About: Lactoferrin a multiple bioactive protein: An overview

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Lactoferrin a multiple bioactive protein: An overview
Creator	Arévalo-Gallegos, Sigifredo Rascón-Cruz, Quintín Abril García-Montoya, Isui Siqueiros Cendón, Tania
Source	Elsevier; Medline; PMC
abstract	Abstract Background Lactoferrin (Lf) is an 80kDa iron-binding glycoprotein of the transferrin family. It is abundant in milk and in most biological fluids and is a cell-secreted molecule that bridges innate and adaptive immune function in mammals. Its protective effects range from anticancer, anti-inflammatory and immune modulator activities to antimicrobial activities against a large number of microorganisms. This wide range of activities is made possible by mechanisms of action involving not only the capacity of Lf to bind iron but also interactions of Lf with molecular and cellular components of both hosts and pathogens. Scope of review This review summarizes the activities of Lf, its regulation and potential applications. Major conclusions The extensive uses of Lf in the treatment of various infectious diseases in animals and humans has been the driving force in Lf research however, a lot of work is required to obtain a better understanding of its activity. General significance The large potential applications of Lf have led scientists to develop this nutraceutical protein for use in feed, food and pharmaceutical applications. This article is part of a Special Issue entitled Molecular Mechanisms of Iron Transport and Disorders.
has issue date	2012-03-31(xsd:dateTime)
bibo:doi	10.1016/j.bbagen.2011.06.018
bibo:pmid	21726601
has license	els-covid
sha1sum (hex)	fd4b55153c383c93c61a4da80abd0c3f6dd26c6a
schema:url	https://doi.org/10.1016/j.bbagen.2011.06.018
resource representing a document's title	Lactoferrin a multiple bioactive protein: An overview
has PubMed Central identifier	PMC7127262
has PubMed identifier	21726601
schema:publication	Biochimica et Biophysica Acta (BBA) - General Subjects
resource representing a document's body	covid:fd4b55153c383c93c61a4da80abd0c3f6dd26c6a#body_text
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