About: Characterization of anti-MERS-CoV antibodies against various recombinant structural antigens of MERS-CoV in an imported case in China

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About: Characterization of anti-MERS-CoV antibodies against various recombinant structural antigens of MERS-CoV in an imported case in China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Characterization of anti-MERS-CoV antibodies against various recombinant structural antigens of MERS-CoV in an imported case in China
Creator	Ke, Changwen Deng, Yao Tan, Wenjie Wang, Wenling Song, Tie Wu, Guizhen Wang, Huijuan Lan, Jiaming
Source	Medline; PMC
abstract	The first imported case of Middle East respiratory syndrome (MERS) in China recently occurred, allowing for the characterization of antibody titers in a series of the patient's sera using the following methods based on recombinant viral structural antigens: inactivated MERS coronavirus (MERS-CoV) enzyme-linked immunosorbent assay (ELISA), recombinant MERS-CoV spike (S, or fragments of S) ELISA, nucleoprotein (NP) ELISA and MERS S pseudovirus particle-based neutralization test (ppNT). A longitudinal profile of the infection showed that seroconversion detected by ELISAs based on the recombinant extracellular domain, S, S1 and receptor-binding domain (RBD) antigens occurred as early as neutralizing antibodies were detected by the ppNT and earlier than antibodies were detected by the inactivated MERS-CoV and N-terminal domain (NTD) ELISAs. Antibodies detected by the NP ELISA occurred last. Strong correlations were found between the S1, RBD and NP ELISAs and the inactivated MERS-CoV ELISA. The S and RBD ELISAs were highly correlated with the commercial S1 ELISA. The S ELISA strongly correlated with the ppNT, although the MERS-CoV, S1, NTD and RBD ELISAs were also significantly correlated with the ppNT (P<0.001).
has issue date	2016-11-09(xsd:dateTime)
bibo:doi	10.1038/emi.2016.114
bibo:pmid	27826140
has license	cc-by
sha1sum (hex)	fc221d8af0a962a17778721217b1f9f914f353b4
schema:url	https://doi.org/10.1038/emi.2016.114
resource representing a document's title	Characterization of anti-MERS-CoV antibodies against various recombinant structural antigens of MERS-CoV in an imported case in China
has PubMed Central identifier	PMC5148018
has PubMed identifier	27826140
schema:publication	Emerg Microbes Infect
resource representing a document's body	covid:fc221d8af0a962a17778721217b1f9f914f353b4#body_text
is schema:about of	named entity 'structural' named entity 'seroconversion' named entity 'detected' named entity 'recombinant' named entity 'pseudovirus' named entity 'CHARACTERIZATION' named entity 'PSEUDOVIRUS' named entity 'ALLOWING' named entity 'VIRAL' named entity 'CHINA' named entity 'SEROCONVERSION' named entity 'ENZYME-LINKED IMMUNOSORBENT ASSAY' named entity 'METHODS' named entity 'VARIOUS' named entity 'MERS-COV' named entity 'FOLLOWING' named entity 'CORRELATIONS' named entity '28S' named entity 'IMPORTED' named entity 'NUCLEOPROTEIN' named entity 'ELISA' named entity 'CASE' named entity 'EARLIER' named entity 'RECOMBINANT' named entity 'OCCURRED' named entity 'BINDING' named entity 'N-TERMINAL ' named entity 'RECOMBINANT' named entity 'MERS' named entity 'STRUCTURAL' named entity 'CHINA' named entity 'ANTIGENS' named entity 'IMPORTED' named entity 'STRUCTURAL' named entity 'RECEPTOR' named entity 'INFECTION' named entity 'ANTIBODIES' named entity 'RBD' named entity 'DOMAIN' named entity 'CORRELATED' named entity 'BASED' named entity 'NTD' named entity 'SERIES' named entity 'PATIENT' named entity 'DETECTED' named entity 'PROFILE' named entity 'ANTIBODY TITERS' named entity 'RECENTLY' named entity 'COMMERCIAL' named entity 'NEUTRALIZING ANTIBODIES' named entity 'SERA' named entity '27S' named entity 'NEUTRALIZATION TEST' named entity 'SPIKE' named entity 'STRONG' named entity 'CASE' named entity 'MERS-COV' named entity 'HIGHLY' named entity 'USING' named entity 'PARTICLE' named entity 'CHARACTERIZATION' named entity 'FRAGMENTS' named entity 'FOUND' named entity 'ANTIGENS' named entity 'EARLY' named entity 'ANTIBODIES' named entity 'MERS CORONAVIRUS' named entity 'EXTRACELLULAR DOMAIN' named entity 'MIDDLE EAST RESPIRATORY SYNDROME ' named entity 'LONGITUDINAL' named entity 'INACTIVATED' covid:arg/fc221d8af0a962a17778721217b1f9f914f353b4 named entity 'profile' named entity 'detected'

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