About: Transmissible gastroenteritis virus infection induces cell cycle arrest at S and G2/M phases via p53-dependent pathway

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About: Transmissible gastroenteritis virus infection induces cell cycle arrest at S and G2/M phases via p53-dependent pathway Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Transmissible gastroenteritis virus infection induces cell cycle arrest at S and G2/M phases via p53-dependent pathway
Creator	Huang, Yong Wang, Lili Ding, Li Tong, Dewen Xu, Xingang Du, Qian Zhao, Xiaomin Zhang, Wenlong Dai, Meiling Dong, Feng Huo, Ruichao
Source	Elsevier; Medline; PMC
abstract	Abstract p53 signaling pathway plays an important role in the regulation of cell cycle. Our previous studies have demonstrated that TGEV infection induces the activation of p53 signaling pathway. In this study we investigated the effects of TGEV infection on the cell cycle of host cells and the roles of p53 activation in this process. The results showed that TGEV infection induced cell cycle arrest at S and G2/M phases in both asynchronous and synchronized PK-15 and ST cells, while UV-inactivated TGEV lost the ability of induction of cell cycle arrest. TGEV infection promoted p21 accumulation, down-regulated cell cycle-regulatory proteins cyclins B1, cdc2, cdk2 and PCNA. Further studies showed that inhibition of p53 signaling could attenuate the TGEV-induced S- and G2/M-phase arrest by reversing the expression of p21 and corresponding cyclin/cdk. In addition, TGEV infection of the cells synchronized in various stages of cell cycle showed that viral genomic RNA and subgenomic RNA, and virus titer were higher in the cells released from S-phase- or G2/M phase-synchronized cells than that in the cells released from the G0/G1 phase-synchronized or asynchronous cells after 18h p.i. Taken together, our data suggested that TGEV infection induced S and G2/M phase arrest in host cells, which might provide a favorable condition for viral replication.
has issue date	2013-12-26(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2013.09.036
bibo:pmid	24095767
has license	els-covid
sha1sum (hex)	fd1dd9494d62b3248137dbd4f09ba0c2d200f612
schema:url	https://doi.org/10.1016/j.virusres.2013.09.036
resource representing a document's title	Transmissible gastroenteritis virus infection induces cell cycle arrest at S and G2/M phases via p53-dependent pathway
has PubMed Central identifier	PMC7114465
has PubMed identifier	24095767
schema:publication	Virus Research
resource representing a document's body	covid:fd1dd9494d62b3248137dbd4f09ba0c2d200f612#body_text
is schema:about of	named entity 'TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'DEPENDENT' named entity 'p53 signaling pathway' named entity 'studies' named entity 'cells' named entity 'G2/M phase' named entity 'cdk' named entity 'arrest' named entity 'TGEV' named entity 'ADDITION' named entity 'CONDITION' named entity 'PROVIDE' named entity 'SYNCHRONIZED' named entity 'RNA' named entity 'RELEASED' named entity 'P53 ACTIVATION' named entity 'HIGHER' named entity 'STUDIES' named entity 'REGULATORY PROTEINS' named entity 'INDUCED' named entity 'ATTENUATE' named entity 'CELL CYCLE ARREST' named entity 'VARIOUS' named entity 'EFFECTS' named entity 'RESULTS' named entity 'IMPORTANT' named entity 'VIRAL' named entity 'STUDY' named entity 'PHASES' named entity 'P53' named entity 'PATHWAY' named entity 'EXPRESSION' named entity 'FAVORABLE' named entity 'ARREST' named entity 'INDUCTION' named entity 'INHIBITION' named entity 'TAKEN' named entity 'PHASES' named entity 'SIGNALING' named entity 'VIRUS INFECTION' named entity 'INFECTION' named entity 'HAVE' named entity 'P53' named entity 'CYCLIN' named entity 'VIRAL REPLICATION' named entity 'GENOMIC' named entity 'REGULATION OF CELL CYCLE' named entity 'DATA' named entity 'S-PHASE' named entity 'OUR' named entity 'TITER' named entity 'HOST CELLS' named entity 'P21' named entity 'ACTIVATION' named entity 'ABILITY' named entity 'INFECTION INDUCED' named entity 'ROLES' named entity 'PROCESS' named entity 'PLAYS' named entity 'PCNA' named entity 'CELLS' named entity 'LOST' named entity 'ACCUMULATION' named entity 'CDK2' named entity 'THE CELL' named entity 'INVESTIGATED' named entity 'P53 SIGNALING PATHWAY' named entity 'CDC2' named entity 'DOWN-REGULATED' named entity 'ROLE' named entity 'ASYNCHRONOUS'

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