About: Effect of Chloroquine, Hydroxychloroquine, and Azithromycin on the Corrected QT Interval in Patients With SARS-CoV-2 Infection

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About: Effect of Chloroquine, Hydroxychloroquine, and Azithromycin on the Corrected QT Interval in Patients With SARS-CoV-2 Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Effect of Chloroquine, Hydroxychloroquine, and Azithromycin on the Corrected QT Interval in Patients With SARS-CoV-2 Infection
Creator	Chang, David Kim, Soo Epstein, Laurence Saleh, Moussa Willner, Jonathan Mansoor, Amtul Mitra, Raman Gabriels, James Beldner, Stuart Beom, ; Chinitz, Jason Goldner, Bruce Ismail, Haisam John, Roy Mahmood, Eitezaz Makker, Parth Mountantonakis, Stavros Skipitaris, Nicholas
Source	Medline; PMC
abstract	The novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is responsible for the global coronavirus disease 2019 pandemic. Small studies have shown a potential benefit of chloroquine/hydroxychloroquine±azithromycin for the treatment of coronavirus disease 2019. Use of these medications alone, or in combination, can lead to a prolongation of the QT interval, possibly increasing the risk of Torsade de pointes and sudden cardiac death. METHODS: Hospitalized patients treated with chloroquine/hydroxychloroquine±azithromycin from March 1 to the 23 at 3 hospitals within the Northwell Health system were included in this prospective, observational study. Serial assessments of the QT interval were performed. The primary outcome was QT prolongation resulting in Torsade de pointes. Secondary outcomes included QT prolongation, the need to prematurely discontinue any of the medications due to QT prolongation, and arrhythmogenic death. RESULTS: Two hundred one patients were treated for coronavirus disease 2019 with chloroquine/hydroxychloroquine. Ten patients (5.0%) received chloroquine, 191 (95.0%) received hydroxychloroquine, and 119 (59.2%) also received azithromycin. The primary outcome of torsade de pointes was not observed in the entire population. Baseline corrected QT interval intervals did not differ between patients treated with chloroquine/hydroxychloroquine (monotherapy group) versus those treated with combination group (chloroquine/hydroxychloroquine and azithromycin; 440.6±24.9 versus 439.9±24.7 ms, P=0.834). The maximum corrected QT interval during treatment was significantly longer in the combination group versus the monotherapy group (470.4±45.0 ms versus 453.3±37.0 ms, P=0.004). Seven patients (3.5%) required discontinuation of these medications due to corrected QT interval prolongation. No arrhythmogenic deaths were reported. CONCLUSIONS: In the largest reported cohort of coronavirus disease 2019 patients to date treated with chloroquine/hydroxychloroquine±azithromycin, no instances of Torsade de pointes, or arrhythmogenic death were reported. Although use of these medications resulted in QT prolongation, clinicians seldomly needed to discontinue therapy. Further study of the need for QT interval monitoring is needed before final recommendations can be made. VISUAL OVERVIEW: A visual overview is available for this article.
has issue date	2020-04-29(xsd:dateTime)
bibo:doi	10.1161/circep.120.008662
bibo:pmid	32347743
has license	no-cc
sha1sum (hex)	f9faea63dc6770ff09a577c788f08e6904b21099
schema:url	https://doi.org/10.1161/circep.120.008662
resource representing a document's title	Effect of Chloroquine, Hydroxychloroquine, and Azithromycin on the Corrected QT Interval in Patients With SARS-CoV-2 Infection
has PubMed Central identifier	PMC7299095
has PubMed identifier	32347743
schema:publication	Circ Arrhythm Electrophysiol
resource representing a document's body	covid:f9faea63dc6770ff09a577c788f08e6904b21099#body_text
is schema:about of	named entity 'halofantrine' named entity 'bradycardia' named entity 'proarrhythmic' named entity 'case reports' named entity 'Northwell Health' named entity 'risk factors' named entity 'HCQ' named entity 'cardiac arrhythmias' named entity 'TdP' named entity 'combination therapy' named entity 'hydroxychloroquine' named entity 'cell fusion' named entity 'bundle branch block' named entity 'coronavirus disease 2019' named entity 'monotherapy' named entity 'QT interval' named entity 'COVID-19' named entity 'T-wave' named entity 'morphology' named entity 'hydroxychloroquine' named entity 'hydroxychloroquine' named entity 'telemetry' named entity 'QT prolongation' named entity 'gene' named entity 'hypersensitivity' named entity 'transmitted to humans' named entity 'virus-cell fusion' named entity 'QTc' named entity 'torsade de pointes' named entity 'prolonged QT interval' named entity 'combination therapy' named entity 'monomorphic ventricular tachycardia' named entity 'QT interval' named entity 'QT prolongation' named entity 'overdose' named entity 'June 2020' named entity 'cardiac electrophysiologist' named entity 'COVID-19 infections' named entity 'Northwell Health' named entity 'control population' named entity 'TdP' named entity 'heart disease' named entity 'TdP' named entity 'ECG' named entity 'Northwell' named entity 'ECGs' named entity 'lidocaine' named entity 'QTc' named entity 'QTc' named entity 'TdP' named entity 'observational studies' named entity 'corrected QT interval' named entity 'endosomal' named entity 'QTc' named entity 'azithromycin' named entity 'QTc' named entity 'QTc' named entity 'SARS-CoV' named entity 'chloroquine' named entity 'T-wave' named entity 'left bundle branch block' named entity 'ECG' named entity 'atrial fibrillation' named entity 'QT prolongation'

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