About: Outcome of hospitalisation for COVID-19 in patients with Interstitial Lung Disease: An international multicentre study.

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About: Outcome of hospitalisation for COVID-19 in patients with Interstitial Lung Disease: An international multicentre study. Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Outcome of hospitalisation for COVID-19 in patients with Interstitial Lung Disease: An international multicentre study.
Creator	Openshaw, Peter Ho, Ling-Pei Quint, Jennifer Molina-Molina, Maria Jones, Mark Kenneth Baillie, J Molyneaux, Philip Semple, Malcolm Chang, William Hart, Simon Henry, Michael Babu, Suresh Barratt, Shaney Docherty, Annemarie Drake, Thomas Forrest, Ian George, Peter Gibbons, Michael Harrison, Ewen Kreuter, Michael O'reilly, Katherine Poletti, Venerino Spencer, Lisa Stella, Giulia Thillai, Muhunthan Wells, Athol Jenkins, Gisli Chua, Felix Hutchinson, John Stone, Helen Adamali, Huzaifa Agnew, Sarah Barber, Christopher Bendstrup, Elisabeth Bianchi, Stephen Castillo Villegas, Diego Chaudhuri, Nazia Coker, Robina Crawshaw, Anjali Crowley, Louise Dosanjh, Davinder Fiddler, Christine Groom, Katherine Haney, Sarah Hearson, Glenn Heiden, Emily Howard, Lucy Hoyles, Rachel Hurley, Killian Jones, Steve Kokosi, Maria Mackay, Laura Mahendran, Siva Margaritopoulos, George O'brien, Aiden Packham, Alice Parfrey, Helen Porter, Joanna Renzoni, Elisabetta Rivera-Ortega, Pilar Russell, Anne-Marie Saini, Gauri Stewart, Iain Sturney, Sharon Thickett, David Wallis, Tim Ward, Katie West, Alex Wickremasinghe, Melissa Woodhead, Felix
Source	MedRxiv
abstract	Rationale: The impact of COVID-19 on patients with Interstitial Lung Disease (ILD) has not been established. Objectives: To assess outcomes following COVID-19 in patients with ILD versus those without in a contemporaneous age, sex and comorbidity matched population. Methods: An international multicentre audit of patients with a prior diagnosis of ILD admitted to hospital with COVID-19 between 1 March and 1 May 2020 was undertaken and compared with patients, without ILD obtained from the ISARIC 4C cohort, admitted with COVID-19 over the same period. The primary outcome was survival. Secondary analysis distinguished IPF from non-IPF ILD and used lung function to determine the greatest risks of death. Measurements and Main Results: Data from 349 patients with ILD across Europe were included, of whom 161 were admitted to hospital with laboratory or clinical evidence of COVID-19 and eligible for propensity-score matching. Overall mortality was 49% (79/161) in patients with ILD with COVID-19. After matching ILD patients with COVID-19 had higher mortality (HR 1.60, Confidence Intervals 1.17-2.18 p=0.003) compared with age, sex and co-morbidity matched controls without ILD. Patients with a Forced Vital Capacity (FVC) of <80% had an increased risk of death versus patients with FVC [≥]80% (HR 1.72, 1.05-2.83). Furthermore, obese patients with ILD had an elevated risk of death (HR 1.98, 1.13-3.46). Conclusions: Patients with ILD are at increased risk of death from COVID-19, particularly those with poor lung function and obesity. Stringent precautions should be taken to avoid COVID-19 in patients with ILD.
has issue date	2020-07-17(xsd:dateTime)
bibo:doi	10.1101/2020.07.15.20152967
has license	medrxiv
sha1sum (hex)	fac950e6715b0a14b17c977022ed1e5d2ef01489
schema:url	https://doi.org/10.1101/2020.07.15.20152967
resource representing a document's title	Outcome of hospitalisation for COVID-19 in patients with Interstitial Lung Disease: An international multicentre study.
resource representing a document's body	covid:fac950e6715b0a14b17c977022ed1e5d2ef01489#body_text
is schema:about of	named entity 'patients' named entity '245' named entity 'ABSTRACT' named entity 'COVID-19' named entity 'Interstitial' named entity 'COVID' named entity 'COVID' named entity 'Interstitial Lung Disease' named entity 'risk of death' named entity 'respiratory support' named entity 'risk factors' named entity 'SARS-CoV-2' named entity 'respiratory support' named entity 'COVID-19' named entity 'co-morbidity' named entity 'respiratory infection'

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