About: Inducing Brain Cooling Without Core Temperature Reduction in Pigs Using a Novel Nasopharyngeal Method: An Effectiveness and Safety Study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Inducing Brain Cooling Without Core Temperature Reduction in Pigs Using a Novel Nasopharyngeal Method: An Effectiveness and Safety Study
Creator	Bor-Seng-Shu, Edson Cavalcanti, Alexandre Silva, Eliezer Teixeira, Manoel Barreto, Miranda Barros, Ícaro De Lima Oliveira, Marcelo Einsfeld, Raphael Ferreira, Simões Lembo Conde De Paiva, Bernardo
Source	PMC
abstract	BACKGROUND: Acute brain lesions constitute an alarming public health concern. Neuroprotective therapies have been implemented to stabilize, prevent, or reduce brain lesions, thus improving neurological outcomes and survival rates. Hypothermia is the most effective approach, mainly attributed to the reduction in cellular metabolic activity. Whole-body cooling is currently implemented by healthcare professionals; however, adverse events are frequent, limiting the potential benefits of therapeutic hypothermia. Therefore, selective methods have been developed to reduce adverse events while delivering neuroprotection. Nasopharyngeal approaches are the safest and most effective methods currently considered. Our primary objective was to determine the effects of a novel nasopharyngeal catheter on the brain temperature of pigs. METHODS: In this prospective, non-randomized, interventional experimental trial, 10 crossbred pigs underwent nasopharyngeal cooling for 60 min followed by 15 min of rewarming. Nasopharyngeal catheters were inserted into the left nostril and properly positioned at the nasopharyngeal cavity. RESULTS: Nasopharyngeal cooling was associated with a decrease in brain temperature, which was more significant in the left cerebral hemisphere (p = 0.01). There was a reduction of 1.47 ± 0.86 °C in the first 5 min (p < 0.001), 2.45 ± 1.03 °C within 10 min (p < 0.001), and 4.45 ± 1.36 °C after 1 h (p < 0.001). The brain-core gradient was 4.57 ± 0.87 °C (p < 0.001). Rectal, esophageal, and pulmonary artery temperatures and brain and systemic hemodynamic parameters, remained stable during the procedure. Following brain cooling, values of oxygen partial pressure in brain tissue significantly decreased. No mucosal lesions were detected during nasal, pharyngeal, or oral inspection after nasopharyngeal catheter removal. CONCLUSIONS: In this study, a novel nasopharyngeal cooling catheter effectively induced and maintained exclusive brain cooling when combined with effective counter-warming methods. Exclusive brain cooling was safe with no device-related local or systemic complications and may be desired in selected patient populations.
has issue date	2019-07-17(xsd:dateTime)
bibo:doi	10.1007/s12028-019-00789-2
bibo:pmid	31317319
has license	no-cc
sha1sum (hex)	faee0c7e3b86ae504c4569c94c4b032969f33886
schema:url	https://doi.org/10.1007/s12028-019-00789-2
resource representing a document's title	Inducing Brain Cooling Without Core Temperature Reduction in Pigs Using a Novel Nasopharyngeal Method: An Effectiveness and Safety Study
has PubMed Central identifier	PMC7223440
has PubMed identifier	31317319
schema:publication	Neurocrit Care
resource representing a document's body	covid:faee0c7e3b86ae504c4569c94c4b032969f33886#body_text
is schema:about of	named entity 'reduce' named entity 'effective' named entity 'determine' named entity 'catheter' named entity 'Study' named entity 'Novel' named entity 'Effectiveness' named entity 'OUR' named entity 'PREVENT' named entity 'EFFECTS' named entity 'adverse events' named entity 'survival rates' named entity 'brain' named entity 'temperature' named entity 'Acute' named entity 'brain lesions' named entity 'Neuroprotective' named entity 'public health' named entity 'cellular metabolic activity' named entity 'nasopharyngeal catheter' named entity 'Our' named entity 'femoral artery' named entity 'brain tissue' named entity 'oral cavity' named entity 'brain lesions' named entity 'cerebrospinal fluid' named entity 'stroke' named entity 'nasopharyngeal' named entity 'nasopharyngeal' named entity 'physiological' named entity 'pre-hospital' named entity 'autoregulation' named entity 'upper airway' named entity 'lateral' named entity 'velocity' named entity 'USP' named entity 'therapeutic hypothermia' named entity 'Manaus' named entity 'catheters' named entity 'ketamine' named entity 'euthanized' named entity 'polynomial regression' named entity 'cardiovascular' named entity 'multi-frequency' named entity 'Minneapolis' named entity 'cellular metabolic activity' named entity '0.98' named entity 'neuroprotective' named entity 'fentanyl' named entity 'Research subjects' named entity 'vital signs' named entity 'average weight' named entity 'cortical surface' named entity 'short-term' named entity 'Experimental animals' named entity 'global ischemia' named entity 'local effects' named entity 'cardiac output' named entity 'oxygen' named entity 'FiO2' named entity 'hemodynamic' named entity 'Shapiro-Wilk test' named entity 'cortical parenchyma' named entity 'cardiac arrest' named entity 'experimental protocol' named entity 'oral cavity' named entity 'resuscitation' named entity 'Positive end-expiratory pressure' named entity 'ECG' named entity 'catheter' named entity 'mEq/L' named entity 'core temperature'

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