About: Fish Oil-Fed Mice Have Impaired Resistance to Influenza Infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Fish Oil-Fed Mice Have Impaired Resistance to Influenza Infection
Creator	Beck, Melinda Karlsson, Erik Schwerbrock, Nicole Sheridan, Patricia Shi, Qing
Source	Medline; PMC
abstract	Dietary fish oils, rich in (n-3) PUFA, including eicosapentaenoic acid and docosahexaenoic acid, have been shown to have antiinflammatory properties. Although the antiinflammatory properties of fish oil may be beneficial during a chronic inflammatory illness, the same antiinflammatory properties can suppress the inflammatory responses necessary to combat acute viral infection. Given that (n-3) fatty acid-rich fish oil supplementation is on the rise and with the increasing threat of an influenza pandemic, we tested the effect of fish oil feeding for 2 wk on the immune response to influenza virus infection. Male C57BL/6 mice fed either a menhaden fish oil/corn oil diet (4 g fish oil:1 g corn oil, wt:wt at 5 g/100 g diet) or a control corn oil diet were infected with influenza A/PuertoRico/8/34 and analyzed for lung pathology and immune function. Although fish oil-fed mice had lower lung inflammation compared with controls, fish oil feeding also resulted in a 40% higher mortality rate, a 70% higher lung viral load at d 7 post infection, and a prolonged recovery period following infection. Although splenic natural killer (NK) cell activity was suppressed in fish oil-fed mice, lung NK activity was not affected. Additionally, lungs of infected fish oil-fed mice had significantly fewer CD8(+) T cells and decreased mRNA expression of macrophage inflammatory protein-1-α, tumor necrosis factor-α, and interleukin-6. These results suggest that the antiinflammatory properties of fish oil feeding can alter the immune response to influenza infection, resulting in increased morbidity and mortality.
has issue date	2009-06-23(xsd:dateTime)
bibo:doi	10.3945/jn.109.108027
bibo:pmid	19549756
has license	no-cc
sha1sum (hex)	fba03517af2ead8777059308f6158076dfd38f91
schema:url	https://doi.org/10.3945/jn.109.108027
resource representing a document's title	Fish Oil-Fed Mice Have Impaired Resistance to Influenza Infection
has PubMed Central identifier	PMC2709305
has PubMed identifier	19549756
schema:publication	J Nutr
resource representing a document's body	covid:fba03517af2ead8777059308f6158076dfd38f91#body_text
is schema:about of	named entity 'CHRONIC' named entity 'CELL ACTIVITY' named entity 'FED' named entity 'AFFECTED' named entity 'VIRAL LOAD' named entity 'HIGHER' named entity 'ALTER' named entity 'USED' named entity 'LUNG INFLAMMATION' named entity 'RISE' named entity 'INFECTION' named entity 'ACUTE' named entity 'COMPARED' named entity 'INFLAMMATORY RESPONSES' named entity 'THREAT' named entity 'LUNGS' named entity 'SPLENIC' named entity 'MORBIDITY AND MORTALITY' named entity 'INFLUENZA VIRUS' named entity 'PROPERTIES' named entity 'INCREASED' named entity 'RESPONSE TO' named entity 'COMBAT' named entity 'T CELLS' named entity 'TCID' named entity 'FISH OIL' named entity 'INTERFERON' named entity 'HAVE' named entity 'activity' named entity 'inflammatory' named entity 'supplementation' named entity 'higher' named entity 'fed' named entity 'feeding' named entity 'Given' named entity 'T cells' named entity 'protein' named entity 'Mice' named entity 'C57BL' named entity 'MACROPHAGE INFLAMMATORY PROTEIN-1' named entity 'MENHADEN' named entity 'NECESSARY' named entity 'INFLUENZA A' named entity 'IMPAIRED' named entity 'HAVE' named entity 'MAY BE' named entity 'OIL' named entity 'DIET' named entity 'SUPPRESS' named entity 'INCREASING' named entity 'LUNG' named entity 'PHYCOERYTHRIN' named entity 'ANALYZED' named entity 'SUPPRESSED' named entity 'LOWER' named entity 'EICOSAPENTAENOIC ACID' named entity 'NK ACTIVITY' named entity 'ABBREVIATIONS' named entity 'FISH OILS' named entity 'IMMUNE FUNCTION' named entity 'RECOVERY PERIOD' named entity 'RESISTANCE TO' named entity 'FISH OIL' named entity 'MICE' named entity 'INFLUENZA INFECTION' named entity 'CORN OIL' named entity '2F8' named entity 'CD8' named entity '70%' named entity 'RESULTING IN' named entity 'PUFA' named entity 'ANTIINFLAMMATORY' named entity 'GIVEN' named entity 'INFLUENZA PANDEMIC' named entity 'DIETARY FISH' named entity 'POST' named entity 'SUGGEST'

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