About: Epidemiological and clinical characteristics of three family clusters of COVID-19 transmitted by latent patients in China

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About: Epidemiological and clinical characteristics of three family clusters of COVID-19 transmitted by latent patients in China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Epidemiological and clinical characteristics of three family clusters of COVID-19 transmitted by latent patients in China
Creator	Li, Jing Chen, Li Zhang, Xinxin Liang, Hong Yu, Xiaoqi Sun, Qingfeng Ding, Jiguang Sun, Gangqiang Ye, Enling Zhang, Binbin
source	Medline; PMC
abstract	From 21 January 2020 to 9 February 2020, three family clusters involving 31 patients with coronavirus disease 2019 were identified in Wenzhou, China. The epidemiological and clinical characteristics of the family cluster patients were analysed and compared with those of 43 contemporaneous sporadic cases. The three index cases transmitted the infection to 28 family members 2–10 days before illness onset. Overall, 28 of the 41 sporadic cases and three of 31 patients in the family clusters came back from Wuhan (65.12 vs. 9.68%, P< 0.001). In terms of epidemiological characters and clinical symptoms, no significant differences were observed between the family cluster and sporadic cases. However, the lymphocyte counts of sporadic cases were significantly lower than those of family cluster cases ((1.32 ± 0.55) × 10(9)/l vs. (1.63 ± 0.70) × 10(9)/l, P = 0.037), and the proportion of hypoalbuminaemia was higher in sporadic cases (18/43, 41.86%) than in the family clusters (6/31, 19.35%) (P < 0.05). Within the family cluster, the second- and third-generation cases had milder clinical manifestations, without severe conditions, compared with the index and first-generation cases, indicating that the virulence gradually decreased following passage through generations within the family clusters. Close surveillance, timely recognition and isolation of the suspected or latent patient is crucial in preventing family cluster infection.
has issue date	2020-07-06(xsd:dateTime)
bibo:doi	10.1017/s0950268820001491
bibo:pmid	32624076
has license	cc-by
sha1sum (hex)	fb2b0da5a3d427358b4a1e0af67c53c236bcafb9
schema:url	https://doi.org/10.1017/s0950268820001491
resource representing a document's title	Epidemiological and clinical characteristics of three family clusters of COVID-19 transmitted by latent patients in China
has PubMed Central identifier	PMC7360955
has PubMed identifier	32624076
schema:publication	Epidemiol Infect
resource representing a document's body	covid:fb2b0da5a3d427358b4a1e0af67c53c236bcafb9#body_text
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