About: Viral Life Cycles Captured in Three-Dimensions with Electron Microscopy Tomography

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Viral Life Cycles Captured in Three-Dimensions with Electron Microscopy Tomography
Creator	Kuhn, Richard Agbandje-Mckenna, Mavis Fu, Chi-Yu Johnson, Johnson
Source	Elsevier; Medline; PMC
abstract	Viruses hijack host cell functions and optimize them for viral replication causing a severe threat to human health. However, viruses are also tools to understand cell biology and they may be effective reagents in nano-medicine. Studies from the molecular to cellular levels are aimed at understanding the details of viral life cycles and the underlying virus-host interactions. Recent developments in electron microscopy tomography allow viral and cellular events to be observed in fine structural detail in three-dimension. By combining high-resolution structures of individual proteins and macro-complexes obtained by crystallography and electron cryo-microscopy and image reconstruction with reconstructions performed on sub-tomographic volumes, electron tomography has advanced the structural and mechanistic understanding of virus infections both in vitro and in host cells.
has issue date	2011-08-01(xsd:dateTime)
bibo:doi	10.1016/j.coviro.2011.06.008
bibo:pmid	21887207
has license	green-oa
sha1sum (hex)	fb7d22dbd056b414d86590eec14e213dbe8b1fbf
schema:url	https://doi.org/10.1016/j.coviro.2011.06.008
resource representing a document's title	Viral Life Cycles Captured in Three-Dimensions with Electron Microscopy Tomography
has PubMed Central identifier	PMC3163493
has PubMed identifier	21887207
schema:publication	Current Opinion in Virology
resource representing a document's body	covid:fb7d22dbd056b414d86590eec14e213dbe8b1fbf#body_text
is schema:about of	named entity 'life cycles' named entity 'ELECTRON MICROSCOPY TOMOGRAPHY' named entity 'REVIEW' named entity 'VOLUMES' named entity 'VIRAL AND' named entity 'FUNCTION' named entity 'LIFE CYCLES' named entity 'ALLOW' named entity 'UNDERSTANDING' named entity 'IMAGE RECONSTRUCTION' named entity 'VIRUS' named entity 'REAGENTS' named entity 'COMES' named entity 'CELL FUNCTIONS' named entity 'INFECTIONS' named entity 'NANOMEDICINE' named entity 'LEVELS' named entity 'CAUSING' named entity 'RECONSTRUCTIONS' named entity 'CELLULAR' named entity 'MOLECULAR' named entity 'HOST' named entity 'LIFE CYCLES' named entity 'ELECTRON TOMOGRAPHY' named entity 'STRUCTURAL' named entity 'COMBINING' named entity 'THREAT' named entity 'EFFECTIVE' named entity 'STRUCTURES' named entity 'VIRAL' named entity 'RECENT' named entity 'VIRAL' named entity 'INTERACTIONS' named entity 'CELL BIOLOGY' named entity 'OBTAINED BY' named entity 'DIMENSIONS' named entity 'EDITED' named entity 'VIRUS' named entity 'MAY BE' named entity 'VIRUSES' named entity 'HUMAN HEALTH' named entity 'STRUCTURE' named entity 'ISSUE' named entity 'UNDERSTAND' named entity 'STUDIES' named entity 'CRYSTALLOGRAPHY' named entity 'ELECTRON MICROSCOPY TOMOGRAPHY' named entity 'EVENTS' named entity 'OPTIMIZE' named entity 'PROTEINS' named entity 'IN VITRO' named entity 'PERFORMED' named entity 'VIRAL REPLICATION' named entity 'SEVERE' named entity 'ELECTRON CRYOMICROSCOPY' named entity 'TO BE OBSERVED' named entity 'INDIVIDUAL' named entity 'DIMENSIONS' named entity 'FINE' named entity 'DEVELOPMENTS' named entity 'ADVANCED' named entity 'UNDERLYING' named entity 'TOOLS' named entity 'HOST CELLS' named entity 'DETAILS' named entity 'electron microscopy' named entity 'tools' named entity 'proteins' named entity 'structural' named entity 'viral replication' named entity 'volumes' named entity 'infections' named entity 'Viruses' named entity 'Edited' named entity 'electron microscopy' named entity 'nanomedicine' named entity 'electron cryomicroscopy' named entity 'Viral'

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