About: Identification of CD8(+ )cytotoxic T lymphocyte epitopes from porcine reproductive and respiratory syndrome virus matrix protein in BALB/c mice

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About: Identification of CD8(+ )cytotoxic T lymphocyte epitopes from porcine reproductive and respiratory syndrome virus matrix protein in BALB/c mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification of CD8(+ )cytotoxic T lymphocyte epitopes from porcine reproductive and respiratory syndrome virus matrix protein in BALB/c mice
Creator	Tong, Guangzhi Zhang, Weijun Bu, Zhigao Wang, Qun Wu, Donglai Lin, Yan Yang, Tao Bai, Yu Liu, Guangliang Liu, Nihong Tong, Tiegang Xiao, Yihong
Source	PMC
abstract	Twenty-seven nanopeptides derived from the matrix (M) protein of porcine reproductive and respiratory syndrome virus (PRRSV) were screened for their ability to elicit a recall interferon-γ (IFN-γ) response from the splenocytes of BALB/c mice following DNA vaccination and a booster vaccination with recombinant vaccinia virus rWR-PRRSV-M. We identified two peptides (amino acid residues K(93)FITSRCRL and F(57)GYMTFVHF) as CD8(+ )cytotoxic T lymphocyte (CTL) epitopes. These peptides elicited significant numbers of IFN-γ secreting cells, compared with other M nonapeptides and one irrelevant nonapeptide. Bioinformatics analysis showed that the former is an H-2K(d)-restricted CTL epitope, and the latter is an H-2D(d)-restricted CTL epitope. Multiple amino acid sequence alignment among different PRRSV M sequences submitted to GenBank indicated that these two CTL epitopes are strongly conserved, and they should therefore be considered for further research on the mechanisms of cellular immune responses to PRRSV.
has issue date	2011-05-30(xsd:dateTime)
bibo:doi	10.1186/1743-422x-8-263
bibo:pmid	21619712
has license	cc-by
sha1sum (hex)	fd521d37325a60e6ed92aa9bcf4541b9a68ee90e
schema:url	https://doi.org/10.1186/1743-422x-8-263
resource representing a document's title	Identification of CD8(+ )cytotoxic T lymphocyte epitopes from porcine reproductive and respiratory syndrome virus matrix protein in BALB/c mice
has PubMed Central identifier	PMC3126774
has PubMed identifier	21619712
schema:publication	Virol J
resource representing a document's body	covid:fd521d37325a60e6ed92aa9bcf4541b9a68ee90e#body_text
is schema:about of	named entity 'peptides' named entity 'mechanisms' named entity 'conserved' named entity 'cells' named entity 'respiratory' named entity 'DNA vaccination' named entity 'epitope' named entity 'Identification' named entity 'epitopes' named entity 'MATRIX PROTEIN' named entity 'IMMUNE RESPONSES' named entity 'H-2K' named entity 'NUMBERS' named entity 'SEQUENCE ALIGNMENT' named entity 'SUBMITTED' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'IDENTIFICATION' named entity 'THEIR' named entity 'CYTOTOXIC T LYMPHOCYTE' named entity 'DERIVED' named entity 'FOLLOWING' named entity 'MICE' named entity 'BALB' named entity 'PROTEIN ' named entity 'SIGNIFICANT' named entity 'SEQUENCES' named entity 'BOOSTER VACCINATION' named entity 'INDICATED' named entity 'ACID' named entity 'PROTEIN ' named entity 'CD8' named entity 'CELLS' named entity 'IDENTIFIED' named entity 'EPITOPE' named entity 'MICE' named entity 'CONSIDERED' named entity 'BALB' named entity 'CYTOTOXIC T LYMPHOCYTE' named entity 'EPITOPES' named entity 'H-2D' named entity 'GENBANK' named entity 'RESTRICTED' named entity 'RECOMBINANT VACCINIA VIRUS' named entity 'DNA VACCINATION' named entity 'INTERFERON' named entity 'EPITOPES' named entity 'RESEARCH' named entity 'DIFFERENT' named entity 'MECHANISMS' named entity 'AMINO ACID SEQUENCE' named entity 'BIOINFORMATICS ANALYSIS' named entity 'MULTIPLE' named entity 'CD8' named entity 'MATRIX' named entity 'ELICIT' named entity 'RESPONSE' named entity 'CONSERVED' named entity 'CELLULAR' named entity 'SECRETING' named entity 'RECALL' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'COMPARED' named entity 'THESE' named entity 'IFN' named entity 'CTL' named entity 'TWENTY-SEVEN' named entity 'PEPTIDES' named entity 'SPLENOCYTES' covid:arg/fd521d37325a60e6ed92aa9bcf4541b9a68ee90e named entity 'ABILITY TO'

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