About: The Lepidopteran endoribonuclease-U domain protein P102 displays dramatically reduced enzymatic activity and forms functional amyloids

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About: The Lepidopteran endoribonuclease-U domain protein P102 displays dramatically reduced enzymatic activity and forms functional amyloids Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Lepidopteran endoribonuclease-U domain protein P102 displays dramatically reduced enzymatic activity and forms functional amyloids
Creator	Monné, Magnus Tettamanti, Gianluca Falabella, Patrizia Grimaldi, Annalisa Laurino, Simona Pascale, Mariarosa Riviello, Lea Vogel, Heiko
Source	Elsevier; Medline; PMC
abstract	Abstract Hemocytes of Heliothis virescens (F.) (Lepidoptera, Noctuidae) larvae produce a protein, P102, with a putative endoribonuclease-U domain. In previous works we have shown that P102 is involved in Lepidopteran immune response by forming amyloid fibrils, which catalyze and localize melanin deposition around non-self intruders during encapsulation, preventing harmful systemic spreading. Here we demonstrate that P102 belongs to a new class of proteins that, at least in Lepidoptera, has a diminished endoribonuclease-U activity probably due to the lack of two out of five catalytically essential residues. We show that the P102 homolog from Trichoplusia ni (Lepidoptera, Noctuidae) displays catalytic site residues identical to P102, a residual endoribonuclease-U activity and the ability to form functional amyloids. On the basis of these results as well as sequence and structural analyses, we hypothesize that all the Lepidoptera endoribonuclease-U orthologs with catalytic site residues identical to P102 form a subfamily with similar function.
has issue date	2014-11-30(xsd:dateTime)
bibo:doi	10.1016/j.dci.2014.07.009
bibo:pmid	25043263
has license	els-covid
sha1sum (hex)	fb2f8737494208036cf0da180b5a8dfe6b19a192
schema:url	https://doi.org/10.1016/j.dci.2014.07.009
resource representing a document's title	The Lepidopteran endoribonuclease-U domain protein P102 displays dramatically reduced enzymatic activity and forms functional amyloids
has PubMed Central identifier	PMC7124382
has PubMed identifier	25043263
schema:publication	Developmental & Comparative Immunology
resource representing a document's body	covid:fb2f8737494208036cf0da180b5a8dfe6b19a192#body_text
is schema:about of	named entity 'REDUCED' named entity 'Heliothis virescens' named entity 'Lepidoptera' named entity 'functional' named entity 'ENZYMATIC ACTIVITY' named entity 'FORMS' named entity 'PROTEIN ' named entity 'IMMUNE RESPONSE' named entity 'PRODUCE' named entity 'A PROTEIN' named entity 'AMYLOIDS' named entity 'HELIOTHIS VIRESCENS' named entity 'DOMAIN' named entity 'RESIDUAL' named entity 'NOCTUIDAE' named entity 'CLASS' named entity 'ESSENTIAL' named entity 'SUBFAMILY' named entity 'PREVENTING' named entity 'FUNCTIONAL' named entity 'AMYLOIDS' named entity 'HEMOCYTES' named entity 'AMYLOID FIBRILS' named entity 'ENDORIBONUCLEASE' named entity 'WORKS' named entity 'SEQUENCE' named entity 'P102' named entity 'DOMAIN' named entity 'ENDORIBONUCLEASE' named entity 'SPREADING' named entity 'BASIS' named entity 'LOCALIZE' named entity 'INVOLVED' named entity 'SYSTEMIC' named entity 'SIMILAR' named entity 'LARVAE' named entity 'CATALYTIC SITE' named entity 'FUNCTION' named entity 'DISPLAYS' named entity 'DIMINISHED' named entity 'PROTEINS' named entity 'STRUCTURAL' named entity 'FORM' named entity 'NEW' named entity 'DISPLAYS' named entity 'FUNCTIONAL' named entity 'LEPIDOPTERA' named entity 'FORMING' named entity 'LACK' named entity 'HOMOLOG' named entity 'TRICHOPLUSIA NI' named entity 'DUE TO' named entity 'ENCAPSULATION' named entity 'THESE' named entity 'MELANIN DEPOSITION' named entity 'HERE' named entity 'P102' named entity 'ACTIVITY' named entity 'PREVIOUS' named entity 'NON-SELF' named entity 'IDENTICAL' named entity 'HAVE' named entity 'RESULTS' named entity 'HARMFUL' named entity 'TO FORM' named entity 'PROBABLY' named entity 'replicase' named entity 'Lepidopteran' named entity 'maximum likelihood' named entity 'RNA' named entity 'Caffarelli' named entity 'amyloids' named entity 'CBS' named entity 'RNases'

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