About: Sustained high serum malondialdehyde levels are associated with severity and mortality in septic patients

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Sustained high serum malondialdehyde levels are associated with severity and mortality in septic patients
Creator	Solé-Violán, Jordi Ferreres, José Lorente, Leonardo Martín, María Abreu-González, Pedro Cabrera, Judith Domínguez-Rodriguez, Alberto Díaz, César Igeño, Jose Jiménez, Alejandro Labarta, Lorenzo
Source	PMC
abstract	INTRODUCTION: There is a hyperoxidative state in sepsis. The objective of this study was to determine serum malondialdehyde (MDA) levels during the first week of follow up, whether such levels are associated with severity during the first week and whether non-surviving patients showed higher MDA levels than survivors during the first week. METHODS: We performed an observational, prospective, multicenter study in six Spanish Intensive Care Units. Serum levels of MDA were measured in 328 patients (215 survivors and 113 non-survivors) with severe sepsis at days one, four and eight of diagnosis, and in 100 healthy controls. The primary endpoint was 30-day mortality and the secondary endpoint was six -month mortality. The association between continuous variables was carried out using Spearman’s rank correlation coefficient. Cox regression analysis was applied to determine the independent contribution of serum MDA levels on the prediction of 30-day and 6-month mortality. Hazard ratio (HR) and 95% confidence intervals (CI) were calculated as measures of the clinical impact of the predictor variables. RESULTS: We found higher serum MDA in septic patients at day one (p < 0.001), day four (p < 0.001) and day eight (p < 0.001) of diagnosis than in healthy controls. Serum MDA was lower in surviving than non-surviving septic patients at day one (p < 0.001), day four (p < 0.001) and day eight (p < 0.001). Serum MDA levels were positively correlated with lactic acid and SOFA during the first week. Finally, serum MDA levels were associated with 30-day mortality (HR = 1.05; 95% CI = 1.02-1.09; p = 0.005) and six-month mortality (hazard ratio (HR) = 1.05; 95% CI = 1.02-1.09; p = 0.003) after controlling for lactic acid levels, acute physiology and chronic health evaluation (APACHE)-II, diabetes mellitus, bloodstream infection and chronic renal failure. CONCLUSIONS: To our knowledge, this is the largest series providing data on the oxidative state in septic patients to date. The novel finding is that high serum MDA levels sustained throughout the first week of follow up were associated with severity and mortality in septic patients.
has issue date	2013-12-11(xsd:dateTime)
bibo:doi	10.1186/cc13155
bibo:pmid	24326199
has license	cc-by
sha1sum (hex)	fbc71b4b125e8c1c9206b2e444ae9b48f54ba571
schema:url	https://doi.org/10.1186/cc13155
resource representing a document's title	Sustained high serum malondialdehyde levels are associated with severity and mortality in septic patients
has PubMed Central identifier	PMC4055989
has PubMed identifier	24326199
schema:publication	Crit Care
resource representing a document's body	covid:fbc71b4b125e8c1c9206b2e444ae9b48f54ba571#body_text
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