About: Infants hospitalized for Bordetella pertussis infection commonly have respiratory viral coinfections

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About: Infants hospitalized for Bordetella pertussis infection commonly have respiratory viral coinfections Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Infants hospitalized for Bordetella pertussis infection commonly have respiratory viral coinfections
Creator	Midulla, F Carsetti, R Concato, C Frassanito, A Nenna, R Nicolai, A Pierangeli, A Schiavoni, I Stefanelli, P Tozzi, A
Source	Medline; PMC
abstract	BACKGROUND: Whether viral coinfections cause more severe disease than Bordetella pertussis (B. pertussis) alone remains unclear. We compared clinical disease severity and sought clinical and demographic differences between infants with B. pertussis infection alone and those with respiratory viral coinfections. We also analyzed how respiratory infections were distributed during the 2 years study. METHODS: We enrolled 53 infants with pertussis younger than 180 days (median age 58 days, range 17–109 days, 64.1% boys), hospitalized in the Pediatric Departments at “Sapienza” University Rome and Bambino Gesù Children’s Hospital from August 2012 to November 2014. We tested in naso-pharyngeal washings B. pertussis and 14 respiratory viruses with real-time reverse-transcriptase-polymerase chain reaction. Clinical data were obtained from hospital records and demographic characteristics collected using a structured questionnaire. RESULTS: 28/53 infants had B. pertussis alone and 25 viral coinfection: 10 human rhinovirus (9 alone and 1 in coinfection with parainfluenza virus), 3 human coronavirus, 2 respiratory syncytial virus. No differences were observed in clinical disease severity between infants with B. pertussis infection alone and those with coinfections. Infants with B. pertussis alone were younger than infants with coinfections, and less often breastfeed at admission. CONCLUSIONS: In this descriptive study, no associations between clinical severity and pertussis with or without co-infections were found. TRIAL REGISTRATION: Policlinico Umberto I: protocol 213/14, 3085/13.02.2014, retrospectively registered. Bambino Gesù Children’s Hospital: protocol n. RF-2010-2317709.
has issue date	2017-07-12(xsd:dateTime)
bibo:doi	10.1186/s12879-017-2567-6
bibo:pmid	28701160
has license	cc-by
sha1sum (hex)	fd6a5e41d7c2ffcd1079e540927707456897b6a8
schema:url	https://doi.org/10.1186/s12879-017-2567-6
resource representing a document's title	Infants hospitalized for Bordetella pertussis infection commonly have respiratory viral coinfections
has PubMed Central identifier	PMC5506634
has PubMed identifier	28701160
schema:publication	BMC Infect Dis
resource representing a document's body	covid:fd6a5e41d7c2ffcd1079e540927707456897b6a8#body_text
is schema:about of	named entity 'B. pertussis' named entity 'HOSPITALIZED' named entity 'INFANTS' named entity 'CAUSE' named entity 'BACKGROUND' named entity 'UNCLEAR' named entity 'RESPIRATORY' named entity 'SEVERE DISEASE' named entity 'INFANTS' named entity 'INFECTION' named entity 'DISTRIBUTED' named entity 'STUDY' covid:arg/fd6a5e41d7c2ffcd1079e540927707456897b6a8 named entity 'CLINICAL' named entity 'VIRAL' named entity 'RESPIRATORY INFECTIONS' named entity 'VIRAL' named entity 'RESPIRATORY' named entity 'DISEASE SEVERITY' named entity 'BORDETELLA PERTUSSIS' named entity 'HAVE' named entity 'YEARS' named entity 'COMPARED' named entity 'HOW' named entity 'ANALYZED' named entity 'BORDETELLA PERTUSSIS INFECTION' named entity 'PERTUSSIS' named entity 'DEMOGRAPHIC' named entity 'distributed' named entity 'remains' named entity 'Bordetella pertussis' named entity 'coinfections' named entity 'coinfections' named entity 'asymptomatic' named entity 'Bordetella pertussis' named entity 'parainfluenza virus' named entity 'adenovirus' named entity 'nasopharyngeal aspirate' named entity 'Mannheim' named entity 'virus' named entity 'mucus' named entity 'coinfection' named entity 'bronchiolitis' named entity 'Real-Time PCR' named entity 'pertussis' named entity 'bronchiolitis' named entity 'coinfection' named entity 'hypertension' named entity 'birth weight' named entity 'coinfections' named entity 'infection' named entity 'coinfection' named entity 'infection' named entity 'respiratory syncytial virus' named entity 'influenza virus' named entity 'defibrinated' named entity 'breastfeeding' named entity 'immunological' named entity 'B. pertussis' named entity 'RT-PCR' named entity 'metapneumovirus' named entity 'respiratory rate' named entity 'pertussis' named entity 'Bordetella pertussis' named entity 'B. pertussis' named entity 'anemia' named entity 'Mann-Whitney' named entity 'B. pertussis' named entity 'B. pertussis' named entity 'B. pertussis' named entity 'respiratory rate' named entity 'clinical disease'

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