure analysis showed that all the ω-values were less than 1, suggesting that HBoV-1 was under negative selective pressure. Site-by-site analysis identified the codon site 40 of the VP1 gene under positive selection. In conclusion, our study disclosed the epidemiological and genetic dynamics of HBoV-1 epidemics in southeastern China in the most recent 3 years, the information of which might help to further improve our understanding of HBoV-1 infection and guide better surveillance and control strategies in the future. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10096-014-2215-7) contains supplementary material, which is available to authorized users.
has issue date	2014-07-29(xsd:dateTime)
bibo:doi	10.1007/s10096-014-2215-7
bibo:pmid	25070494
has license	no-cc
sha1sum (hex)	fdb56218f255f344baa49d58cd68f50286971d7d
schema:url	https://doi.org/10.1007/s10096-014-2215-7
resource representing a document's title	Epidemic and molecular evolution of human bocavirus in hospitalized children with acute respiratory tract infection
has PubMed Central identifier	PMC7087953
has PubMed identifier	25070494
schema:publication	Eur J Clin Microbiol Infect Dis
resource representing a document's body	covid:fdb56218f255f344baa49d58cd68f50286971d7d#body_text
is schema:about of	named entity 'molecular evolution' named entity 'attack' named entity 'confidence interval' named entity 'infection' named entity 'CHINA' named entity 'PATTERN' named entity 'ASTHMA ATTACK' named entity 'MOLECULAR EVOLUTION' named entity 'PEAKED' named entity 'STUDY' named entity 'IMPACT' named entity 'USING' named entity 'impact' named entity 'reverse transcription polymerase chain reaction' named entity 'analysis' named entity 'demonstrating' named entity 'asthma' named entity 'respiratory tract infections' named entity 'peaked' named entity 'HBoV' named entity 'molecular evolution' named entity 'epidemic' named entity 'reverse transcription polymerase chain reaction' named entity 'respiratory tract infection' named entity 'molecular evolution' named entity 'p-value' named entity 'infection' named entity 'SLAC' named entity 'HBoV' named entity 'Chongqing Medical University' named entity 'chronic medical conditions' named entity 'North Carolina State University' named entity 'causal relationship' named entity 'gene' named entity 'severe pneumonia' named entity 'pneumonia' named entity 'codon' named entity 'Selective pressure' named entity 'N-terminus' named entity 'data set' named entity 'VP1' named entity 'viral infection' named entity 'HBoV' named entity 'BIC' named entity 'HBoV' named entity 'carnivore' named entity 'pathogens' named entity 'nasopharyngeal' named entity 'PLA2' named entity 'Viruses' named entity 'morbidity' named entity 'epidemiological data' named entity 'SAS' named entity 'PLA2' named entity 'recombinant' named entity 'respiratory symptoms' named entity 'laboratory tests' named entity 'parvoviruses' named entity 'selective pressure' named entity 'pathogen' named entity 'sPLA2' named entity 'posterior probability' named entity 'genus' named entity 'recombination' named entity 'Parvoviridae' named entity 'epidemiology' named entity 'respiratory syncytial virus' named entity 'asthma' named entity 'wheezing' named entity 'evolutionary history' named entity 'amino-terminal' named entity 'Invitrogen'

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