About: Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells

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About: Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells
Creator	Ren, Lili Li, Bin Ding, Siyuan Feng, Ningguo Ge, Xiaomei Song, Yanhua Zhu, Shu Flavell, Richard Greenberg, Harry
Source	Medline; PMC
abstract	Rotaviruses (RVs), a leading cause of severe diarrhea in young children and many mammalian species, have evolved multiple strategies to counteract the host innate immunity, specifically interferon (IFN) signaling through RV non-structural protein 1 (NSP1). However, whether RV structural components also subvert antiviral response remains under-studied. Here, we found that MAVS, critical for the host RNA sensing pathway upstream of IFN induction, is degraded by the RV RNA methyl- and guanylyl-transferase (VP3) in a host-range-restricted manner. Mechanistically, VP3 localizes to the mitochondria and mediates the phosphorylation of a previously unidentified SPLTSS motif within the MAVS proline-rich region, leading to its proteasomal degradation and blockade of IFN-λ production in RV-infected intestinal epithelial cells. Importantly, VP3 inhibition of MAVS activity contributes to enhanced RV replication and to viral pathogenesis in vivo. Collectively, our findings establish RV VP3 as a viral antagonist of MAVS function in mammals and uncover a novel pathogen-mediated inhibitory mechanism of MAVS signaling.
has issue date	2018-11-21(xsd:dateTime)
bibo:doi	10.7554/elife.39494
bibo:pmid	30460894
has license	cc-by
sha1sum (hex)	fcd821f2f9391938a54442ec69f64e2370597be5
schema:url	https://doi.org/10.7554/elife.39494
resource representing a document's title	Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells
has PubMed Central identifier	PMC6289572
has PubMed identifier	30460894
schema:publication	eLife
resource representing a document's body	covid:fcd821f2f9391938a54442ec69f64e2370597be5#body_text
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