About: Acute phase proteins as local biomarkers of respiratory infection in calves

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Acute phase proteins as local biomarkers of respiratory infection in calves
Creator	Prohl, Annette Reinhold, Petra Rhode, Heidrun Schroedl, Wieland
Source	Medline; PMC
abstract	BACKGROUND: Cumulating reports suggest that acute phase proteins (APPs) do not only play a role as systemic inflammatory mediators, but are also expressed in different tissues as local reaction to inflammatory stimuli. The present study aimed to evaluate presence and changes in luminal lung concentrations of the APPs haptoglobin (Hp), lipopolysaccharide binding protein (LBP), C-reactive protein (CRP), and lactoferrin (Lf) in calves with an acute respiratory disease experimentally induced by Chlamydia (C.) psittaci. RESULTS: Intra-bronchial inoculation of the pathogen resulted in a consistent respiratory illness. In venous blood of the infected calves (n = 13), concentrations of plasma proteins and serum LBP were assessed (i) before exposure and (ii) 8 times within 14 days after inoculation (dpi). Increasing clinical illness correlated significantly with increasing LBP—and decreasing albumin concentrations in blood, both verifying a systemic acute phase response. Broncho-alveolar lavage fluid (BALF) was obtained from all 13 calves experimentally infected with C. psittaci at 4, 9 and 14 dpi, and from 6 uninfected healthy calves. Concentrations of bovine serum albumin (BSA), Hp, LBP, CRP and Lf in BALF were determined by ELISA. In infected animals, absolute concentrations of LBP and Hp in BALF correlated significantly with the respiratory score. The quotient [LBP]/[BSA] in BALF peaked significantly in acutely infected animals (4 dpi), showed a time-dependent decrease during the recovery phase (9-14 dpi), and was significantly higher compared to healthy controls. Concentrations of Hp and Lf in BALF as well as [Hp]/[BSA]—and [Lf]/[BSA]-quotients decreased during the study in infected animals, but were never higher than in healthy controls. CRP concentrations and [CRP]/[BSA]-quotient did not express significant differences between infected and healthy animals or during the course of infection. CONCLUSION: In conclusion, absolute concentrations of LBP in blood and BALF as well as the quotient [LBP]/[BSA] in BALF perfectly paralleled the clinical course of respiratory illness after infection. Beside LBP, the suitability of Hp and Lf as local biomarkers of respiratory infections in cattle and their role in the local response to pathogens is worth further investigation, while CRP does not seem to play a role in local defense mechanisms of the bovine lung.
has issue date	2015-07-25(xsd:dateTime)
bibo:doi	10.1186/s12917-015-0485-7
bibo:pmid	26209015
has license	cc-by
sha1sum (hex)	fb113c8235675412d874b092faf5b997ac410434
schema:url	https://doi.org/10.1186/s12917-015-0485-7
resource representing a document's title	Acute phase proteins as local biomarkers of respiratory infection in calves
has PubMed Central identifier	PMC4515006
has PubMed identifier	26209015
schema:publication	BMC Vet Res
resource representing a document's body	covid:fb113c8235675412d874b092faf5b997ac410434#body_text
is schema:about of	named entity 'RESPIRATORY INFECTION' named entity 'assessed' named entity 'calves' named entity 'CRP' named entity 'dpi' named entity 'acute phase proteins' named entity 'lactoferrin' named entity 'Results' named entity 'BSA' named entity 'BSA' named entity 'respiratory illness' named entity 'evaluate' named entity 'CRP' named entity 'C-reactive protein' named entity 'bovine serum albumin' named entity 'calves' named entity 'infection' named entity 'SYSTEMIC' named entity 'DETERMINED BY' named entity 'TIME' named entity 'LUNG' named entity 'LACTOFERRIN' named entity 'VENOUS BLOOD' named entity 'BIOMARKERS' named entity 'RESPONSE TO' named entity 'EVALUATE' named entity 'ACUTE RESPIRATORY DISEASE' named entity 'COMPARED' named entity 'CLINICAL COURSE' named entity 'BACKGROUND' named entity 'ACUTE PHASE PROTEINS' named entity 'PRESENT' named entity 'CHANGES' named entity 'PRESENCE' named entity 'HEALTHY' named entity 'STIMULI' named entity 'ROLE' named entity 'BIOMARKERS' named entity 'LOCAL' named entity 'CALVES' named entity 'BRONCHO-ALVEOLAR LAVAGE' named entity 'PROTEIN ' named entity 'BOVINE' named entity 'HIGHER' named entity 'INTRA' named entity 'LOCAL' named entity 'C-REACTIVE PROTEIN' named entity 'ACUTE PHASE RESPONSE' named entity 'NEVER' named entity 'BUT' named entity 'INFECTION' named entity 'PATHOGENS' named entity 'LBP' named entity 'RESPIRATORY ILLNESS' named entity 'HAPTOGLOBIN' named entity 'OBTAINED' named entity 'INFECTED' named entity 'CALVES' named entity 'QUOTIENT' named entity 'DECREASE' named entity 'ALBUMIN CONCENTRATIONS' named entity 'INOCULATION' named entity 'PLASMA PROTEINS' named entity 'EXPRESSED' named entity 'THEIR' named entity 'DEFENSE MECHANISMS' named entity 'RESPIRATORY INFECTIONS' named entity 'VERIFYING' named entity 'ANIMALS' named entity 'REPORTS' named entity 'TISSUES' named entity 'COURSE' named entity 'WORTH' named entity 'CLINICAL' named entity 'DID' named entity 'EXPOSURE' named entity 'CONCENTRATIONS' named entity 'CHLAMYDIA'

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