About: Characterization of a Novel Influenza Virus in Cattle and Swine: Proposal for a New Genus in the Orthomyxoviridae Family

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About: Characterization of a Novel Influenza Virus in Cattle and Swine: Proposal for a New Genus in the Orthomyxoviridae Family Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Characterization of a Novel Influenza Virus in Cattle and Swine: Proposal for a New Genus in the Orthomyxoviridae Family
Creator	Nelson, Eric Palese, Peter Li, Feng Huang, Bing Liu, Runxia Sheng, Zizhang Wang, Dan Hause, Ben Lu, Wuxun Collin, Emily Li, F Bm, Hause Ea, Collin Ea, Nelson
Source	Medline; PMC
abstract	We have recently reported the isolation of a novel virus, provisionally designated C/swine/Oklahoma/1334/2011 (C/OK), with 50% overall homology to human influenza C viruses (ICV), from a pig in Oklahoma. Deep RNA sequencing of C/OK virus found a matrix 1 (M1) protein expression strategy that differed from that of ICV. The novelty of C/OK virus prompted us to investigate whether C/OK virus could exist in a nonswine species. Significantly, we found that C/OK virus was widespread in U.S. bovine herds, as demonstrated by reverse transcription (RT)-PCR and serological assays. Genome sequencing of three bovine viruses isolated from two herds in different states further confirmed these findings. To determine whether swine/bovine C/OK viruses can undergo reassortment with human ICV, and to clarify the taxonomic status of C/OK, in vitro reassortment and serological typing by agar gel immunodiffusion (AGID) were conducted. In vitro reassortment using two human ICV and two swine and bovine C/OK viruses demonstrated that human ICV and C/OK viruses were unable to reassort and produce viable progeny. Antigenically, no cross-recognition of detergent split virions was observed in AGID between human and nonhuman viruses by using polyclonal antibodies that were reactive to cognate antigens. Taken together, these results demonstrate that C/OK virus is genetically and antigenically distinct from ICV. The classification of the new virus in a separate genus of the Orthomyxoviridae family is proposed. The finding of C/OK virus in swine and bovine indicates that this new virus may spread and establish infection in other mammals, including humans.
has issue date	2014-03-04(xsd:dateTime)
bibo:doi	10.1128/mbio.00031-14
bibo:pmid	24595369
has license	cc-by-nc-sa
sha1sum (hex)	fc6489e42c4a336fd64bd4b82639037087aa60fe
schema:url	https://doi.org/10.1128/mbio.00031-14
resource representing a document's title	Characterization of a Novel Influenza Virus in Cattle and Swine: Proposal for a New Genus in the Orthomyxoviridae Family
has PubMed Central identifier	PMC3958797
has PubMed identifier	24595369
schema:publication	mBio
resource representing a document's body	covid:fc6489e42c4a336fd64bd4b82639037087aa60fe#body_text
is schema:about of	named entity 'PROPOSAL' named entity 'ICV' named entity 'FINDINGS' named entity 'HUMAN' named entity 'ISOLATED' named entity 'USING' named entity 'PROMPTED' named entity 'PCR' named entity 'CLARIFY' named entity 'DIFFERENT' named entity 'RECENTLY' named entity 'PRODUCE' named entity 'SEROLOGICAL' named entity 'REACTIVE' named entity 'THESE' named entity 'DEMONSTRATED' named entity 'BOVINE' named entity 'POLYCLONAL ANTIBODIES' named entity 'IN VITRO' named entity 'ISOLATION' named entity 'HUMAN INFLUENZA' named entity 'reassortment' named entity 'swine' named entity 'assays' named entity 'ICV' named entity 'swine' named entity 'polyclonal antibodies' named entity 'swine' named entity 'virus' named entity 'Swine' named entity 'DETERGENT' named entity 'EXIST' named entity 'U.S.' named entity 'INFLUENZA VIRUS' named entity 'FAMILY' named entity 'OKLAHOMA' named entity 'GENOME SEQUENCING' named entity 'VIABLE' named entity 'HOMOLOGY' named entity 'STATES' named entity 'TO INVESTIGATE' named entity 'SWINE' named entity 'CHARACTERIZATION' named entity 'CATTLE' named entity 'NEW GENUS' named entity 'RNA SEQUENCING' named entity 'FOUND' named entity 'SWINE' named entity 'INFLUENZA C VIRUSES' named entity 'STATUS' named entity 'CROSS' named entity 'STRATEGY' named entity 'OBSERVED' named entity 'TAKEN' named entity 'PIG' named entity 'WIDESPREAD' named entity 'SPLIT' named entity 'DEEP' named entity 'CONFIRMED' named entity 'VIRIONS' named entity 'HAVE' named entity 'ORTHOMYXOVIRIDAE' named entity 'NOVEL' named entity '50%' named entity 'NOVEL' named entity 'ANTIGENS' named entity 'SPECIES' named entity 'DETERMINE'

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