About: Neutralization Assay with SARS-CoV-1 and SARS-CoV-2 Spike Pseudotyped Murine Leukemia Virions

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About: Neutralization Assay with SARS-CoV-1 and SARS-CoV-2 Spike Pseudotyped Murine Leukemia Virions Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Neutralization Assay with SARS-CoV-1 and SARS-CoV-2 Spike Pseudotyped Murine Leukemia Virions
Creator	Planelles, Vicente Cisneros, Isabel Coiras, Mayte Delgado, Julio Lama, Juan Larragoite, Erin Rondina, Matthew Rychert, Jenna Slev, Patricia Spivak, Adam Zheng, Yue
Source	BioRxiv
abstract	Antibody neutralization is an important prognostic factor in many viral diseases. To easily and rapidly measure titers of neutralizing antibodies in serum or plasma, we developed pseudovirion particles composed of the spike glycoprotein of SARS-CoV-2 incorporated onto murine leukemia virus capsids and a modified minimal MLV genome encoding firefly luciferase. These pseudovirions provide a practical means of assessing immune responses under laboratory conditions consistent with biocontainment level 2.
has issue date	2020-07-18(xsd:dateTime)
bibo:doi	10.1101/2020.07.17.207563
has license	biorxiv
sha1sum (hex)	fc6e0a777f7153bb73241fe24f906b53b831a86c
schema:url	https://doi.org/10.1101/2020.07.17.207563
resource representing a document's title	Neutralization Assay with SARS-CoV-1 and SARS-CoV-2 Spike Pseudotyped Murine Leukemia Virions
schema:publication	bioRxiv
resource representing a document's body	covid:fc6e0a777f7153bb73241fe24f906b53b831a86c#body_text
is schema:about of	named entity 'incorporated' named entity 'spike' named entity 'SARS-CoV-2' named entity 'Leukemia' named entity 'Virions' named entity 'neutralizing antibodies' named entity 'receptor' named entity 'protein' named entity 'RBD' named entity 'serum' named entity 'SARS-CoV-1' named entity 'Spike' named entity 'neutralizing antibodies' named entity 'murine leukemia virus' named entity 'firefly luciferase' named entity 'genome' named entity 'biocontainment' named entity 'laboratory conditions' named entity 'SARS-CoV-2' named entity 'Pseudotyped' named entity 'ACE2' named entity 'glycoproteins' named entity 'genbank' named entity 'positive test' named entity 'SARS-CoV-2' named entity 'Viruses' named entity 'pseudotyped' named entity 'HEK293T' named entity 'MLV' named entity 'COVID' named entity 'neutralization test' named entity 'positive control' named entity 'RBD' named entity 'receptor binding domain' named entity 'HIV-1' named entity 'virus' named entity 'coronavirus disease' named entity '293T cells' named entity 'retroviral' named entity 'Dulbecco's modified Eagle's medium' named entity 'HIV-1' named entity 'lentivirus' named entity '37°C' named entity 'MLV' named entity 'amino acids' named entity 'PCR' named entity 'kilobases' named entity 'antibody' named entity 'addgene' named entity 'Vero E6' named entity 'biocontainment' named entity 'Structural studies' named entity 'peptide' named entity '293T' named entity 'codon' named entity 'plasmid' named entity 'SARS-CoV-1' named entity 'SARS-CoV-1' named entity 'assay' named entity 'transfection' named entity 'plasma' named entity 'SARS-CoV-2' named entity 'influenza infection' named entity 'HIV-1' named entity 'ACE-2' named entity 'pseudotyped' named entity 'endoplasmic reticulum' named entity 'RBD' named entity 'Luciferase' named entity 'pseudotype' named entity 'viruses' named entity 'viruses' named entity 'plasmid' named entity '37°C'

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