About: Systemic infection of avian influenza A virus H5N1 subtype in humans

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Systemic infection of avian influenza A virus H5N1 subtype in humans
Creator	Yuen, Kwok-Yung Li, Kang-Sheng Chen Phd, Honglin Fu Ng, Wai Guan Phd, Yi Huang Msc, Kai Zhang Msc, Zengfeng Zhang Phd, Jinxia
source	Elsevier; Medline; PMC
abstract	Summary The viral dissemination in a patient with avian influenza A subtype H5N1 infection was retrospectively studied by the immunohistochemical localization of viral nucleoprotein antigen. The pathology was marked by diffuse alveolar damage, lymphoid depletion, and reactive hemophagocytic syndrome. Besides the lung and the upper respiratory tract, viral antigen was detected in the small and large intestinal epithelial cells, hematopoietic cells in the bone marrow, glial cells and neurons of the brain, and lymphocytes. The results confirmed that H5N1 virus disseminated to multiple organs beyond the respiratory system. However, specific pathological changes were noted in the respiratory system only, and productive viral replication confirmed by culture was noted only in the lung. More postmortem studies are needed to elucidate the pathogenesis of this highly fatal zoonotic disease.
has issue date	2009-05-31(xsd:dateTime)
bibo:doi	10.1016/j.humpath.2008.08.015
bibo:pmid	19121843
has license	els-covid
sha1sum (hex)	fb856b1a30a090bac1268d3b87f263aaf976638b
schema:url	https://doi.org/10.1016/j.humpath.2008.08.015
resource representing a document's title	Systemic infection of avian influenza A virus H5N1 subtype in humans
has PubMed Central identifier	PMC7112124
has PubMed identifier	19121843
schema:publication	Human Pathology
resource representing a document's body	covid:fb856b1a30a090bac1268d3b87f263aaf976638b#body_text
is schema:about of	named entity 'AVIAN INFLUENZA A VIRUS' named entity 'intestinal epithelial cells' named entity 'confirmed' named entity 'diffuse alveolar damage' named entity 'lung' named entity 'hematopoietic' named entity 'nucleoprotein' named entity 'PATIENT' covid:arg/fb856b1a30a090bac1268d3b87f263aaf976638b named entity 'PATHOLOGY' named entity 'LARGE INTESTINAL' named entity 'BEYOND' named entity 'CONFIRMED BY' named entity 'MARKED' named entity 'PATHOLOGICAL' named entity 'NEEDED' named entity 'ZOONOTIC DISEASE' named entity 'ORGANS' named entity 'SYSTEMIC INFECTION' named entity 'NUCLEOPROTEIN' named entity 'RESULTS' named entity 'HUMANS' named entity 'DIFFUSE ALVEOLAR DAMAGE' named entity 'UPPER RESPIRATORY TRACT' named entity 'H5N1' named entity 'DISSEMINATION' named entity 'NEURONS' named entity 'LYMPHOID DEPLETION' named entity 'GLIAL CELLS' named entity 'SPECIFIC' named entity 'LUNG' named entity 'REACTIVE HEMOPHAGOCYTIC SYNDROME' named entity 'INFECTION' named entity 'AVIAN INFLUENZA A' named entity 'VIRAL REPLICATION' named entity 'MULTIPLE' named entity 'POSTMORTEM' named entity 'EPITHELIAL CELLS' named entity 'LYMPHOCYTES' named entity 'H5N1 VIRUS' named entity 'THE BRAIN' named entity 'VIRAL' named entity 'CULTURE' named entity 'VIRAL ANTIGEN' named entity 'ANTIGEN' named entity 'DETECTED' named entity 'HIGHLY' named entity 'CELLS' named entity 'CONFIRMED' named entity 'HEMATOPOIETIC' named entity 'SUBTYPE' named entity 'DISSEMINATED' named entity 'CHANGES' named entity 'NOTED' named entity 'BONE MARROW' named entity 'SMALL' named entity 'PATHOGENESIS' named entity 'STUDIES' named entity 'INFLUENZA A VIRUS H5N1 SUBTYPE' named entity 'FATAL' named entity 'RESPIRATORY SYSTEM' named entity 'PRODUCTIVE' named entity 'LOCALIZATION' named entity 'infection' named entity 'specific' named entity 'The' named entity 'large' named entity 'hematopoietic cells' named entity 'postmortem' named entity 'DAD' named entity 'exudate' named entity 'spleen' named entity 'tissue injury' named entity 'Immunohistochemistry'

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