About: Evaluation of local and systemic immune responses in pigs experimentally challenged with porcine reproductive and respiratory syndrome virus

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About: Evaluation of local and systemic immune responses in pigs experimentally challenged with porcine reproductive and respiratory syndrome virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evaluation of local and systemic immune responses in pigs experimentally challenged with porcine reproductive and respiratory syndrome virus
Creator	Khatun, Amina Kim, Won-Il Park, Choi-Kyu Lee, Sang-Myeong Kim, Bumseok Jeong, Chang-Gi Nazki, Salik Gu, Suna Kim, Seung-Chai Lee, Sim-In Park, Ji-Hyo Yang, Myoun-Sik Mattoo, Salam
Source	Medline; PMC
abstract	The host-associated defence system responsible for the clearance of porcine reproductive and respiratory syndrome virus (PRRSV) from infected pigs is currently poorly understood. To better understand the dynamics of host–pathogen interactions, seventy-five of 100 pigs infected with PRRSV-JA142 and 25 control pigs were euthanized at 3, 10, 21, 28 and 35 days post-challenge (dpc). Blood, lung, bronchoalveolar lavage (BAL) and bronchial lymph node (BLN) samples were collected to evaluate the cellular immune responses. The humoral responses were evaluated by measuring the levels of anti-PRRSV IgG and serum virus-neutralizing (SVN) antibodies. Consequently, the highest viral loads in the sera and lungs of the infected pigs were detected between 3 and 10 dpc, and these resulted in moderate to mild interstitial pneumonia, which resolved accompanied by the clearance of most of the virus by 28 dpc. At peak viremia, the frequencies of alveolar macrophages in infected pigs were significantly decreased, whereas the monocyte-derived DC/macrophage and conventional DC frequencies were increased, and these effects coincided with the early induction of local T-cell responses and the presence of proinflammatory cytokines/chemokines in the lungs, BAL, and BLN as early as 10 dpc. Conversely, the systemic T-cell responses measured in the peripheral blood mononuclear cells were delayed and significantly induced only after the peak viremic stage between 3 and 10 dpc. Taken together, our results suggest that activation of immune responses in the lung could be the key elements for restraining PRRSV through the early induction of T-cell responses at the sites of virus replication.
has issue date	2020-05-13(xsd:dateTime)
bibo:doi	10.1186/s13567-020-00789-7
bibo:pmid	32404209
has license	cc-by
sha1sum (hex)	fbbf06067b94abc5b6ad6cfc42c78877958601a8
schema:url	https://doi.org/10.1186/s13567-020-00789-7
resource representing a document's title	Evaluation of local and systemic immune responses in pigs experimentally challenged with porcine reproductive and respiratory syndrome virus
has PubMed Central identifier	PMC7222343
has PubMed identifier	32404209
schema:publication	Vet Res
resource representing a document's body	covid:fbbf06067b94abc5b6ad6cfc42c78877958601a8#body_text
is schema:about of	named entity 'early' named entity 'responses' named entity 'SVN' named entity 'porcine' named entity 'induction' named entity 'responsible' named entity 'pigs' named entity 'STAGE' named entity 'INFECTED' named entity 'SERUM' named entity 'ALVEOLAR MACROPHAGES' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'evaluated' named entity 'virus' named entity 'control' named entity 'loads' named entity 'chemokines' named entity 'infected' named entity 'lung' named entity 'mild' named entity 'T-cell' named entity 'chemokines' named entity 'lungs' named entity 'host-pathogen interactions' named entity 'cellular immune responses' named entity 'humoral responses' named entity 'lung' named entity 'T-cell' named entity 'serum' named entity 'porcine reproductive and respiratory syndrome virus' named entity 'IL-8' named entity 'virus' named entity 'tissue damage' named entity 'GraphPad Prism' named entity 'Foster City' named entity 'viremia' named entity 'PRRSV' named entity 'alveolar macrophages' named entity 'Miltenyi Biotec' named entity 'viral load' named entity 'PRRSV' named entity '37 °C' named entity 'viremia' named entity 'secondary lymphoid tissues' named entity 'antibodies' named entity 'staining' named entity 'BALF' named entity 'monocytes' named entity 'TNF-α' named entity 'foetal bovine serum' named entity 'NK cells' named entity 'lungs' named entity 'infection' named entity 'mast cells' named entity 'BALF' named entity 'macrophage' named entity 'immune responses' named entity 'RNA extraction' named entity 'infectivity' named entity 'LCMV' named entity 'FoxP3' named entity 'Tregs' named entity 'lymphocytes' named entity 'NKp46' named entity 'NK cells' named entity 'influenza' named entity 'porcine' named entity 'bronchoalveolar lavage' named entity 'cDNA'

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