About: The usefulness of SARS-CoV-2 test positive proportion as a surveillance tool

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The usefulness of SARS-CoV-2 test positive proportion as a surveillance tool
Creator	Cummings, Derek Yang, Bingyi Hitchings, Matt Huang, Angkana Hladish, Thomas Garcia-Carreras, Bernardo Dean, Natalie
source	MedRxiv
abstract	Comparison of COVID-19 case numbers over time and between locations is complicated by limits to virologic testing confirm SARS-CoV-2 infection, leading to under-reporting of incidence, and by variations in testing capacity between locations and over time. The proportion of tested individuals who have tested positive (test positive proportion, TPP) can potentially be used to qualitatively assess the testing capacity of a location; a high TPP could provide evidence that too few people are tested, leading to more under-reporting. In this study we propose a simple model for testing in a population experiencing an epidemic of COVID-19, and derive an expression for TPP in terms of well-defined parameters in the model, related to testing and presence of other pathogens causing COVID-19 like symptoms. We use simulations to show situations in which the TPP is higher or lower than we expect based on these parameters, and the effect of testing strategies on the TPP. In our simulations, we find in the absence of dramatic shifts of testing practices in time or between spatial locations, the TPP is positively correlated with the incidence of infection. As a corollary, the TPP can be used to distinguish between a decline in confirmed cases due to decline in incidence (in which case TPP should decline) and a decline in confirmed cases due to testing constraints (in which case TPP should remain constant). We show that the proportion of tested individuals who present COVID-19 like symptoms (test symptomatic proportion, TSP) encodes similar information to the TPP but has different relationships with the testing parameters, and can thus provide additional information regarding dynamic changes in TPP and incidence. Finally, we compare data on confirmed cases and TPP from US states. We conjecture why states may have higher or lower TPP than average. We suggest that collection of symptom status and age/risk category of tested individuals can aid interpretation of changes in TPP and increase the utility of TPP in assessing the state of the pandemic in different locations and times.
has issue date	2020-07-07(xsd:dateTime)
bibo:doi	10.1101/2020.07.06.20147843
has license	medrxiv
sha1sum (hex)	fce312d632004715262fcd1b82f6e307484b412d
schema:url	https://doi.org/10.1101/2020.07.06.20147843
resource representing a document's title	The usefulness of SARS-CoV-2 test positive proportion as a surveillance tool
resource representing a document's body	covid:fce312d632004715262fcd1b82f6e307484b412d#body_text
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