About: Transcriptomically Revealed Oligo-Fucoidan Enhances the Immune System and Protects Hepatocytes via the ASGPR/STAT3/HNF4A Axis

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About: Transcriptomically Revealed Oligo-Fucoidan Enhances the Immune System and Protects Hepatocytes via the ASGPR/STAT3/HNF4A Axis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Transcriptomically Revealed Oligo-Fucoidan Enhances the Immune System and Protects Hepatocytes via the ASGPR/STAT3/HNF4A Axis
Creator	Cheng, Chun-Chia Hsiao, Ming-Chen Lee, Hao-Wei Lin, Kuan-Hao Yang, Wan-Yu Yuh, Chiou-Hwa
Source	Medline; PMC
abstract	Oligo-fucoidan, a sulfated polysaccharide extracted from brown seaweed, exhibits anti-inflammatory and anti-tumor effects. However, the knowledge concerning the detailed mechanism of oligo-fucoidan on liver cells is obscure. In this study, we investigate the effect of oligo-fucoidan in normal hepatocytes by transcriptomic analysis. Using an oligo-fucoidan oral gavage in wild-type adult zebrafish, we find that oligo-fucoidan pretreatment enhances the immune system and anti-viral genes in hepatocytes. Oligo-fucoidan pretreatment also decreases the expression of lipogenic enzymes and liver fibrosis genes. Using pathway analysis, we identify hepatocyte nuclear factor 4 alpha (HNF4A) to be the potential driver gene. We further investigate whether hepatocyte nuclear factor 4 alpha (HNF4A) could be induced by oligo-fucoidan and the underlying mechanism. Therefore, a normal hepatocyte clone 9 cell as an in vitro model was used. We demonstrate that oligo-fucoidan increases cell viability, Cyp3a4 activity, and Hnf4a expression in clone 9 cells. We further demonstrate that oligo-fucoidan might bind to asialoglycoprotein receptors (ASGPR) in normal hepatocytes through both in vitro and in vivo competition assays. This binding, consequently activating the signal transducer and activator of transcription 3 (STAT3), increases the expression of the P1 isoform of HNF4A. According to our data, we suggest that oligo-fucoidan not only enhances the gene expression associated with anti-viral ability and immunity, but also increases P1-HNF4A levels through ASGPR/STAT3 axis, resulting in protecting hepatocytes.
has issue date	2020-06-12(xsd:dateTime)
bibo:doi	10.3390/biom10060898
bibo:pmid	32545625
has license	cc-by
sha1sum (hex)	fc396e20999242ea5fa1051d7f1653bd2d0dedc8
schema:url	https://doi.org/10.3390/biom10060898
resource representing a document's title	Transcriptomically Revealed Oligo-Fucoidan Enhances the Immune System and Protects Hepatocytes via the ASGPR/STAT3/HNF4A Axis
has PubMed Central identifier	PMC7355575
has PubMed identifier	32545625
schema:publication	Biomolecules
resource representing a document's body	covid:fc396e20999242ea5fa1051d7f1653bd2d0dedc8#body_text
is schema:about of	named entity 'immunity' named entity 'expression' named entity 'demonstrate' named entity 'mechanism' named entity 'normal' named entity 'asialoglycoprotein' named entity 'competition' named entity 'Axis' covid:arg/fc396e20999242ea5fa1051d7f1653bd2d0dedc8 named entity 'brown seaweed' named entity 'anti-viral' named entity 'vivo' named entity 'activity' named entity 'axis' named entity 'hepatocyte nuclear factor 4 alpha' named entity 'hepatocyte' named entity 'gavage' named entity 'bind' named entity 'clone' named entity 'hepatocytes' named entity 'gene' named entity 'hepatocytes' named entity 'anti-viral' named entity 'cell' named entity 'mechanism' named entity 'immune system' named entity 'Hepatocytes' named entity 'Oligo' named entity 'fucoidan' named entity 'fucoidan' named entity 'oligo' named entity 'gavage' named entity 'fucoidan' named entity 'Cyp3a4' named entity 'hepatocytes' named entity 'clone' named entity 'Transcriptomically' named entity 'liver' named entity 'qPCR' named entity 'Clone' named entity 'Clone' named entity 'transcriptome analysis' named entity 'signal transducer' named entity 'hepatocytes' named entity 'liver' named entity 'downregulated' named entity 'fucoidan' named entity 'signaling cascades' named entity 'hepatocytes' named entity 'liver cancer' named entity 'transfected' named entity 'anti-viral' named entity 'enzyme' named entity 'anti-viral' named entity 'JAK2' named entity 'Clone' named entity 'fibrosis' named entity 'qPCR' named entity 'Japan' named entity 'oligo' named entity 'Western blots' named entity 'liver cancer' named entity 'µCi' named entity 'fucoidan' named entity 'expression analysis' named entity 'Water Soluble' named entity 'oligo' named entity 'JAK2' named entity 'C-type lectin' named entity 'Hnf4a' named entity 'Hnf4a' named entity 'receptor' named entity 'oligo' named entity 'transfected' named entity 'fucoidan' named entity 'zebrafish'

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