About: CD13/aminopeptidase N in collagen vascular diseases

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About: CD13/aminopeptidase N in collagen vascular diseases Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	CD13/aminopeptidase N in collagen vascular diseases
Creator	Sone, Saburo Ae, Tamiya Ae, Tani Ae, Yanagawa Biraa, Ae Biraa, Yanjmaa Dan, H Dan, Hirohumi Hase, Ae Hase, Kayoko Hiroaki, A Hiroyuki, A Huang, Ae Huang, Luping Kenji, A Shimizu, Ae Shimizu, Teruki Sone, Ae Tamiya, H Tani, Ae Yanagawa, H
Source	Medline; PMC
abstract	To determine the significance of CD13/aminopeptidase N in collagen vascular diseases (CVD), we examined its activity and expression in sera and disease sites of patients with CVD. Significantly higher aminopeptidase activity was detected in bronchoalveolar lavage fluid from patients with interstitial lung diseases due to rheumatoid arthritis (RA), polymyositis/dermatomyositis (PM/DM), systemic sclerosis (SSc), and Sjögren's syndrome than from control subjects. Increased aminopeptidase activity and increased expression of CD13/aminopeptidase N protein were found in alveolar macrophages from CVD patients with interstitial lung diseases. Significantly higher aminopeptidase activity was detected in pleural effusions from patients with systemic lupus erythematosus (SLE) than in transudate effusions. The mean aminopeptidase activity in synovial fluids from RA patients was significantly higher than from patients with osteoarthritis. The mean value of serum aminopeptidase activity was significantly higher in patients with SLE, RA, SSc, and PM/DM than in normal subjects. This study suggests that the activity of CD13/aminopeptidase N, locally produced in the disease site, is a useful marker for CVD and that CD13/aminopeptidase N may have an important role in the pathogenesis of CVD.
has issue date	2003-09-12(xsd:dateTime)
bibo:doi	10.1007/s00296-003-0292-5
bibo:pmid	13680152
has license	no-cc
sha1sum (hex)	fb735a029adbbc14a849e57d7e08cae059714044
schema:url	https://doi.org/10.1007/s00296-003-0292-5
resource representing a document's title	CD13/aminopeptidase N in collagen vascular diseases
has PubMed Central identifier	PMC7079914
has PubMed identifier	13680152
schema:publication	Rheumatol Int
resource representing a document's body	covid:fb735a029adbbc14a849e57d7e08cae059714044#body_text
is schema:about of	named entity 'fluids' named entity 'aminopeptidase' named entity 'transudate' named entity 'activity' named entity 'activity' named entity 'expression' named entity 'aminopeptidase' named entity 'DUE TO' named entity 'CD13' named entity 'MEAN' named entity 'SERUM' named entity 'ALVEOLAR MACROPHAGES' named entity 'INTERSTITIAL LUNG DISEASES' named entity 'DETECTED' named entity 'PROTEIN ' named entity 'AMINOPEPTIDASE ACTIVITY' named entity 'ACTIVITY' named entity 'ROLE' named entity 'FOUND' covid:arg/fb735a029adbbc14a849e57d7e08cae059714044 named entity 'MEAN VALUE' named entity 'SIGNIFICANCE' named entity 'INCREASED' named entity 'LOCALLY' named entity 'MAY HAVE' named entity '28PM' named entity 'ITS' named entity 'PATHOGENESIS' named entity 'IS A' named entity 'PLEURAL EFFUSIONS' named entity 'SYNDROME' named entity 'N PROTEIN' named entity 'AMINOPEPTIDASE N' named entity 'SUBJECTS' named entity 'SLE' named entity 'COLLAGEN VASCULAR DISEASES' named entity 'EXAMINED' named entity 'STUDY' named entity 'IMPORTANT' named entity 'POLYMYOSITIS' named entity 'CD13' named entity 'DETERMINE' named entity 'EFFUSIONS' named entity 'PATIENTS' named entity 'SITES' named entity '27S' named entity 'SSC' named entity 'SYSTEMIC SCLEROSIS' named entity 'USEFUL' named entity 'MARKER' named entity 'HIGHER' named entity 'RHEUMATOID ARTHRITIS' named entity 'SYSTEMIC LUPUS ERYTHEMATOSUS' named entity 'INCREASED EXPRESSION' named entity 'NORMAL' named entity 'TRANSUDATE' named entity 'CVD' named entity 'SYNOVIAL FLUIDS' named entity 'SERA' named entity 'OSTEOARTHRITIS' named entity 'DISEASE'

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