About: Avian Interferon-Inducible Transmembrane Protein Family Effectively Restricts Avian Tembusu Virus Infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Avian Interferon-Inducible Transmembrane Protein Family Effectively Restricts Avian Tembusu Virus Infection
Creator	Summerfield, Artur Chen, Ji-Long Chen, Shaoying Chen, Shilong Chi, Xiaojuan Wang, Song Tsurudome, Masato Yang, Zhou Chen, Jieying Na, Yang Shao, Wenhan Wang, Long Zeng, Xiancheng Zhang, Lanlan Antonio, Juarez Quaresma, Simões Goraya, Mohsan Mu, Goraya
Source	Medline; PMC
abstract	Avian Tembusu virus (ATMUV) is a highly pathogenic flavivirus that causes significant economic losses to the Chinese poultry industry. Our previous experiments demonstrated that ATMUV infection effectively triggered host innate immune response through MDA5 and TLR3-dependent signaling pathways. However, little information is available on the role of interferon-stimulated genes (ISGs) in defending against ATMUV infection. In this study, we found that ATMUV infection induced robust expression of type I and type III interferon (IFNs) in duck tissues. Furthermore, we observed that expression of interferon-inducible transmembrane proteins (IFITMs) was significantly upregulated in DEF and DF-1 cells after infection with ATMUV. Similar results were obtained from in vivo studies using ATMUV-infected ducklings. Importantly, we showed that knockdown of endogenous IFITM1 or IFITM3 by specific shRNA markedly enhanced ATMUV replication in DF-1 cells. However, disruption of IFITM2 expression had no obvious effect on the ATMUV replication. In addition, overexpression of chicken or duck IFITM1 and IFITM3 in DF-1 cells impaired the replication of ATMUV. Taken together, these results reveal that induced expression of avian IFITM1 and IFITM3 in response to ATMUV infection can effectively restrict the virus replication, and suggest that increasing IFITM proteins in host may be a useful strategy for control of ATMUV infection.
has issue date	2017-04-20(xsd:dateTime)
bibo:doi	10.3389/fmicb.2017.00672
bibo:pmid	28473814
has license	cc-by
sha1sum (hex)	fa5d4e0d5a2afc924b07e8835aa0ac3cf0646089
schema:url	https://doi.org/10.3389/fmicb.2017.00672
resource representing a document's title	Avian Interferon-Inducible Transmembrane Protein Family Effectively Restricts Avian Tembusu Virus Infection
has PubMed Central identifier	PMC5397487
has PubMed identifier	28473814
schema:publication	Front Microbiol
resource representing a document's body	covid:fa5d4e0d5a2afc924b07e8835aa0ac3cf0646089#body_text
is schema:about of	named entity 'INTERFERON' named entity 'RESTRICTS' named entity 'demonstrated' named entity 'endogenous' named entity 'infection' named entity 'effectively' named entity 'Virus' named entity 'TRANSMEMBRANE PROTEIN' named entity 'PROTEIN FAMILY' named entity 'INFORMATION' named entity 'PROTEINS' named entity 'IN VIVO STUDIES' named entity 'SHRNA' named entity 'INFECTION INDUCED' named entity 'ENDOGENOUS' named entity 'AVIAN' named entity 'PREVIOUS' named entity 'REVEAL' named entity 'EXPERIMENTS' named entity 'HIGHLY' named entity 'CELLS' named entity 'LITTLE' named entity 'DEPENDENT' named entity 'TLR3' named entity 'TYPE I' named entity 'INDUCED' named entity 'CHICKEN' named entity 'IFITM2' named entity 'OUR' named entity 'TISSUES' named entity 'STRATEGY' named entity 'IS A' named entity 'OBSERVED' named entity 'VIRUS REPLICATION' named entity 'USEFUL' named entity 'SPECIFIC' named entity 'EFFECT' named entity 'DEMONSTRATED' named entity 'EXPRESSION' named entity 'VIRUS INFECTION' named entity 'CAUSES' named entity 'CHINESE' named entity 'INFECTION' named entity 'IFITM3' named entity 'RESPONSE TO' named entity 'POULTRY INDUSTRY' named entity 'CONTROL' named entity 'TAKEN' named entity 'MAY BE A' named entity 'TRIGGERED' named entity 'RESULTS' named entity 'DUCK' named entity 'TRANSMEMBRANE PROTEINS' named entity 'DF-1' named entity 'UPREGULATED' named entity 'THESE' named entity 'IMPAIRED' named entity 'INTERFERON' named entity 'INNATE IMMUNE RESPONSE' named entity 'ROBUST' named entity 'TEMBUSU VIRUS' named entity 'OVEREXPRESSION' named entity 'HOST' named entity 'MARKEDLY'

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