About: Exchange proteins directly activated by cAMP (EPACs): Emerging therapeutic targets

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Exchange proteins directly activated by cAMP (EPACs): Emerging therapeutic targets
Creator	Zhou, Jia Wang, Pingyuan Cheng, Xiaodong Chen, Haiying Liu, Zhiqing Ye, Na
Source	Elsevier; Medline; PMC
abstract	Exchange proteins directly activated by cAMP (EPACs) are critical cAMP-dependent signaling pathway mediators. The discovery of EPAC proteins has significantly facilitated understanding on cAMP-dependent signaling pathway and efforts along this line open new avenues for developing novel therapeutics for cancer, diabetes, heart failure, inflammation, infections, neurological disorders and other human diseases. Over the past decade, important progress has been made in the identification of EPAC agonists, antagonists and their biological and pharmacological applications. In this review, we briefly summarize recently reported novel functions of EPACs and the discovery of their small molecule modulators. The challenges and future perspectives are also discussed.
has issue date	2017-04-01(xsd:dateTime)
bibo:doi	10.1016/j.bmcl.2017.02.065
bibo:pmid	28283242
has license	green-oa
sha1sum (hex)	fc77f3ec3a89ffc19b5514e1f6cf4315deed2498
schema:url	https://doi.org/10.1016/j.bmcl.2017.02.065
resource representing a document's title	Exchange proteins directly activated by cAMP (EPACs): Emerging therapeutic targets
has PubMed Central identifier	PMC5397994
has PubMed identifier	28283242
schema:publication	Bioorganic & Medicinal Chemistry Letters
resource representing a document's body	covid:fc77f3ec3a89ffc19b5514e1f6cf4315deed2498#body_text
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