About: Broad-spectrum antiviral and cytocidal activity of cyclopentenylcytosine, a carbocyclic nucleoside targeted at CTP synthetase

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Broad-spectrum antiviral and cytocidal activity of cyclopentenylcytosine, a carbocyclic nucleoside targeted at CTP synthetase Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Broad-spectrum antiviral and cytocidal activity of cyclopentenylcytosine, a carbocyclic nucleoside targeted at CTP synthetase
Creator	De Clercq, Erik Jc'nichi Murase$, ~ Marquez~~, Victor
Source	Elsevier; Medline; PMC
abstract	Abstract Cyclopentenylcytosine (Ce-Cyd) is a broad-spectrum antiviral agent active against DNA viruses [herpes (cytomegalo), pox (vaccinia)], (+)RNA viruses [picorna (polio, Coxsackie, rhino), toga (Sindbis, Semliki forest), corona], (−)RNA viruses [orthomyxo (influenza), paramyxo (parainfluenza, measles), arena (Junin, Tacaribe), rhabdo (vesicular stomatitis)] and (±)RNA viruses (reo). Ce-Cyd is a more potent antiviral agent than its saturated counterpart, cyclopentylcytosine (carbodine, C-Cyd). Ce-Cyd also has potent cytocidal activity against a number of tumor cell lines. The putative target enzyme for both the antiviral and antitumor action of Ce-Cyd is assumed to be the CTP synthetase that converts UTP to CTP. In keeping with this hypothesis was the finding that the antiviral and cytocidal effects of Ce-Cyd are readily reversed by Cyd and, to a lesser extent, Urd, but not by other nucleosides such as dThd or dCyd. In contrast, pyrazofurin and 6-azauridine, two nucleoside analogues that are assumed to interfere with OMP decarboxylase, another enzyme involved in the biosynthesis of pyrimidine ribonucleotides, potentiate the cytocidal activity of Ce-Cyd. Ce-Cyd should be further pursued, as such and in combination with OMP decarboxylase inhibitors, for its therapeutic potential in the treatment of both viral and neoplastic diseases.
has issue date	1991-06-15(xsd:dateTime)
bibo:doi	10.1016/0006-2952(91)90120-t
bibo:pmid	1710119
has license	els-covid
sha1sum (hex)	fccbe2d1dab29119bf24e065b589725df5ae2c7a
schema:url	https://doi.org/10.1016/0006-2952%2891%2990120-t
resource representing a document's title	Broad-spectrum antiviral and cytocidal activity of cyclopentenylcytosine, a carbocyclic nucleoside targeted at CTP synthetase
has PubMed Central identifier	PMC7111160
has PubMed identifier	1710119
schema:publication	Biochemical Pharmacology
resource representing a document's body	covid:fccbe2d1dab29119bf24e065b589725df5ae2c7a#body_text
is schema:about of	named entity 'measles' named entity 'rhabdo' named entity 'viruses' named entity 'Semliki' named entity 'DNA' named entity 'CTP SYNTHETASE' named entity 'ANTIVIRAL' named entity 'CYCLOPENTENYLCYTOSINE' named entity 'CORONA' named entity 'CYD' named entity 'RHINO' named entity 'ARENA' named entity 'SPECTRUM' named entity 'VIRUSES' named entity 'MEASLES' named entity 'CYCLOPENTENYLCYTOSINE' named entity 'BROAD' named entity 'NUCLEOSIDE' named entity 'TARGETED' named entity 'SPECTRUM' named entity 'ACTIVITY' named entity 'BROAD' named entity 'POX' named entity 'ANTIVIRAL AGENT' named entity 'DNA VIRUSES' named entity 'ACTIVE' named entity 'IS A' named entity 'STOMATITIS' named entity 'FOREST' covid:arg/fccbe2d1dab29119bf24e065b589725df5ae2c7a named entity 'corona' named entity 'viruses' named entity 'vaccinia' named entity 'vesicular stomatitis' named entity 'parainfluenza' named entity 'RNA viruses' named entity 'herpes' named entity 'DNA viruses' named entity 'CTP' named entity 'CTP' named entity 'carbocyclic' named entity 'DNA viruses' named entity 'varicella-zoster' named entity 'parainfluenza' named entity 'stomatitis' named entity 'fibroblast' named entity 'biosynthesis' named entity 'murine' named entity 'cell line' named entity 'tumor cell' named entity 'kidney' named entity 'nucleosides' named entity '1.2' named entity 'phosphorylases' named entity 'antiviral drug' named entity 'virus' named entity 'exponential growth' named entity 'antiviral' named entity 'CTP' named entity 'metabolites' named entity 'vaccinia' named entity 'cytocidal' named entity 'antitumor' named entity 'virus replication' named entity 'viruses' named entity 'CTP' named entity 'L1210' named entity 'bovine' named entity 'antitumor' named entity 'CTP' named entity 'viruses' named entity 'HIV' named entity 'azauridine' named entity 'herpes simplex virus type 1' named entity 'antiviral activity' named entity 'cytosine' named entity 'vaccinia' named entity 'cytidine' named entity 'CTP'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software