About: Artemisinin analogue SM934 attenuate collagen-induced arthritis by suppressing T follicular helper cells and T helper 17 cells

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About: Artemisinin analogue SM934 attenuate collagen-induced arthritis by suppressing T follicular helper cells and T helper 17 cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Artemisinin analogue SM934 attenuate collagen-induced arthritis by suppressing T follicular helper cells and T helper 17 cells
Creator	He, Shi-Jun Lin, Ze-Min Tang, Wei Yang, Xiao-Qian Zhu, Feng-Hua Zuo, Jian-Ping
Source	PMC
abstract	SM934 is an artemisinin analogue with immunosuppressive properties and potent therapeutic activity against lupus-like diseases in autoimmune mice. In this report, the therapeutic efficacy and underlying mechanisms of SM934 on rheumatoid arthritis (RA) was investigated using collagen-induced arthritis (CIA) in DBA/1J mice. We demonstrated that SM934 treatment alleviate the severity of arthritis in CIA mice with established manifestations. The therapeutic benefits were associated with ameliorated joint swelling and reduced extent of bone erosion and destruction. Further, administration of SM934 diminished the development of T follicular helper (Tfh) cells and Th17 cells and suppressed the production of pathogenic antibodies, without altering the proportion of germinal center B cells. Ex vivo, SM934 treatment inhibited the bovine type II collagen (CII) induced proliferation and inflammatory cytokines secretion of CII -reactive T cells. In vitro, SM934 impeded the polarization of naïve CD4(+) T cells into Tfh cells and the expression of its transcript factor Bcl-6. Moreover, SM934 decreased the IL-21-producing CD4(+) T cells and dampened the IL-21 downstream signaling through STAT3. These finding offered the convincing evidence that artemisinin derivative might attenuate RA by simultaneously interfering with the generation of Tfh cells and Th17 cells as well as the subsequent antibody-mediated immune responses.
has issue date	2016-11-29(xsd:dateTime)
bibo:doi	10.1038/srep38115
bibo:pmid	27897259
has license	cc-by
sha1sum (hex)	fbf232152712b5e379797c6b0008bb7926001bb7
schema:url	https://doi.org/10.1038/srep38115
resource representing a document's title	Artemisinin analogue SM934 attenuate collagen-induced arthritis by suppressing T follicular helper cells and T helper 17 cells
has PubMed Central identifier	PMC5126690
has PubMed identifier	27897259
schema:publication	Sci Rep
resource representing a document's body	covid:fbf232152712b5e379797c6b0008bb7926001bb7#body_text
is schema:about of	named entity 'OPEN' named entity 'DBA' named entity 'T helper' covid:arg/fbf232152712b5e379797c6b0008bb7926001bb7 named entity 'REDUCED' named entity 'REPORT' named entity 'BONE EROSION' named entity 'CIA' named entity 'ACTIVITY' named entity 'SEVERITY' named entity 'LUPUS' named entity 'RHEUMATOID ARTHRITIS' named entity 'DISEASES' named entity 'DEMONSTRATED' named entity 'INVESTIGATED' named entity 'COLLAGEN-INDUCED ARTHRITIS' named entity 'UNDERLYING' named entity 'DBA' named entity 'THERAPEUTIC' named entity 'BENEFITS' named entity 'ARTEMISININ' named entity 'ASSOCIATED WITH' named entity 'LIKE' named entity 'PROPERTIES' named entity 'THERAPEUTIC EFFICACY' named entity 'SM934' named entity 'SUPPRESSING' named entity 'COLLAGEN-INDUCED ARTHRITIS' named entity 'AUTOIMMUNE' named entity 'SM934' named entity 'T HELPER' named entity 'T FOLLICULAR HELPER CELLS' named entity 'CELLS' named entity 'ANALOGUE' named entity 'ATTENUATE' named entity 'MANIFESTATIONS' named entity 'ANALOGUE' named entity 'ESTABLISHED' named entity 'ARTHRITIS' named entity 'MECHANISMS' named entity 'MICE' named entity 'TREATMENT' named entity 'USING' named entity 'JOINT SWELLING' named entity 'ARTEMISININ' named entity 'DESTRUCTION' named entity 'EXTENT OF' named entity 'IMMUNOSUPPRESSIVE' named entity 'investigated' named entity 'therapeutic' named entity 'collagen-induced arthritis' named entity 'therapeutic benefits' named entity 'autoimmune' named entity 'mice' named entity 'rheumatoid arthritis' named entity 'mice' named entity 'helper cells' named entity 'collagen-induced arthritis' named entity 'FoxP3' named entity 'OVA' named entity 'IL-1β' named entity 'IL-17' named entity 'costimulatory' named entity 'Tfh' named entity 'CIA' named entity 'CIA' named entity 'Alexa Fluor' named entity 'mAb' named entity 'Th1' named entity 'transcription factor' named entity 'Th17' named entity 'IL-21' named entity 'multiple comparison' named entity 'GAPDH' named entity 'anti-PD-1' named entity 'splenocytes'

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